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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Nano-Based Drug Delivery and Theranostic Systems

edited by

Mukesh Meher

and

Yapei Zhang

submission deadline 20 May 2026 | Viewed by 166 | Submission Open

Keywords: nanoparticles; smart drug/gene delivery; multifunctional nanoparticles; theranostics; targeted therapy; molecular imaging; cancer

(This special issue belongs to the Section Molecular Nanoscience)

Functional Genomics and Computational Biology of Horticultural Plants

edited by

Claudio Pugliesi

submission deadline 20 May 2026 | Viewed by 164 | Submission Open

Keywords: transcriptomics; computational model; genome editing; GWAS; multi-omics; NGS technologies; MAS; genomic selection; mutagenesis; RNA-silencing

(This special issue belongs to the Section Molecular Plant Sciences)

Extracellular Vesicles in Microorganisms

edited by

Bao-Hong Lee

and

Tang-Long Shen

submission deadline 20 May 2026 | Viewed by 163 | Submission Open

Keywords: microbial extracellular vesicles; outer membrane vesicles; host– microbe interaction; interkingdom communication; EV cargo; microbial therapeutics; microbiota; nanovesicles; small RNAs; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Biometallic Nanoparticles: Synthesis, Functionalization and Multidisciplinary Applications

edited by

Elvira Rozhina

submission deadline 20 May 2026 | Viewed by 162 | Submission Open

Keywords: biogenic nanomaterials; antibacterial agents; plant extracts; biogenic silver nanoparticles; biofilms; cytotoxicity

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Porous Polymers

edited by Bolin Ji

submission deadline 20 May 2026 | Viewed by 161 | Submission Open

Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment

(This special issue belongs to the Section Materials Science)

New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Diana Torge

submission deadline 20 May 2026 | Viewed by 159 | Submission Open

Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition

edited by

Luís Belo

and

Márcia Carvalho

submission deadline 20 May 2026 | Viewed by 158 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; toxicity mechanisms; inflammation; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chlorophylls and Carotenoids: Metabolism and Regulation in Plants

edited by

Shan Lu

submission deadline 20 May 2026 | Viewed by 156 | Submission Open

Keywords: chlorophyll; carotenoid; metabolism; regulation; evolution; coordination

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research and Immune Landscape of Breast Cancer

edited by

Robson Monteiro

submission deadline 20 May 2026 | Viewed by 150 | Submission Open

Keywords: breast cancer; immune landscape; single-cell analysis; omics; therapy resistance; metastasis

(This special issue belongs to the Section Molecular Immunology)

The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart

edited by

Ofer Binah

submission deadline 20 May 2026 | Viewed by 148 | Submission Open

Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine

edited by

Emi Shimizu

and

Motoki Okamoto

submission deadline 20 May 2026 | Viewed by 143 | Submission Open

Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Understanding and Combating Antimicrobial Resistance: Molecular Insights and Innovative Approaches

edited by

Giovanni Di Bonaventura

submission deadline 20 May 2026 | Viewed by 135 | Submission Open

Keywords: genetic mutations; horizontal gene transfer; efflux pump mechanisms; biofilm formation; novel antibiotic development; antimicrobial peptides; phage therapy; CRISPR-based tools; antimicrobial stewardship programs

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases

edited by

Eiko Nakamaru-Ogiso

submission deadline 20 May 2026 | Viewed by 130 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulatory Mechanisms in Kidney Development and Function

edited by Gary F. Gerlach

submission deadline 20 May 2026 | Viewed by 128 | Submission Open

Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN

(This special issue belongs to the Section Molecular Biology)

Molecular Evolution and Genetic Diversity in Viruses

edited by

Jennifer H. Lun

submission deadline 20 May 2026 | Viewed by 117 | Submission Open

Keywords: viral mutation; recombination reassortment; viral genomics; quasispecies dynamics; antiviral resistance; viral phylogenetics; zoonotic transmission; genomic surveillance

(This special issue belongs to the Section Molecular Microbiology)

T Cell Malignancies: Translating Basic Research into Better Therapy

edited by

Grzegorz Przybylski

submission deadline 20 May 2026 | Viewed by 96 | Submission Open

Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights in Renal and Epithelial Physiology

edited by Pedro A. Jose

submission deadline 20 May 2026 | Viewed by 94 | Submission Open

Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance

(This special issue belongs to the Section Molecular Biology)

