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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Synapse to Substance Use: Endocannabinoids and Cannabinoid Receptors in Brain Plasticity and Addiction Circuits

edited by Balapal S. Basavarajappa

submission deadline 31 Jan 2026 | Viewed by 119 | Submission Open

Keywords: anandamide; cannabis; alcohol; drug abuse; plasticity; neurotransmitters; cell-types; reward system

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights and Therapeutic Advances in Cerebral and Spinal Tumors

edited by

Alexandru Vladimir Ciurea

submission deadline 31 Jan 2026 | Viewed by 119 | Submission Open

Keywords: central nervous system tumors; molecular oncology; gliomas and spinal cord neoplasms; targeted therapy and precision medicine; neuro-oncology biomarkers; tumor microenvironment; immunotherapy; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Peripheral Nerve Regeneration—2nd Edition

edited by

Cinzia Fabrizi

submission deadline 31 Jan 2026 | Viewed by 119 | Submission Open

Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth

(This special issue belongs to the Section Molecular Neurobiology)

Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action

edited by Likun Gong,

Qiuping Qin

and Jing Chen

submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open

Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in the Pathophysiology and Therapy of Cerebral Gliomas

edited by

Placido Bruzzaniti

submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open

Keywords: mutant IDH1 3; EVs; Ki67; HSV1-TK; glioma; lipid vesicles; viral vectors; ATRX; EGFR; IDH1; MGMT; 1p/19q codeletion

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Supramolecular Structure

edited by Massoud Kaykhaii

submission deadline 31 Jan 2026 | Viewed by 117 | Submission Open

Keywords: supramolecular chemistry; molecular self-assembly; host– guest interactions; molecular recognition; non-covalent interactions; dynamic supramolecular systems; stimulus-responsive materials; nanostructures; supramolecular therapeutics; structural characterization

(This special issue belongs to the Section Materials Science)

The Medicinal Value of Plant Extracts

edited by

Myrna Déciga-Campos

and

Rosa Ventura-Martínez

submission deadline 31 Jan 2026 | Viewed by 116 | Submission Open

Keywords: medicinal plant; essential oil; cancer; diabetes; pain; inflammation; neurodegenerative diseases; metabolites; bioactive compounds; toxicity; safety; mutagenicity; genotoxicity; biological evaluations; efficacy; molecular

(This special issue belongs to the Section Molecular Pharmacology)

Systems Approaches to Diabetic Complications

edited by

Paola Pontrelli

submission deadline 31 Jan 2026 | Viewed by 116 | Submission Open

Keywords: diabetes; diabetic complications; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

New Insights into Natural Products with Antimicrobial Activities

edited by Jose Javier Sanz Gomez

submission deadline 31 Jan 2026 | Viewed by 115 | Submission Open

Keywords: bioactive compounds; biotechnological substances; essential oils; plant extracts; mechanism of action; interactions; biofilms; active packaging; technological processes; safety

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Strategies in Bacterial Antibiotic Resistance

edited by Xuemei Yang

submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open

Keywords: antibiotic resistance; resistance mechanisms; antibiotic resistance genes (ARGs); antibiotic tolerance; heteroresistance; horizontal gene transfer (HGT); compensatory evolution

(This special issue belongs to the Section Molecular Microbiology)

Current Research on Structure and Functions of Ribosomal Proteins

edited by

Youri Timsit

submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open

Keywords: protein synthesis; translation; translocation; dynamics; folding; network; assembly; evolution

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Related to Exercise

edited by Giorgia Scarfò

submission deadline 31 Jan 2026 | Viewed by 112 | Submission Open

Keywords: exercise; mitochondrial biogenesis; intracellular pathways; inflammation; oxidative stress; hypertrophy; metabolism angiogenesis

(This special issue belongs to the Section Molecular Biology)

Emerging Technologies in Musculoskeletal Research: From Molecular Mechanisms to Translational Innovation

edited by

Javad Tavakoli

submission deadline 31 Jan 2026 | Viewed by 112 | Submission Open

Keywords: musculoskeletal tissue; cell mechanobiology; biofabrication; tissue regeneration; organ-on-a-chip; disease mechanism and screening; molecular and cellular diagnostics; AI and machine learning; omics technology; wearable technologies; implant technologies; biomarkers; predictive modelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Retinal Diseases: 2nd Edition

edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo

submission deadline 31 Jan 2026 | Viewed by 112 | Submission Open

Keywords: faricimab; modified cerebrolysin; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Cellular and Molecular Mechanisms of Central Nervous System Injury

edited by

Laurent R. Gauthier

and

José R. Pineda

submission deadline 31 Jan 2026 | Viewed by 111 | Submission Open

Keywords: central nervous system damage; CNS; oxidative stress; DNA damage responses; neuroregeneration; blood– brain barrier disruption

(This special issue belongs to the Section Molecular Neurobiology)

