Molecular Research on the Regulation of Expression Associated with the Mechanism of Multidrug Resistance in Mycobacterium tuberculosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 143
Special Issue Editor
Special Issue Information
Dear Colleagues,
Infections caused by multidrug-resistant strains of Mycobacterium tuberculosis remain a major public health problem worldwide, and these strains pose a major treatment challenge. There are an increasing number of cases of multidrug-resistant tuberculosis (TB), which do not respond to the existing first-line antituberculosis drugs such as rifampicin and isoniazid. In addition, extensively drug-resistant (XDR) strains of TB do not respond even to the most effective second-line anti-TB drugs. It is therefore urgent to identify the mechanisms of resistance of multidrug-resistant tuberculosis and to develop antituberculosis drugs that are effective against MDR and XDR strains.The regulatory mechanisms underlying the emergence of multidrug-resistant strains have not yet been fully elucidated, and further research is needed to develop better TB control strategies. To understand the mechanisms involved in the multidrug resistance of this pathogen, studies have been conducted to identify differentially expressed genes, associated gene networks, and signaling cascades involved in multidrug resistance. Other studies have investigated the microRNA expression profile of M. tuberculosis strains and examined the differences between sensitive and resistant strains using next-generation sequencing. It has also been shown that efflux pumps may play an important role in acquired resistance in MDR strains. Basal expression levels of some efflux pump genes are higher in MDR isolates than in pan-sensitive isolates, and differences in basal expression may be useful in diagnosing and treating resistant tuberculosis.
Dr. Maria Del Carmen Muñoz-Egea
Guest Editor
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Keywords
- multidrug resistance
- MDR
- XDR
- Mycobacterium tuberculosis
- molecular research
- gene expression
- genome sequencing
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