The Importance of Inflammation as a Link Between Adipokines and Myokines in Obesity

Dear Colleagues,

Obesity triggers inflammation, disrupting adipokine and myokine signaling, which affects metabolic balance, impairs adipose tissue differentiation, and reduces mitochondrial function in both skeletal muscle and adipose tissue. In BMI-discordant twin studies, obese twins showed mitochondrial downregulation and elevated inflammatory markers, particularly in adipose tissue, and had a higher risk of fatty liver and insulin resistance. Sarcopenic obesity, characterized by muscle loss and fat gain, increases cardiometabolic risk, especially in older adults, as pro-inflammatory adipokines like TNFα and IL-6 inhibit muscle regeneration. Myosteatosis worsens muscle function, impairing muscle contractility and metabolism through lipotoxicity and insulin resistance. Understanding adipose–muscle crosstalk and its systemic impact is essential.

This Special Issue is supervised by Prof. Dr. Maria Greabu and assisted by our Topical Advisory Panel Member Dr. Bogdana Virgolici (University of Medicine and Pharmacy).

Prof. Dr. Maria Greabu
Guest Editor

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