Latest Research in Alzheimer’s Disease

edited by

Prashant R Bharadwaj

submission deadline 20 May 2026 | Viewed by 91 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative disease; disease diagnosis; biomarker development; drug development; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Innovative Nano- and Microcarrier Systems for Targeted Delivery

edited by

Matteo Perra

submission deadline 20 May 2026 | Viewed by 91 | Submission Open

Keywords: drug delivery systems; nanocarriers; microcarriers; targeted delivery; controlled release; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Artificial Intelligence and Data Science-Driven Biomarker Discovery in Neurodegenerative Diseases

edited by

Andrzej Kloczkowski

and

Mubashir Hassan

submission deadline 20 May 2026 | Viewed by 71 | Submission Open

Keywords: large language models; big data analytics; Alzheimer’ s disease; Parkinson disease; neurodegeneration; neurogenerative disease; disease diagnosis; biomarker development; drug development

(This special issue belongs to the Section Molecular Informatics)

Smart and Sustainable Hydrogels for Environmental Applications

edited by Rolando Chamy

submission deadline 20 May 2026 | Viewed by 18 | Submission Open

Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine

(This special issue belongs to the Section Materials Science)

The Design, Synthesis, and Application of Functional Porous Materials

edited by Qinhe Pan,

Shenzhen Chang

and

Shi-Cheng Wang

submission deadline 20 May 2026 | Viewed by 16 | Submission Open

Keywords: porous materials; functional guest species; functionalization; luminescence; electrochemistry; stimulus response; adsorption; sensing; photoelectric; catalysis

(This special issue belongs to the Section Materials Science)

Environmental Microorganisms and Pathogen Infections

edited by

Jadwiga Wyszkowska

and

Magdalena Zaborowska

submission deadline 20 May 2026 | Viewed by 13 | Submission Open

Keywords: environmental microbiome; pathogens; resistance genes; molecular adaptation; microbial interactions; anthropogenic pollution; functional gene expression; ecosystem health

(This special issue belongs to the Section Molecular Microbiology)

Plant Extracts and Their Biological Activities: In Vitro and In Vivo

edited by

Ângelo Luís

submission deadline 20 May 2026 | Viewed by 11 | Submission Open

Keywords: plant extracts; bioactive compounds; molecular mechanisms; in vitro and in vivo studies; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research and Cellular Biology of Breast Cancer: 2nd Edition

edited by

Andrea Nicolini

and

Cristian Scatena

submission deadline 20 May 2026 | Viewed by 9 | Submission Open

Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor; immune responses; conventional and biological therapies; blood and tissue biomarkers

(This special issue belongs to the Section Molecular Oncology)

Tissue Engineering and Advanced Biomaterials for Regenerative Medicine

edited by

Hak Soo Choi

Motoichi Kurisawa

and

Joo Eun Chung

submission deadline 20 May 2026 | Viewed by 7 | Submission Open

Keywords: tissue engineering; regenerative medicine; drug delivery; bioengineering; angiogenesis

(This special issue belongs to the Section Molecular Biology)

Nutrition of Crustaceans: A Molecular Perspective

edited by

Cheng Chi

submission deadline 25 May 2026 | Viewed by 97 | Submission Open

Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Research and Advancements in Neurodegenerative Diseases

edited by Meera Soundararajan

submission deadline 25 May 2026 | Viewed by 70 | Submission Open

Keywords: neurodegenerative disorders; neurons; Alzheimer’ s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington disease

(This special issue belongs to the Section Molecular Neurobiology)

DNA Damage and Repair Mechanisms in Cancer

edited by

Luigi Alfano

submission deadline 25 May 2026 | Viewed by 55 | Submission Open

Keywords: DNA damage response (DDR); genome instability ; synthethic lethality ; DNA repair

(This special issue belongs to the Section Molecular Oncology)

Cross-Kingdom Conversations: Deciphering Molecular Interactions in Microorganisms and Plants

edited by Eun-Hae Kwon

submission deadline 25 May 2026 | Viewed by 42 | Submission Open

Keywords: plant– microbe interactions; cross-kingdom signaling; plant growth-promoting microorganisms (PGPMs); molecular communication; synthetic microbial communities (SynComs)

