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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Zoology

edited by

Valeria Maselli

submission deadline 20 Jan 2026 | 9 articles | Viewed by 12044 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog

(This special issue belongs to the Section Molecular Biology)

Editorial Board Members’ Collection Series: Cardiovascular Diseases

edited by

Melania Gaggini

and

Cristina Vassalle

submission deadline 20 Jan 2026 | 5 articles | Viewed by 11969 | Submission Open

Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis

edited by

Hidemasa Bono

submission deadline 20 Jan 2026 | 4 articles | Viewed by 11840 | Submission Open

Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases

(This special issue belongs to the Section Molecular Informatics)

Molecular Progression of Genetics in Breeding of Farm Animals

edited by

Karel Novák

submission deadline 20 Jan 2026 | 6 articles | Viewed by 11193 | Submission Open

Keywords: farm animal; livestock; genome sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Aspects of Bacterial Infection

edited by

María Soledad Ramírez

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10708 | Submission Open

Keywords: bacterial pathogenesis; antimicrobial resistance; molecular mechanism of host-pathogen interaction; biofilm; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10619 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 3 articles | Viewed by 10506 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10491 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Molecular Forensic Pathology and Toxicology: An Update

edited by

Angelo Montana

submission deadline 20 Jan 2026 | 5 articles | Viewed by 10375 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Neurologic and Neurodegenerative Disorders

edited by

Ioana-Miruna Balmus

and

Ioannis Mavroudis

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10237 | Submission Open

Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 Jan 2026 | 4 articles | Viewed by 9722 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition

edited by

Hsinjung Ho

submission deadline 20 Jan 2026 | 5 articles | Viewed by 9713 | Submission Open

Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic

(This special issue belongs to the Section Biochemistry)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 Jan 2026 | 1 articles | Viewed by 9475 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Natural Compounds in Human Health and Disease

edited by

Kazuhiko Nakadate

submission deadline 20 Jan 2026 | 4 articles | Viewed by 9433 | Submission Open

Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 9373 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 20 Jan 2026 | 5 articles | Viewed by 9319 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8794 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8525 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition

edited by

Paramjit S. Tappia

and

Bram Ramjiawan

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8260 | Submission Open

Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8247 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 20 Jan 2026 | 3 articles | Viewed by 8036 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Electrochemical-Related Materials

edited by Celia García-Hernandez

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7677 | Submission Open

Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications

(This special issue belongs to the Section Materials Science)

Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition

edited by

Martin Bartas

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7615 | Submission Open

Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Bone and Soft Tissue Tumors

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7466 | Submission Open

Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

New Insights into the Immunopathology of Infectious Diseases

edited by Marta Camici

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7294 | Submission Open

Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis

(This special issue belongs to the Section Molecular Immunology)

Latest Research on Plant Genomics and Genome Editing, 2nd Edition

edited by

Fabrizio Carbone

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7090 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7069 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials for Drug Delivery and Advanced Therapies

edited by

Annalisa Bianchera

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7040 | Submission Open

Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration

(This special issue belongs to the Section Materials Science)

Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications

edited by

Christian Julien

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6967 | Submission Open

Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries

(This special issue belongs to the Section Materials Science)

Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy

edited by Masahito Nakazaki

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6890 | Submission Open

Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease

(This special issue belongs to the Section Biochemistry)

Oxidative Stress in Human Diseases

edited by

Galina Nikolova

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6787 | Submission Open

Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers

(This special issue belongs to the Section Biochemistry)

Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets

edited by

Natalie Nieuwenhuizen

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6722 | Submission Open

Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6694 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition

edited by

Andrea Paola Rojas Gil

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6682 | Submission Open

Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 5 articles | Viewed by 6675 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies

edited by

Maria Teresa Sciortino

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6590 | Submission Open

Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6400 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies

edited by Emilio Vanoli and Eugenio Caradonna

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6308 | Submission Open

Keywords: heart failure; autonomic nervous system; brain– gut interaction; gut microbiota; neurohumoral treatment; cardiac remodeling; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6229 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Adult Stem Cell Research

edited by Dongsu Park

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5937 | Submission Open

Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging

(This special issue belongs to the Section Molecular Biology)

Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies

edited by

Mariarosaria Boccellino

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5933 | Submission Open

Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Landscape of Pulmonary Arterial Hypertension

edited by Cármen Brás-Silva

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5931 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Parkinson's Disease

edited by

Yi-Chuan Cheng

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5846 | Submission Open

Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment

edited by

Peteris Tretjakovs

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5819 | Submission Open

Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Research Insights in Cystic Fibrosis and CFTR-Related Diseases

edited by Judith A. Coppinger

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5786 | Submission Open

Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Drug Discovery and Synthesis: 2nd Edition

edited by

Lidia Ciccone

and

Susanna Nencetti

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5774 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Diagnostics and Treatment Advances in Lung Diseases

edited by Eirini Vasarmidi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5767 | Submission Open

Keywords: lung diseases; pulmonary; alveolar; diagnosis; treatment; biomarkers; molecular; bronchoalveolar lavage; genetics; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5737 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment

edited by

Marco Valerio Mariani

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5631 | Submission Open

Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fat and Obesity: Molecular Mechanisms and Pathogenesis

edited by

Seon-Yong Jeong

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5549 | Submission Open

Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 801-850 on page 17 of 67.

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