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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration

edited by Hyun Jin Shin

submission deadline 20 Apr 2026 | Viewed by 516 | Submission Open

Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Impact of the Biological Clock on Health and Disease

edited by

Bojlul Bahar

submission deadline 20 Apr 2026 | Viewed by 500 | Submission Open

Keywords: circadian rhythm; inflammation; oxidative stress; energy balance; metabolic syndrome; ageing; cancer; diabetes; obesity; entrainment; synchrony; melatonin

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Energy Metabolism in Cells and Tissues

edited by

Alexander Remels

submission deadline 20 Apr 2026 | Viewed by 454 | Submission Open

Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism

(This special issue belongs to the Section Molecular Biology)

Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition

edited by

Makoto Kimura

submission deadline 20 Apr 2026 | Viewed by 450 | Submission Open

Keywords: aflatoxins; trichothecenes; fumonisins; ochratoxins; host-specific toxins; Alternaria toxins; emerging mycotoxins; biosynthesis; gene cluster; transcriptional regulation; toxicity; modification; ecological role

(This special issue belongs to the Section Molecular Toxicology)

Nose-to-Brain Drug Delivery: Opportunities and Challenges

edited by

Daisuke Inoue

submission deadline 20 Apr 2026 | Viewed by 441 | Submission Open

Keywords: nose-to-brain drug delivery; brain drug delivery system; CNS diseases; intranasal administration; nasal formulation

(This special issue belongs to the Section Molecular Pharmacology)

Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation

edited by

Edyta Juszczuk-Kubiak

submission deadline 20 Apr 2026 | Viewed by 431 | Submission Open

Keywords: probiotics; gut microbiota; gut– brain axis; mental health

(This special issue belongs to the Section Molecular Biology)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 20 Apr 2026 | Viewed by 415 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 20 Apr 2026 | Viewed by 411 | Submission Open

Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Advanced Nanomaterials for Bone Regeneration and Osseointegration

edited by Cristian Covarrubias

submission deadline 20 Apr 2026 | Viewed by 396 | Submission Open

Keywords: nanomaterials; bone regeneration; osseointegration; bifunctional biomaterials; bioceramics; metal nanoparticles; metal-organic frameworks (MOFs); nanostructured surfaces; composite materials; tissue engineering

(This special issue belongs to the Section Molecular Nanoscience)

Nanotechnology in Drug Delivery: Applications and Perspectives

edited by Ádám Juhász

submission deadline 20 Apr 2026 | Viewed by 393 | Submission Open

Keywords: nanostructured materials; drug delivery; drug– carrier interactions; hydrogel; aerogels; associated colloids; surfactants; macromolecules; blood– brain barrier; controlled release

(This special issue belongs to the Section Molecular Nanoscience)

Preparations and Applications of Aerogels and/or Cryogels: From a Molecular Perspective

edited by

Angelika Kmita

and

Dorota Lachowicz

submission deadline 20 Apr 2026 | Viewed by 392 | Submission Open

Keywords: inorganic and/or organic aerogels; hybrid materials; eco-friendly materials; diagnosis

(This special issue belongs to the Section Materials Science)

New Advances in Genetic and Molecular Mechanisms Underlying Agronomic Traits in Crops

edited by Hongbin Zhang

submission deadline 20 Apr 2026 | Viewed by 378 | Submission Open

Keywords: agronomic traits; crops; vegetable crops; fruit trees; genetic; molecular; high-throughput sequencing; agronomic genes

(This special issue belongs to the Section Molecular Plant Sciences)

Attosecond Science: Toward Applications in Biology, Chemistry and Medicine

edited by

Predrag Ranitovic

submission deadline 20 Apr 2026 | Viewed by 374 | Submission Open

Keywords: ultrafast light– matter interaction; high-harmonic generation; strong-field ionization; free-electron laser (FEL) ultrafast sources

