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Deciphering the Multifaceted Mechanisms of Antimicrobial Peptides

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1288

Special Issue Editor


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Guest Editor
Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Interests: antimicrobial peptides; mechanism of peptide drugs; bacterial resistance; antibiotic alternatives; IgY antobody; vaccines; drug development for the treatment bacterial infection
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Special Issue Information

Dear Colleagues,

Antimicrobial peptides (AMPs) are a diverse group of endogenous molecules that play a crucial role in the innate immune system of virtually all living organisms. They are nature's ancient defense against pathogens, including bacteria, viruses, fungi, and parasites. AMPs exhibit broad-spectrum antimicrobial activity and are considered a promising alternative to conventional antibiotics in the face of rising antibiotic resistance. This Special Issue aims to bring together cutting-edge research that delves into the complex mechanisms underlying the action of AMPs, shedding light on their potential in therapeutic applications and their evolutionary significance in the perpetual arms race between hosts and pathogens. AMPs are characterized by their cationic nature, amphipathic structure, and diverse mechanisms of action, which include membrane disruption, inhibition of cellular processes, and immune modulation.

In this Special Issue of IJMS, we invite authors to contribute original research and review articles focusing on elucidating the fundamental molecular and cellular mechanisms underlying the biology of AMPs.

Prof. Dr. Xiumin Wang
Guest Editor

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Keywords

  • antimicrobial peptides
  • antimicrobial activity
  • mechanisms of action
  • membrane disruption
  • inhibition of cellular processes
  • immune modulation

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Published Papers (1 paper)

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Research

15 pages, 1729 KB  
Article
Engineering Epitope-Specific IgY Antibodies to Neutralize the Major Fel d 1 Allergen in Cats
by Xinya Tian, Chunxiao Li, Wei An, Yifei Wang, Zhenlong Wang, Jiaxue Wang, Xiaoxin Fu, Bing Han, Hui Tao, Christopher Jon Andrews, Jinquan Wang and Xiumin Wang
Int. J. Mol. Sci. 2026, 27(5), 2500; https://doi.org/10.3390/ijms27052500 - 9 Mar 2026
Viewed by 708
Abstract
Approximately 10–24% of people suffer from a cat allergy. Fel d 1, the major allergen, triggers reactions in approximately 94% of sensitized individuals. Current therapeutic strategies for allergic diseases primarily involve medication or immunotherapy to alleviate symptoms, which are often burdened by low [...] Read more.
Approximately 10–24% of people suffer from a cat allergy. Fel d 1, the major allergen, triggers reactions in approximately 94% of sensitized individuals. Current therapeutic strategies for allergic diseases primarily involve medication or immunotherapy to alleviate symptoms, which are often burdened by low efficacy, high cost, and extended duration, posing significant challenges for patients. In contrast, IgY antibodies offer a promising alternative by reducing the level of allergens produced by cats. In this study, T-cell epitopes of Fel d 1 were predicted using ProPred/CTLpred, connected via a suitable linker (GGGGS), and expressed in E. coli. Immunization of mice and hens with recombinant cFel d 1 yielded high-titer specific antibodies (IgG: 1:301,500; IgY: 1:4,194,304). Cats administered anti-cFel d 1 IgY-enriched yolk powder (1–3% of diet) for four weeks exhibited a 30–71% reduction in salivary Fel d 1. These findings indicate that the allergen epitope-targeted IgY strategy effectively reduces allergen levels in cats, providing a promising basis for preventing and treating allergic conditions. Full article
(This article belongs to the Special Issue Deciphering the Multifaceted Mechanisms of Antimicrobial Peptides)
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