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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1005 | Submission Open
Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Precision Cancer Medicine: Molecular Insights, Biological Events and Clinical Perspectives submission deadline 20 Jun 2026 | Viewed by 760 | Submission Open
Keywords: multi-omics at bulk level; single-cell multi-omics; precision oncology; precision immune-oncology; tumor molecular profiling
(This special issue belongs to the Section Molecular Oncology)
Natural Antioxidants—Sources, Characteristics, and Biological Activity
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 730 | Submission Open
Keywords: natural antioxidants; oxidative stress; reactive oxygen species; inflammation; free radicals; structure– activity relationship; nutraceuticals; synergistic effects; plant-derived compounds; drug discovery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases submission deadline 20 Jun 2026 | 1 articles | Viewed by 716 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer diagnostics; non-invasive tests; liquid biopsy; cancer therapy; biomarker discovery; nanotechnology; EV engineering; drug delivery; neurodegenerative diseases; cardiovascular diseases; infectious diseases; autoimmune diseases; precision diagnostics
(This special issue belongs to the Section Molecular Oncology)
Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 652 | Submission Open
Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations; “ Omics”   ; spatial biology of 3D
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Leukemia: Molecular Immune Mechanisms submission deadline 20 Jun 2026 | Viewed by 562 | Submission Open
Keywords: leukemia; immune system; Genetic Mutations and Alterations; Immune Evasion Mechanisms; Immune Cell Dysfunction; Cytokine Networks; Bone Marrow Microenvironment; immunotherapy strategies
(This special issue belongs to the Section Molecular Immunology)
Molecular Research on Actinomycetes-Derived Natural Products
edited by Fong Tian Wong
submission deadline 20 Jun 2026 | Viewed by 536 | Submission Open
Keywords: actinomycetes; natural products; actinobacterial; genome mining; omics; secondary metabolites; genetic engineering; discovery; structural diversity
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition
edited by Marzena Helena Olesińska and Magdalena Szmyrka
submission deadline 20 Jun 2026 | Viewed by 392 | Submission Open
Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases
(This special issue belongs to the Section Molecular Immunology)
Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges
edited by
submission deadline 20 Jun 2026 | Viewed by 346 | Submission Open
Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Pathophysiology of Placenta Accreta Spectrum
edited by Jessian L. Munoz
submission deadline 20 Jun 2026 | Viewed by 325 | Submission Open
Keywords: placenta accreta; invasive placenta; trophoblasts; placenta; high-risk pregnancy; placenta previa; in vitro fertilization; biomarkers; multi-omics research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds in Cancers: Second Edition submission deadline 20 Jun 2026 | Viewed by 312 | Submission Open
Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Telomeres in Development, Senescence and Genome Instability: 2nd Edition
edited by Michal Zalzman
submission deadline 20 Jun 2026 | Viewed by 303 | Submission Open
Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence
(This special issue belongs to the Section Molecular Genetics and Genomics)
Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management
edited by Alessio Bruni
submission deadline 20 Jun 2026 | Viewed by 299 | Submission Open
Keywords: urothelial cancer; bladder cancer; radiation therapy; trimodality approach; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Structural and Functional Insights into Chemokines and Chemokine Receptors in Immune Pathologies
edited by
submission deadline 20 Jun 2026 | Viewed by 270 | Submission Open
Keywords: chemokines; chemokine receptors; immune pathologies; signaling mechanisms; therapeutic targeting
(This special issue belongs to the Section Molecular Immunology)
The Chitosan Biomaterials: Advances and Challenges, 3rd Edition
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 20 Jun 2026 | Viewed by 227 | Submission Open
Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials
(This special issue belongs to the Section Materials Science)
Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment
edited by Madan Mohan Kwatra
submission deadline 20 Jun 2026 | Viewed by 224 | Submission Open
Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering
edited by
submission deadline 20 Jun 2026 | Viewed by 219 | Submission Open
Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility
(This special issue belongs to the Section Materials Science)
Sustainable Material Development Through Waste Utilization: From Molecular Insights to Functional Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 202 | Submission Open
Keywords: sustainable materials; waste-derived materials; biodegradable polymers; green chemistry; functionalization; structure– property relationships; chemical modification; recycling; valorization; circular economy; composites; analytical techniques; industrial waste; agricultural waste
(This special issue belongs to the Section Materials Science)
Genomics and Epigenetics of Stem Cell: An Update
edited by
submission deadline 20 Jun 2026 | Viewed by 201 | Submission Open
Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Interplay Between Aging, Dementia and Renal Function: Mechanisms, Biomarkers and Therapeutic Targets
edited by
submission deadline 20 Jun 2026 | Viewed by 200 | Submission Open
Keywords: aging; dementia; neuroinflammation; kidney– brain axis; translational research; biomarkers; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside
edited by Antonio Arnaiz-Villena
submission deadline 20 Jun 2026 | Viewed by 197 | Submission Open
Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV
(This special issue belongs to the Section Molecular Immunology)
Graphene-based Nanocomposites
edited by
submission deadline 20 Jun 2026 | Viewed by 195 | Submission Open
Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Horizons in Pain Therapeutics
edited by Alaa Abd-Elsayed
submission deadline 20 Jun 2026 | Viewed by 194 | Submission Open
Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling Bioactive Peptides: Structure, Function, and Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 187 | Submission Open
Keywords: bioactive peptides; peptide structure– activity relationship; peptidomics; bioactivity assays; human health
