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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Concepts on the Mechanisms of Inflammation, Autoimmunity and Tumorigenesis

edited by

Marina Arleevskaya

and Yves Renaudineau

submission deadline 30 Dec 2026 | Viewed by 225 | Submission Open

Keywords: autoimmunity; immunology; inflammation; tumorigenesis; lipid metabolism; rheumatology

(This special issue belongs to the Section Molecular Immunology)

Natural Bioactive Compounds as Modulators of Oxidative Stress and Inflammation

edited by

Ignazio Barbagallo

submission deadline 30 Dec 2026 | Viewed by 220 | Submission Open

Keywords: natural compounds; redox homeostasis; inflammatory signaling; nutraceuticals; antioxidant response; sports nutrition

(This special issue belongs to the Section Biochemistry)

Plant Responses to Biotic and Abiotic Stresses—Second Edition

edited by

Shu Yuan

submission deadline 30 Dec 2026 | Viewed by 212 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; acclimation and tolerance; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in the Pathology and Pathogenetic Mechanisms of Diabetic Neuropathy

edited by

Aditya K. Singh

submission deadline 30 Dec 2026 | Viewed by 210 | Submission Open

Keywords: diabetic; neuroinflammation; neurovascular pathology; neuropathy; nerve injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

AI-Driven Molecular Modeling and Simulation in Biomedical Research and Biophysics

edited by

Whelton Miller

submission deadline 30 Dec 2026 | Viewed by 170 | Submission Open

Keywords: artificial intelligence (AI); machine learning (ML); biophysics; computational biology; molecular docking; molecular dynamics (MD); quantum mechanics; structure–activity relationships; computer-aided drug design (CADD); homology modeling

(This special issue belongs to the Section Molecular Informatics)

New Molecular Research on Antimicrobial Resistance

edited by

Anastasia Spiliopoulou

submission deadline 30 Dec 2026 | Viewed by 155 | Submission Open

Keywords: antimicrobial resistance; carbapenem-resistant enterobacterales; carbapenemases; multidrug-resistant organisms (MDROs); antifungal resistance; vancomycin-resistant Enterococcus (VRE); methicillin-resistant Staphylococcus aureus (MRSA); colonization by multidrug-resistant pathogens; healthcare-associated infections

(This special issue belongs to the Section Molecular Microbiology)

Natural Products and Derivatives: Isolation, Characterization, and Biological Activities

edited by

Cristian Paz

submission deadline 30 Dec 2026 | Viewed by 138 | Submission Open

Keywords: natural products; bioactive compounds; structure elucidation; biotransformation; semisynthesis; chemical modification; medicinal chemistry; molecular docking; molecular dynamics; artificial intelligence; drug discovery; enzyme inhibitors; protein modulators; antimicrobial agents; anticancer agents; neuroprotective compounds; pharmacological evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Genetic Regulation, Omics Innovation and Precision Breeding in Crops

edited by

Shaozhen He

and Xu Li

submission deadline 30 Dec 2026 | Viewed by 120 | Submission Open

Keywords: crop molecular breeding; omics analysis; biotic and abiotic stress tolerance; gene function; transcriptional regulation; protein–protein interactions; germplasm innovation; genetic regulatory mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Biology of Human Melanocytes and Pigmentation

edited by Tai Kyung Noh

submission deadline 30 Dec 2026 | Viewed by 105 | Submission Open

Keywords: melanogenesis; pigmentary disorders; hyperpigmentation; molecular signaling pathways; dermatological therapeutics; skin microenvironment; laser–tissue interaction; skin-brightening agents; melasma; photobiology

(This special issue belongs to the Section Molecular Biology)

Advances in Cell Metabolism in Endocrine Diseases, 2nd Edition

edited by

Antonella Muscella

submission deadline 30 Dec 2026 | Viewed by 104 | Submission Open

Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Next-Gen Cell Immunotherapies: From CAR-T to Synthetic Platforms

edited by Claudio Mussolino

submission deadline 30 Dec 2026 | Viewed by 93 | Submission Open

Keywords: cell-based immunotherapy; CAR-T cells; genome engineering; epigenetic engineering; synthetic biology; CRISPR; immune cell engineering; CAR-NK cells; T cell exhaustion; multiplex editing

(This special issue belongs to the Section Molecular Immunology)

Food and Plants Nanotechnology: Challenges and Future Prospects

edited by Luís R. Silva

submission deadline 30 Dec 2026 | Viewed by 73 | Submission Open

Keywords: nanotechnology; food safety; smart nanocarriers; nanosensors; antimicrobial nanomaterials; nano-enabled delivery systems

