Chlamydia trachomatis Pathogenicity and Disease (Third Edition)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 10 October 2025
Special Issue Editors
Interests: Chlamydia; host defence factors; genital infection;pathogenesis of male infertility; Chlamydia-host cell interaction; new anti-Chlamydial drugs; chronic inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Interests: clinical microbiology; Chlamydia; bacterial pathogenesis; pathogen-host interactions; infection and cardiovascular diseases; cervicovaginal microbiota;biofilm; in vitro susceptibility testing; antibacterial agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chlamydia trachomatis, responsible for genital infection, trachoma, and lymphogranuloma venereum, according to the specific serotype, is still a relevant public health problem worldwide due to the high prevalence of asymptomatic infections in both women and men, favoring the onset of chronic complications, such as pelvic inflammatory disease and ectopic pregnancy for women, epididymitis and proctitis for men, and reactive arthritis and infertility for both sexes. These complications are likely due to the long-term persistence of C. trachomatis infection in the host organism, leading to a chronic inflammatory state and consequent tissue damage.
To date, many critical questions on the pathogenesis of C. trachomatis infection remain to be answered. For example, the nature of the host innate immune response to C. trachomatis, as well as the virulence factors involved, warrants further investigation to clarify the molecular and cellular mechanisms responsible for tissue damage associated with chlamydial infection.
To shed light on the etiopathogenesis and host cell response mechanisms of damaging C. trachomatis infection, this Special Issue covers current progress in chlamydial infection pathogenesis and related diseases.
Dr. Rosa Sessa
Dr. Marisa Di Pietro
Guest Editors
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Keywords
- Chlamydia trachomatis
- virulence factors
- host susceptibility or resistance
- innate and adaptive immune responses
- genetic studies
- cervico-vaginal microbiota
- clinical outcomes with molecular study
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