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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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HIV Infection, Pathogenesis and Treatment
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 551 | Submission Open
Keywords: HIV Infection; HIV; host immune responses; pathogenesis
(This special issue belongs to the Section Molecular Microbiology)
Oral Fibrosis and Oral Cancers: From Molecular Targets to Therapeutics
edited by Ila Pant
submission deadline 31 Jan 2026 | Viewed by 526 | Submission Open
Keywords: OSF; oral cancer; myofibroblast activation; collagen homeostasis; cancer stem cells; immunotherapy; monoclonal antibodies; DNA or RNA based targeted therapy; small molecule inhibitors; targeted nano-delivery systems; resistance to targeted therapies; molecular targets; natural compounds
(This special issue belongs to the Section Molecular Oncology)
The Interactions Between Nutrients and Adipose Tissue
edited by
submission deadline 31 Jan 2026 | Viewed by 511 | Submission Open
Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Antitumor Activity of Natural Product
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 498 | Submission Open
Keywords: natural products; cancer treatment; cancer prevention; medicinal plants; medicinal mushrooms
(This special issue belongs to the Section Molecular Oncology)
The Application of an Electron Microscope in the Study of Cell Structure
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 483 | Submission Open
Keywords: intracellular structure; organelles; cell surface structure; immuno-labeling
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms of Thromboinflammation
edited by Ana B. Arroyo
submission deadline 31 Jan 2026 | Viewed by 463 | Submission Open
Keywords: thromboinflammation; coagulation; inflammation; immune system; sepsis; stroke; autoimmune diseases; cancer; hematology; biomarkers; translational medicine
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into Recent Research in Composite Materials
edited by Aboulfazl Barati
submission deadline 31 Jan 2026 | Viewed by 440 | Submission Open
Keywords: composite materials; molecular-level structure– property relationships; polymer nanocomposites; interfacial interactions; sustainable and biodegradable composites; hybrid organic– inorganic systems
(This special issue belongs to the Section Materials Science)
Plant Responses to Abiotic Stress: Mechanisms and Adaptations submission deadline 31 Jan 2026 | Viewed by 427 | Submission Open
Keywords: salinity stress; heat and cold stress; oxidative stress; signal transduction; stress-responsive genes; antioxidant defence mechanisms; hormonal regulation; molecular adaptation; epigenetic regulation; plant-microbe interaction; crop improvement; stress-resilient plants
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Melanoma Immunotherapy and Molecular Mechanisms of Drug Resistance, Second Edition
edited by Antonino Guerrisi and
submission deadline 31 Jan 2026 | Viewed by 425 | Submission Open
Keywords: melanoma; targeted therapy; immunotherapy; precision medicine; biomarkers; omics technologies; tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy
edited by Laura Necula
submission deadline 31 Jan 2026 | 1 articles | Viewed by 355 | Submission Open
Keywords: gastrointestinal cancers; biomarkers; early diagnosis; circulating molecules; non-invasive tests
(This special issue belongs to the Section Molecular Oncology)
Molecular Design and Functional Applications of Polysaccharide Composites submission deadline 31 Jan 2026 | 1 articles | Viewed by 337 | Submission Open
Keywords: polysaccharide composites; molecular design; functional applications
(This special issue belongs to the Section Materials Science)
Novel Mechanisms of Receptor Activation
edited by
submission deadline 31 Jan 2026 | Viewed by 302 | Submission Open
Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs
(This special issue belongs to the Section Biochemistry)
Advanced Strategies for Melanoma Immunotherapy submission deadline 31 Jan 2026 | Viewed by 257 | Submission Open
Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Fine-Tuning Proteostasis: Insights into Ubiquitination and Deubiquitination Pathways
edited by
submission deadline 31 Jan 2026 | Viewed by 254 | Submission Open
Keywords: deubiquitination; homeostasis; posttranslational modification; proteasomal degradation; protein quality control; proteolysis; proteostasis; signaling pathway; small molecule; ubiquitin-proteasome system; ubiquitination
(This special issue belongs to the Section Biochemistry)
Novel Heterocyclic Bioactive Compounds: Design, Synthesis and Biological Evaluation
edited by
submission deadline 31 Jan 2026 | Viewed by 234 | Submission Open
Keywords: heterocyclic compounds; drug design; medicinal chemistry; bioactive molecules; structure– activity relationships; synthetic methodologies; molecular mechanisms of action; pharmacological evaluation; therapeutic agents
(This special issue belongs to the Section Biochemistry)
Coordination Chemistry: From Fundamental Principles to Multifunctional Applications