(This special issue belongs to the Section Macromolecules)
Natural Bioactive Compounds for Human Health, 3rd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 179 | Submission Open
Keywords: natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Parasitic Diseases
edited by Rajendranath Ramasawmy
submission deadline 20 Jun 2026 | Viewed by 176 | Submission Open
Keywords: parasites; molecular mechanisms; pathogenesis; genetics; symptomatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Endometriosis: Current Trends and Research Developments submission deadline 20 Jun 2026 | Viewed by 176 | Submission Open
Keywords: endometriosis; molecular mechanisms; pathophysiology; hormonal regulation; immune response; epigenetics; inflammation; biomarkers; transcriptomics; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Infectious Diseases and Infection Models in Laboratory Animals
edited by and Fumio Ike
submission deadline 20 Jun 2026 | Viewed by 175 | Submission Open
Keywords: infection model; Infectious diseases in laboratory animals; bacterial infection; viral infection; parasitic infection; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Informatics and AI in Cancer Research
edited by and
submission deadline 20 Jun 2026 | Viewed by 174 | Submission Open
Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data
(This special issue belongs to the Section Molecular Informatics)
Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement
edited by
submission deadline 20 Jun 2026 | Viewed by 171 | Submission Open
Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Modeling in Pharmaceutical Sciences
edited by
submission deadline 20 Jun 2026 | Viewed by 171 | Submission Open
Keywords: molecular modeling; computer-aided drug design; molecular docking; drug discovery; quantum chemistry; molecular dynamics simulations; virtual screening; computational pharmacology; pharmacy; in silico methods
(This special issue belongs to the Section Molecular Pharmacology)
Precision Medicine for Cancer-Associated Thrombosis: The Role of Biomarkers
edited by Darko Antic
submission deadline 20 Jun 2026 | Viewed by 165 | Submission Open
Keywords: biomarkers; precision medicine; cancer-associated thrombosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Antioxidant Activity
edited by Agnieszka Filipek
submission deadline 20 Jun 2026 | Viewed by 164 | Submission Open
Keywords: antioxidants; advanced mechanisms of action; signaling pathways; molecular mechanism; biologically active compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cellular Memory in Response to Environmental Conditions
edited by
submission deadline 20 Jun 2026 | Viewed by 160 | Submission Open
Keywords: cellular memory; cellular environment; embryonic development; epigenetics; transgenerational inheritance; mammals; DOHaD
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Biotic and Abiotic Stress Responses in Trees
edited by
submission deadline 20 Jun 2026 | Viewed by 155 | Submission Open
Keywords: drought stress; nutrient deficiency; salinity stress; pathogen defense; transcriptional regulation; epigenetic modifications; signal transduction; bioinformatics & multi-omics analysis; breeding for stress resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Mechanobiology of Regeneration
edited by and Timothy R. Deer
submission deadline 20 Jun 2026 | Viewed by 149 | Submission Open
Keywords: mechanotransduction; regeneration; stem cells; extracellular matrix; tissue repair
(This special issue belongs to the Section Molecular Biophysics)
New Perspectives in Protein Structure
edited by
submission deadline 20 Jun 2026 | Viewed by 142 | Submission Open
Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins
(This special issue belongs to the Section Molecular Biophysics)
Recent Advances in Computer-Aided Drug Design
edited by
submission deadline 20 Jun 2026 | Viewed by 127 | Submission Open
Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning
(This special issue belongs to the Section Molecular Pharmacology)
Gene Regulation in Endocrine Disease, 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 125 | Submission Open
Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Machine Learning Approaches in Drug Molecule Design
edited by
submission deadline 20 Jun 2026 | Viewed by 123 | Submission Open
Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery
(This special issue belongs to the Section Molecular Informatics)
Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease
edited by Alessandra Porcu
submission deadline 20 Jun 2026 | Viewed by 113 | Submission Open
Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit
(This special issue belongs to the Section Molecular Neurobiology)
Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity
edited by Bourlaye Fofana and
submission deadline 20 Jun 2026 | Viewed by 75 | Submission Open
Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity
(This special issue belongs to the Section Molecular Plant Sciences)
New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition
edited by
submission deadline 20 Jun 2026 | Submission Open
Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling
(This special issue belongs to the Section Molecular Immunology)
The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition
edited by
submission deadline 20 Jun 2026 | Submission Open
Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents
(This special issue belongs to the Section Molecular Microbiology)
Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease submission deadline 20 Jun 2026 | Submission Open
Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Pregnancy-Related Complications
edited by Kallirhoe Kalinderi
submission deadline 25 Jun 2026 | Viewed by 202 | Submission Open
Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)
edited by
submission deadline 25 Jun 2026 | Viewed by 75 | Submission Open
Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Functions and Applications of Natural Products: 2nd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 66 | Submission Open
Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mitochondrial Function in Human Health and Disease: 3rd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 64 | Submission Open
Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT
(This special issue belongs to the Section Biochemistry)
Molecular Progression of Gut Microbiota—2nd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 55 | Submission Open
Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis
(This special issue belongs to the Section Molecular Microbiology)
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