Host–Oral Bacterial Interaction in Periodontal Pathogenesis

edited by Felice Roberto Grassi

submission deadline 31 Jan 2026 | Viewed by 111 | Submission Open

Keywords: periodontitis; oral microbiome; host– pathogen interaction; inflammation; dysbiosis; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Engineered Mesenchymal Stromal/Stem Cells: Increasing Targeting Precision in Cancer Therapy

edited by

Urban Švajger

submission deadline 31 Jan 2026 | Viewed by 111 | Submission Open

Keywords: engineered mesenchymal stromal stem cells; targeted cancer therapy; tumor microenvironment; cell-based drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stress-Related Disorders and Depression: From Molecular Basis to Therapy (3rd Edition)

edited by

Irena Nalepa

and

Agnieszka Zelek-Molik

submission deadline 31 Jan 2026 | Viewed by 111 | Submission Open

Keywords: psychobiology of stress; depression; posttraumatic stress disorder; anxiety disorders; animal models; biogenic monoamines; glucocorticoids; inflammation; antidepressant and anxiolytic drugs

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Retinal Degeneration

edited by Sayan Ghosh

submission deadline 31 Jan 2026 | Viewed by 110 | Submission Open

Keywords: retinal degeneration; photoreceptors; retinal pigmented epithellium (RPE) cells; retinal ganglion cells; glial cells; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular Insights into Animal Nutrition

edited by

Bin Feng

submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open

Keywords: reproduction; animal production; development; immunity; emissions; digestion efficiency; microbiome; metabolism; molecular signaling; nutritional strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Progress in Peptide Drugs

edited by

Mariana S. Castro

submission deadline 31 Jan 2026 | Viewed by 107 | Submission Open

Keywords: novel therapeutic peptides; peptide design; antimicrobial; anticancer; drug delivery systems; peptidomimetics

(This special issue belongs to the Section Molecular Pharmacology)

Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 31 Jan 2026 | Viewed by 107 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery

(This special issue belongs to the Section Molecular Oncology)

From Biology to Biomechanics: Molecular Advances in Orthodontic Remodeling and Acceleration

edited by

Marcin Derwich

and

Alessandra Lucchese

submission deadline 31 Jan 2026 | Viewed by 107 | Submission Open

Keywords: orthodontic tooth movement; bone remodeling; root resorption; molecular mechanisms; inflammatory response; corticotomy-assisted orthodontics; biomechanics; periodontal ligament; cellular signaling; accelerated orthodontic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Strategies in Tuberculosis Drug Discovery

edited by

Parvesh Singh

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: anti-tuberculosis agents; MDR-TB; XDR-TB; drug repurposing; hybrid drugs; high-throughput screening; structure-based drug design; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Cardiac Repairs and Regeneration

edited by William C.W. Chen

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: cardiac regeneration; cardioprotection; molecular cardiology; regenerative signaling pathways; metabolic reprogramming; protein quality control; post‑translational modifications; single‑cell and spatial omics; multi-omics; CRISPR‑based genome and epigenome editing; high‑resolution molecular imaging; synthetic and systems biology; artificial intelligence and machine learning

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tau Pathology Mechanisms and Therapeutic Interventions

edited by

Claudia Marino

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: tau; misfolding; neurodegeneration; Alzheimer’ s disease; oligomer; tauopathies; therapies; hyperphorphorylation; frontotemporal lobe dementia; synapses; spreading

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNAs as Biomarkers in Chronic Diseases

edited by

Xiao Wang

submission deadline 31 Jan 2026 | Viewed by 103 | Submission Open

Keywords: microRNA; biomarker; chronic diseases; cancer; cardiovascular diseases; psychiatric conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Symbiosis and Molecular Mechanisms in Water Treatment

edited by

Binghan Xie

submission deadline 31 Jan 2026 | Viewed by 101 | Submission Open

Keywords: microbiomics; water treatment; bioenergy recovery; emerging contaminant degradation; antibiotic resistance genes (ARGs); microalgae biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Characterization of Immune and Inflammatory Tumor Microenvironment on Canine, Feline and Human Species

edited by

Luís Monteiro

submission deadline 31 Jan 2026 | Viewed by 101 | Submission Open

Keywords: inflammation; tumor microenvironment; cancer biomarkers; comparative pathology; cancer epidemiology; cancer risk factors; molecular diagnostics; proteomics; treatment response; targeted therapy; immunotherapy; translation cancer research

(This special issue belongs to the Section Molecular Oncology)

Molecular Genetics, Epigenetics and Genomics of Neurodegenerative Diseases

edited by

Simone Agostini

submission deadline 31 Jan 2026 | Viewed by 101 | Submission Open

Keywords: epigenetics; microRNA; genetics; genomics; methylation; histone modification; neurodegenerative diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pulmonary Hypertension: From Molecular Pathophysiology to New Therapeutic Approaches

edited by Claudia Mickael

submission deadline 31 Jan 2026 | Viewed by 100 | Submission Open

Keywords: pulmonary hypertension; molecular pathophysiology; vascular remodelling; targeted therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms in Postharvest Biology

edited by

Kangdi Hu

submission deadline 31 Jan 2026 | Viewed by 99 | Submission Open

Keywords: postharvest biology; fruit ripening; senescence; stress tolerance; disease resistance; molecular biology; gene regulatory networks; genomics; synthetic biology; nanotechnology; controlled atmosphere; biostimulants