edited by
submission deadline 31 Jan 2026 | Viewed by 213 | Submission Open
Keywords: coordination compounds; metal– ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal– organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Angiogenin: From Molecular Mechanisms to Clinical Implications
edited by
submission deadline 31 Jan 2026 | Viewed by 211 | Submission Open
Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target
(This special issue belongs to the Section Biochemistry)
Advances in Research of Estrogen Receptors in Health and Diseases submission deadline 31 Jan 2026 | Viewed by 199 | Submission Open
Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders
(This special issue belongs to the Section Biochemistry)
Sphingolipids in Infections, Disorders and Diseases
edited by Elita Avota
submission deadline 31 Jan 2026 | Viewed by 197 | Submission Open
Keywords: sphingolipids; sphingolipid biosynthesis; sphingolipidoses; metabolic disorders; infections; lipidomics; sphingolipid targeting drugs
(This special issue belongs to the Section Biochemistry)
Emerging Therapeutic Potential of Organic Compound in Diseases submission deadline 31 Jan 2026 | Viewed by 186 | Submission Open
Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics submission deadline 31 Jan 2026 | Viewed by 185 | Submission Open
Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics; metabolomics; proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics
(This special issue belongs to the Section Molecular Biology)
Biopolymer-Based Materials: Synthesis, Characterization and Applications for a Sustainable Future submission deadline 31 Jan 2026 | Viewed by 185 | Submission Open
Keywords: biodegradable polymers; biopolymers; biopolymer-based composite materials; synthesis and characterization of biopolymer materials; applications of biopolymers and biopolymer-based composites
(This special issue belongs to the Section Materials Science)
Research Progress of Fluorescent Proteins in Molecular Biology
edited by Matteo Grenzi
submission deadline 31 Jan 2026 | Viewed by 180 | Submission Open
Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques
(This special issue belongs to the Section Molecular Biology)
Inner Ear Disorders: From Molecular Mechanisms to Treatment
edited by
submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open
Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects
(This special issue belongs to the Section Molecular Immunology)
Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 177 | Submission Open
Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research
(This special issue belongs to the Section Molecular Informatics)
Molecular Research on Zoonotic Diseases: Current Advances and Perspectives submission deadline 31 Jan 2026 | Viewed by 165 | Submission Open
Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 5th Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open
Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Role of Cytoskeletal Proteins in Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 160 | Submission Open
Keywords: cytoskeleton; microtubules; actin filaments; intermediate filaments; neurodegeneration; cancer metastasis; cell migration; cellular mechanotransduction; cytoskeletal remodeling
(This special issue belongs to the Section Molecular Biology)
Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies
edited by Juliana Luporini Dreyfuss
submission deadline 31 Jan 2026 | Viewed by 159 | Submission Open
Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Brain Tumor Research and Treatment submission deadline 31 Jan 2026 | Viewed by 153 | Submission Open
Keywords: brain tumor; gliomas; brain metastases; translational research; molecular biology
(This special issue belongs to the Section Molecular Oncology)
Long COVID Biology and Epidemiology: Predisposition, Molecular Mechanisms and Diagnostics
edited by Eduardo José Melo dos Santos
submission deadline 31 Jan 2026 | Viewed by 151 | Submission Open
Keywords: long COVID; genetic predisposing; long COVID epidemiology; pathogenesis; immunology of long COVID; long COVID etiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Animal Nutrition and Muscle Biology
edited by Usuk Jung
submission deadline 31 Jan 2026 | Viewed by 148 | Submission Open
Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis
(This special issue belongs to the Section Molecular Biology)
Macrophage Metabolic Reprogramming in Inflammation submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open
Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages
(This special issue belongs to the Section Molecular Immunology)
Breakthroughs in Anti-Cancer Agents Discovery
edited by
submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open
Keywords: medicinal chemistry; drug discovery; cancer; anti-cancer agents; synthesis; bioactive molecules; biological evaluation; computational drug discovery; artificial intelligence
(This special issue belongs to the Section Molecular Oncology)
Unraveling Cell–Cell and Cell–Matrix Interactions: Novel Morphological and Molecular Insights
edited by
