The Role of Macrophages in Inflammation and Cancer: An Update
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 2258
Special Issue Editor
Special Issue Information
Dear Colleagues,
Macrophages are cells of myeloid origin residing in virtually all parts of human body. To perform their important roles, macrophages can either be expanded by self-renewal progenitors positioned at strategic organs or be recruited from bone marrow or other macrophage pools. Therefore, macrophages are indeed subpopulations of distinct origin, which enable them to display a great variety of, often contrasting, functions, including immunosurveillance, tissue homeostasis and repair, promoters of inflammation, pathogen clearance, and pro- and anti-oncogenic roles. Thus, these cells are highly plastic, adapting themselves to the environment encountered, which in turn largely influences disease outcomes. The opportunity to manipulate macrophages has long been seen as a potential therapy; however, our understanding of macrophage immunobiology is incomplete, and research is required to update and spread the knowledge, which will ultimately allow us to treat diseases using macrophage-based approaches.
We are pleased to invite you to submit original research articles and reviews related to research areas such as (but not limited to) macrophage immunometabolism in cancer, immunosuppressive features displayed by macrophages in cancer, and macrophages as modulators of tumor-infiltrating immune cell types, altered signaling in macrophages during carcinogenesis, macrophage programs as cancer prognosis markers, and macrophages as sources of growth/angiogenic factor release.
We look forward to receiving your contributions.
Dr. José Luis Reyes
Guest Editor
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Keywords
- macrophages
- cancer
- inflammation
- cell therapy
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