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanism of Diabetes and Its Complications

edited by Michishige Terasaki

submission deadline 20 Apr 2026 | Viewed by 363 | Submission Open

Keywords: diabetes; hyperglycemia; oxidative stress; atherosclerosis; comorbidity; complication; metabolic metabolic dysfunction associated steatotic liver disease (MASLD); steatohepatitis (MASH); chronic kidney disease (CKD); heart failure; heart failure with preserved ejection fraction (HFpEF); coronary artery disease (CAD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Photodiagnosis and Photodynamic Therapy

edited by

Tomasz Kubrak

and

David Aebisher

submission deadline 20 Apr 2026 | Viewed by 351 | Submission Open

Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Non-Conventional and Complementary Treatments for Inflammatory Bowel Disease

edited by Roberta Ottria and

Giovanni Maconi

submission deadline 20 Apr 2026 | Viewed by 347 | Submission Open

Keywords: inflammatory bowel disease; leaky gut; molecular mechanisms; inflammatory pathways; small molecules in inflammatory bowel disease; non-conventional treatment; complementary medicine; inflammatory cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases

edited by

Md. Jakaria

and

Jason Cannon

submission deadline 20 Apr 2026 | Viewed by 340 | Submission Open

Keywords: neurotoxicity; cellular stress; neuronal cell death; ferroptosis; neurodegeneration; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Immunocytes in Cancer and New Insights into Immunotherapy

edited by Ida Franiak-Pietryga

submission deadline 20 Apr 2026 | Viewed by 334 | Submission Open

Keywords: T cells; B cells; NK cells; adoptive cell therapy; cancer; immunotherapy; checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Molecular Studies in Gynecological Oncology: Advancing Diagnosis and Treatment

edited by

Ivonne Nel

submission deadline 20 Apr 2026 | Viewed by 332 | Submission Open

Keywords: biomarker; cancer screening; clinical trial; DNA repair; invasion; metastasis; methylation; molecular diagnostics; molecular tumor pathology; next-generation sequencing; omics; personalized medicine; prognosis; single-cell analysis; targeted therapy; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

The Role of Macrophages in Inflammation and Cancer: An Update

edited by

José Luis Reyes

submission deadline 20 Apr 2026 | Viewed by 329 | Submission Open

Keywords: macrophages; cancer; inflammation; cell therapy

(This special issue belongs to the Section Molecular Immunology)

Advanced Research on Malaria: Molecular and Biochemical Perspectives

edited by

Pedro Eduardo Ferreira

submission deadline 20 Apr 2026 | Viewed by 324 | Submission Open

Keywords: malaria; vectors; therapies; resistance; cellular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Nanoparticle Systems for Cancer Phototherapy

edited by

Maria Raposo

submission deadline 20 Apr 2026 | Viewed by 312 | Submission Open

Keywords: nanoparticles; phototherapy; cancer; photodynamic therapy; photosensitiser molecules; biomolecules damage; DNA-intercalators; oxidative stress; cell/tissue specificity; drug delivery systems

(This special issue belongs to the Section Molecular Oncology)

Chlamydia trachomatis Pathogenicity and Disease (Third Edition)

edited by

Rosa Sessa

and

Marisa Di Pietro

submission deadline 20 Apr 2026 | Viewed by 296 | Submission Open

Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unveiling Molecular Mysteries of Brain Barriers

edited by Ana Catarina Duarte

submission deadline 20 Apr 2026 | Viewed by 288 | Submission Open

Keywords: blood– brain barrier; blood– cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters

(This special issue belongs to the Section Molecular Neurobiology)

Plant Genomics and Genome Editing, 3rd Edition

edited by

Hikmet Budak

submission deadline 20 Apr 2026 | Viewed by 287 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Selected Papers from the 1st RNA and RNase International Meeting and Related Research

edited by

Ester Boix

submission deadline 20 Apr 2026 | Viewed by 283 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Biochemistry)

Current Molecular Advances in Apoptosis

edited by

Mariarosaria Boccellino

and

Davide Viggiano

submission deadline 20 Apr 2026 | Viewed by 277 | Submission Open

Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria

edited by Maria Del Carmen Muñoz-Egea

submission deadline 20 Apr 2026 | Viewed by 276 | Submission Open

Keywords: mycobacteria; nontuberculous mycobacteria; Mycobacterium tuberculosis; antimicrobial resistance; drug resistance mechanisms; molecular mechanisms; antibiotic resistance

(This special issue belongs to the Section Molecular Microbiology)

Application of NMR Spectroscopy in Biomolecules: 2nd Edition

edited by

Luigi Russo

submission deadline 20 Apr 2026 | Viewed by 264 | Submission Open

Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins; peptides; and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein– ligand; protein– DNA; protein– RNA interaction; protein folding and misfolding; structure-based drug screening; fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies

(This special issue belongs to the Section Molecular Biophysics)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 20 Apr 2026 | Viewed by 258 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 20 Apr 2026 | Viewed by 255 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Immunopathogenesis and Novel Therapeutic Strategies for Systemic Lupus Erythematosus: Third Edition

edited by

Marzena Olesińska

and Hanna Przepiera-Bȩdzak

submission deadline 20 Apr 2026 | Viewed by 254 | Submission Open

Keywords: systemic lupus erythematosus; SLE pathogenesis; the epigenetic regulation of lupus; the genetic background of SLE; interferon; cytokine networks; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