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms in Mucosal Immunity

edited by

Mónica Vermeulen

submission deadline 25 May 2026 | Viewed by 9 | Submission Open

Keywords: mucosal immunity; metabolism; innate memory; trainers and inflammatory stimuli

(This special issue belongs to the Section Molecular Immunology)

Virus Detection and Analysis: Molecular Investigations

edited by

Hayes Kam-Hei Luk

submission deadline 26 May 2026 | Viewed by 89 | Submission Open

Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Strategies Targeting Cancer Stem Cells

edited by Luciano Vellón

submission deadline 28 May 2026 | Viewed by 73 | Submission Open

Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer

(This special issue belongs to the Section Molecular Oncology)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 30 May 2026 | 1 articles | Viewed by 4265 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Materials: Novel Studies and Related Applications

edited by

Iuliana Deleanu

submission deadline 30 May 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: antimicrobial materials; functional materials; composite materials; contamination; green materials; green technologies; metallic materials; drug resistance; environmental safety; biocompatibility; biodegradability

(This special issue belongs to the Section Materials Science)

Design, Synthesis, and Biological Evaluation of Novel Bioactive Compounds

edited by Monika Wujec and Oleg M. Demchuk

submission deadline 30 May 2026 | Viewed by 542 | Submission Open

Keywords: drug design; organic compounds; heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; structure– activity relationships (SARs); organic synthesis; natural product

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Evolution of the Vertebrate Immune System

edited by

Pierre Pontarotti

submission deadline 30 May 2026 | Viewed by 289 | Submission Open

Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias

edited by Yingjie Liu

submission deadline 30 May 2026 | Viewed by 232 | Submission Open

Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies

(This special issue belongs to the Section Molecular Biology)

Atomic-Scale Design of Li-Ion Battery Materials

edited by

Saiful Islam

submission deadline 30 May 2026 | Viewed by 87 | Submission Open

Keywords: lithium-ion batteries; atomic-scale design; electrode– electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries

(This special issue belongs to the Section Materials Science)

Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products

edited by Emira D’Amico

submission deadline 30 May 2026 | Viewed by 77 | Submission Open

Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals

(This special issue belongs to the Section Molecular Biology)

Nanostructured Strategies for Bioactive Compounds

edited by

Karen Khachatryan

submission deadline 30 May 2026 | Viewed by 68 | Submission Open

Keywords: nanostructure-bioactive interaction; molecular encapsulation mechanisms; metallic nanoparticles (bioactivity); carbon-based nanocarriers; nano/microcapsule delivery systems; bioactive compound stabilisation; structure-activity relationships; molecular release kinetics

(This special issue belongs to the Section Molecular Biology)

Oral Diseases and Oral Soft Tissue Repair

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 65 | Submission Open

Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytokines and Inflammatory Diseases

edited by

Pio Conti

submission deadline 30 May 2026 | Viewed by 57 | Submission Open

Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation

(This special issue belongs to the Section Molecular Immunology)

Hormetic Responses of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 30 May 2026 | Viewed by 38 | Submission Open

Keywords: hormesis; environmental stress; dose– response; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Extracellular Matrix Signalling in Health and Disease

edited by

Helen L. Birch

submission deadline 30 May 2026 | Viewed by 34 | Submission Open

Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Engineering Cell-Derived Nanostructures for Therapeutic Delivery

edited by

Tania Limongi

submission deadline 30 May 2026 | Viewed by 28 | Submission Open

Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions

edited by

Daniele La Russa

and

Daniela Pellegrino

submission deadline 30 May 2026 | Viewed by 28 | Submission Open

Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Cancer: From Molecular Mechanisms to Therapeutics

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 8 | Submission Open

Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology

(This special issue belongs to the Section Molecular Oncology)

Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition

edited by

Marianna Lauricella

and

Antonella D'Anneo

submission deadline 31 May 2026 | 4 articles | Viewed by 22689 | Submission Open

Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer

(This special issue belongs to the Section Molecular Pharmacology)

State-of-the-Art Molecular Oncology in Brazil, 3rd Edition

edited by