submission deadline 31 Jan 2026 | Viewed by 143 | Submission Open
Keywords: DGC; sarcoglycans; cell– cell interactions; cell– matrix interactions; morphological analysis; molecular analysis; molecular pathogenesis; translational studies
(This special issue belongs to the Section Molecular Biology)
Structure, Properties, and Applications of Carbon Materials submission deadline 31 Jan 2026 | Viewed by 140 | Submission Open
Keywords: carbon-based structures; diamonds; carbon quantum dots; carbon composites; graphene; nanotubes
(This special issue belongs to the Section Materials Science)
Natural Products and Compounds in Anticancer Drug Discovery
edited by
submission deadline 31 Jan 2026 | Viewed by 138 | Submission Open
Keywords: antitumor plant compounds; antitumor plant-derived products; cellular pathways for natural drug apoptosis induction; chromatography of antitumor plant metabolites; modern technologies for recovery of plant anticancer substances; nanotechnology based natural anticancer drug products; plant-derived antitumor drug-protein interactions
(This special issue belongs to the Section Molecular Pharmacology)
Nutrition from Cereal Foods: Molecular Perspectives
edited by
submission deadline 31 Jan 2026 | Viewed by 138 | Submission Open
Keywords: cereal nutrition; molecular bioavailability; plant proteins; foodomics; grain processing; bioactive compounds; gut microbiome; nutraceuticals; food matrices; sustainable foods
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Pregnancy-Related Complications: Molecular Pathogenesis and Therapeutic Strategies
edited by
submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open
Keywords: pregnancy-related complications; placental dysfunction; maternal-fetal communication; extracellular vesicles; translational research; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
3D Scaffolds for Tissue Engineering: Challenges and Breakthroughs
edited by
submission deadline 31 Jan 2026 | Viewed by 130 | Submission Open
Keywords: 3D scaffolds; tissue engineering; biomaterials
(This special issue belongs to the Section Materials Science)
Cardiomyocytes Among Physiology and Pathophysiology: Molecular Insights and Therapeutic Implications
edited by Rosetta Ragusa and
submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open
Keywords: sarcomere; metabolic stress; epigenetic mechanisms; exercise; aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of the Aging Process: 2nd Edition submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: aging process; molecular mechanisms; epigenetic clock; cancer; metabolic disease
(This special issue belongs to the Section Molecular Biology)
Regulation of the Intestinal Barrier and the Brain-Gut Microbiota Axis: Role of Age, Gender, and Sex submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: age; brain– gut microbiota axis; intestinal barrier; fetal; gender; sex
(This special issue belongs to the Section Molecular Biology)
New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids
edited by and Peng Cao
submission deadline 31 Jan 2026 | Viewed by 128 | Submission Open
Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics
(This special issue belongs to the Section Molecular Nanoscience)
Recent Advances in Medicinal Plants and Natural Products: Second Edition submission deadline 31 Jan 2026 | Viewed by 124 | Submission Open
Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Advances in Molecular Imaging and Therapy
edited by
submission deadline 31 Jan 2026 | Viewed by 124 | Submission Open
Keywords: molecular imaging; therapy; clinical translation; precision medicine; radiotheranostics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Health-Promoting Benefits of Natural Products and Functional Foods, 2nd Edition
edited by
submission deadline 31 Jan 2026 | Viewed by 124 | Submission Open
Keywords: natural products; functional foods; health promotion; nutrigenomics; evidence-based preventive healthcare; phytochemicals; biomarkers; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nanomedicine for Cancer Diagnosis and Therapy
edited by
submission deadline 31 Jan 2026 | Viewed by 121 | Submission Open
Keywords: nanomaterials; multifunctional properties; anticancer nanotechnology; image guided nano platforms; in vivo evaluation; delivery approaches; immune-nanomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms and Combinatorial Strategies in Anti-Obesity Therapeutics submission deadline 31 Jan 2026 | Viewed by 120 | Submission Open
Keywords: obesity; high-fat diet; rodents; pharmacotherapy; body weight; food intake
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant-Based Early Therapeutics for Parasitic Infections Combined with Functional Modern Diagnosis Methods
edited by
submission deadline 31 Jan 2026 | Viewed by 120 | Submission Open
Keywords: active phytocompounds; antiparasitic agents; artificial intelligence; early diagnosis early treatment; life cycle; medicinal plants; parasite and vector; phytogenic feed additives; vision recognition
(This special issue belongs to the Section Molecular Plant Sciences)
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