The Anti-Inflammatory and Antioxidant Potential of Phytochemicals

edited by

Woo-Sik Jeong

submission deadline 20 Apr 2026 | 1 articles | Viewed by 251 | Submission Open

Keywords: phytochemicals; dietary bioactives; inflammation; natural compounds; functional foods; oxidative stress; cytokine modulation; NF-κ B signaling; chronic diseases; plant-derived metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protection of Natural Products in Liver Injury

edited by

Jeon-Ok Moon

submission deadline 20 Apr 2026 | Viewed by 249 | Submission Open

Keywords: liver injury; natural product; antioxidant activity; modulation of inflammatory pathway; mitigation of fibrosis; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Translational Neuroscience of Emotion, Cognition, and Behavior: From Mechanisms to Mental Health

edited by

Masaru Tanaka

submission deadline 20 Apr 2026 | Viewed by 245 | Submission Open

Keywords: translational neuroscience; emotion and cognition; neurobehavioral mechanisms; mental health biomarkers; Neuroimmunology; brain– gut axis; optogenetics and behavior; single-cell transcriptomics; psychiatric disorders; neuromodulation therapies

(This special issue belongs to the Section Molecular Neurobiology)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 20 Apr 2026 | Viewed by 244 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Magnetic Materials: Synthesis, and Applications

edited by Artur Chrobak

submission deadline 20 Apr 2026 | Viewed by 243 | Submission Open

Keywords: magnetic materials; properties; synthesis; applications

(This special issue belongs to the Section Materials Science)

Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies

edited by

Andrea Dalbeni

submission deadline 20 Apr 2026 | Viewed by 242 | Submission Open

Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Apr 2026 | Viewed by 241 | Submission Open

Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The New Developments in Third-Generation Sequencing Methods in Human Rare Diseases

edited by

Rick Kamps

submission deadline 20 Apr 2026 | Viewed by 234 | Submission Open

Keywords: short-read sequencing; long-read sequencing; single-cell rna sequencing; spatial-transcriptomic sequencing; single-nucleotide sequencing; structural-variant sequencing; protein-omics sequencing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives

edited by

Katarzyna E. Stȩpnik

submission deadline 20 Apr 2026 | Viewed by 233 | Submission Open

Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Reproduction and Reproductive Diseases

edited by

Sung Tae Kim

submission deadline 20 Apr 2026 | Viewed by 233 | Submission Open

Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanosensitive Ion Channels in the Nervous System

edited by

Rashid Giniatullin

submission deadline 20 Apr 2026 | Viewed by 229 | Submission Open

Keywords: mechanosensitive ion channels; Piezo1; Piezo2; mechanosensitive K2P channels; mechanical pain; pulsating blood flow; tissue stiffness; mechanobiology of glymphatic system; chemical agonists of mechanosensitive channels; mechanosensitive TRP channels; neuron; glial cells

(This special issue belongs to the Section Molecular Neurobiology)

Immunological Regulation as Determinant of Outcomes in Critically Sick Patients

edited by

Krzysztof Laudanski

submission deadline 20 Apr 2026 | Viewed by 218 | Submission Open

Keywords: critical illness; outcome; immune system; inflammation; homeostasis; epigenetic; microbiome; central nervous system; dysregulation; recovery

(This special issue belongs to the Section Molecular Immunology)

Hyaluronan and Proteoglycans in Cancer and Inflammatory Diseases: Molecular Mechanisms and Therapeutic Implications

edited by Angela D’Ascola and

Michele Scuruchi

submission deadline 20 Apr 2026 | Viewed by 216 | Submission Open

Keywords: hyaluronan; proteoglycans; inflammation; cancer; tumor microenvironment; therapy

(This special issue belongs to the Section Molecular Oncology)

Serum Amyloid A: Established Roles and Emerging Questions in Health and Disease

edited by Preetha Shridas

submission deadline 20 Apr 2026 | Viewed by 215 | Submission Open

Keywords: Serum Amyloid A; high-density lipoprotein; acute inflammation; chronic inflammatory

(This special issue belongs to the Section Biochemistry)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 20 Apr 2026 | Viewed by 213 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Apr 2026 | Viewed by 211 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 20 Apr 2026 | Viewed by 210 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes

edited by