(This special issue belongs to the Section Molecular Nanoscience)

Galectins (Gals), 2nd Edition

edited by

Luciano Pirone

submission deadline 31 Dec 2026 | 12 articles | Viewed by 26019 | Submission Open

Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 31 Dec 2026 | 15 articles | Viewed by 19667 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 31 Dec 2026 | 4 articles | Viewed by 19021 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 15396 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms

edited by

Masashi Tanaka

submission deadline 31 Dec 2026 | 4 articles | Viewed by 14048 | Submission Open

Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation

(This special issue belongs to the Section Molecular Neurobiology)

Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 31 Dec 2026 | 7 articles | Viewed by 11954 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2026 | 5 articles | Viewed by 10128 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends in Redox Physiology Research

edited by Fotios Tekos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 9074 | Submission Open

Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers

(This special issue belongs to the Section Biochemistry)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2026 | 3 articles | Viewed by 8683 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines, adipokines, chemokines, epigenetics, microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

and

Vincenzo Piccolo

submission deadline 31 Dec 2026 | 5 articles | Viewed by 8350 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Biology: Infection and Pathology, Diagnosis and Treatment

edited by

Gergana Zahmanova

submission deadline 31 Dec 2026 | 7 articles | Viewed by 7952 | Submission Open

Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host–virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Tryptophan Metabolism

edited by

Katsunori Nonogaki

submission deadline 31 Dec 2026 | 2 articles | Viewed by 6354 | Submission Open

Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Liquid Biopsies in Oncology—3rd Edition

edited by

Sandra V. Fernandez

and

Carmela Paolillo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6226 | Submission Open

Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5831 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Plant Adaptation to Abiotic Stresses: Evolutionary, Multi-Omics, and Molecular Perspectives

edited by

Guang Chen

and

Qiufang Shen

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5659 | Submission Open

Keywords: plant; evolutionary adaptation; molecular evolution; abiotic stresses; stress tolerance; functional genomics; molecular regulatory network; genomics; transcriptomics; metabolomics; proteomics; epigenomics

(This special issue belongs to the Section Molecular Plant Sciences)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5630 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5416 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5307 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2026 | 1 articles | Viewed by 4939 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2026 | 5 articles | Viewed by 4872 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

The Interactions Between Nutrients and Adipose Tissue

edited by

Junseok Son

submission deadline 31 Dec 2026 | 5 articles | Viewed by 4649 | Submission Open

Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cardiovascular and Metabolic Pharmacology

edited by

Alma Martelli

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4578 | Submission Open

Keywords: cardiovascular pharmacology; metabolic pharmacology; hypertension; diabetes; obesity; atherosclerosis; hyperlipidemias; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Animal Molecular Genetics

edited by

Jarosław Króliczewski

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4295 | Submission Open

Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Natural Products in Drug Discovery: 2nd Edition

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4180 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4175 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4088 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell–cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4071 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 31 Dec 2026 | 7 articles | Viewed by 3997 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3958 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus–host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Advances in HIV Research: Molecular Basis and Potential Therapies

edited by

Sharilyn Almodovar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3832 | Submission Open

Keywords: human immunodeficiency virus; HIV prevention; HIV therapeutics; HIV vaccines; antiretroviral therapies; long-acting ART; HIV genetic therapy; HIV animal models; HIV in vitro models; viral reservoirs; HIV latency; HIV persistence; HIV evolution; HIV quasispecies; HIV proteins; HIV cure; HIV immunopathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Effects of Radiation on Human Cells and Tissues

edited by

Maria Paola Bertuccio

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3725 | Submission Open

Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity

(This special issue belongs to the Section Molecular Biology)

Pulmonary Fibrosis: Molecular Mechanisms and Therapeutic Strategies

edited by

Barbara Ruaro

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3579 | Submission Open

Keywords: machine learning; pulmonary fibrosis; interstitial lung diseases; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3486 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Sex and Gender Medicine—Physiology: A New Horizon in Human Physiology

edited by

Rosanna Mallamaci

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3403 | Submission Open

Keywords: sex and gender; personalized medicine; sex-specific evidence; sex-specific differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Flowers: Molecular and Genetic Regulation of Growth and Development

edited by Yaqin Wang

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3398 | Submission Open

Keywords: flower; growth and development; molecular regulation; genetic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Biotransformation and Engineering of Fungals and Microalgae

edited by

Alejandro Chamizo-Ampudia

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3385 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae–fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3201 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3113 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane–protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2051-2100 on page 42 of 63.

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