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathways and Pathogenesis in Orthopedic Diseases

edited by

Angelos Kaspiris

and

Elias Vasiliadis

submission deadline 31 Jan 2026 | Viewed by 99 | Submission Open

Keywords: intracellular interactions during fracture healing; molecular signaling of degenerative orthopedic diseases; growth factor expression in musculoskeletal disorders and deformities; pathophysiology of primary bone tumors and metastasis; clinical and molecular basis of orthopedic infections; biomarkers; molecular-driven treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Tumor Microenvironment of Pleural Mesothelioma and Opportunities for Novel Treatments

edited by

Marcella Barbarino

submission deadline 31 Jan 2026 | Viewed by 98 | Submission Open

Keywords: mesothelioma; tumor-associated stromal cells; immunotherapy; tumor microenvironment; cancer-associated fibroblast; mesenchymal stem cells; endothelial cells; cancer-associated adipocytes

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Aquatic Animal Reproduction, Breeding Strategies and Genetic Improvement

edited by

Jixing Zou

submission deadline 31 Jan 2026 | Viewed by 97 | Submission Open

Keywords: reproductive biology; aquaculture genetics; fish breeding; genomic selection; marker-assisted selection; genome editing; hybridization; genetic improvement; molecular breeding; sustainable animal production

(This special issue belongs to the Section Molecular Biology)

Effects of Natural Products on Neurological Diseases

edited by

Maytal Shabat-Simon

submission deadline 31 Jan 2026 | Viewed by 95 | Submission Open

Keywords: natural products; neurodegenerative diseases; oxidative stress; neuroinflammation; amyloid β ; TAU pathology; PI3K/AKT; BDNF-TrkB-CREB; phytochemicals; neuroprotection; cannabinoids; psilocybin/psilocyn; mitochondrial dysfunction; blood– brain barrier; high-throughput screening; animal models; structure– activity relationship; pharmacokinetics; bioavailability

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Regulation of Glycoproteins in Cancer Biology

edited by

Josiah Ochieng

submission deadline 31 Jan 2026 | Viewed by 94 | Submission Open

Keywords: glycoprotein; metastasis; glycosylation; tumor progression

(This special issue belongs to the Section Molecular Biology)

Advanced Research on Immune Cells and Cytokines (3rd Edition)

edited by

Athanasia Mouzaki

submission deadline 31 Jan 2026 | Viewed by 93 | Submission Open

Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system

(This special issue belongs to the Section Molecular Immunology)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Jan 2026 | Viewed by 92 | Submission Open

Keywords: placental barrier; maternal– fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Obesity and Obesity-Associated Co-Morbidities: From Mechanisms to Mechanism-Based Therapies

edited by

Dario C. Ramirez

submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open

Keywords: obesity; adipose tissue inflammation; microbiota; oxidative stress; gene expression regulation; metabolism; obesity-associated co-morbidities; non-communicable disease; cancer; mechanism-based therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

Intracellular Host-Bacteria Dynamics: Unraveling the Molecular Basis

edited by

Apichai Tuanyok

submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open

Keywords: intracellular bacteria; granuloma; immune invasion; Mycobacterium tuberculosis; Burkholderia pseudomallei; Francisella; Brucella; Listeria; Coxiella

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in Striated Muscle Physiology

edited by Xuesong Feng

submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open

Keywords: striated muscle; physiology; myopathies; mitochondria; mechanotransduction; epigenetics regulation; muscle aging; muscle regeneration

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Fibrous Proteins: Latest Developments in Molecular Study

edited by Priscila Casado

submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open

Keywords: fibrous proteins; molecular studies; translational applications; inflammatory markers; biomolecular expression; immunological pathways; personalized treatments; diagnostics; clinical practice; etiopathogenies

(This special issue belongs to the Section Molecular Biology)

Molecular Pharmacognosy: Bioactive Natural Products and Mechanistic Insights

edited by Luísa Mota Da Silva

submission deadline 31 Jan 2026 | Viewed by 89 | Submission Open

Keywords: pharmacognosy; natural products; bioactive compounds; phytochemistry; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Mechanisms of Action of Environmental Neurotoxicants During Critical Periods of Brain Development

edited by

Yael Abreu-Villaça

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: environmental neurotoxicants; developmental neurotoxicity; critical windows; animal models; early exposure; long-term programming

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Food Science: From Nutritional Value to Safety Evaluation

edited by

Mariachiara Bianco

submission deadline 31 Jan 2026 | Viewed by 87 | Submission Open

Keywords: nutraceutical; food safety; analytical methods; novel foods; food analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Therapeutic Advances in Vaccines

edited by Dorota Kopciuch

submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open

Keywords: therapeutic vaccines; mRNA vaccines; DNA-based vaccines; viral vector vaccines; protein-based vaccines; peptide vaccines; personalized cancer vaccines; antigen persistence; immune activation mechanisms

(This special issue belongs to the Section Molecular Immunology)

Unraveling Affective Disorders: From Pathogenesis to Drug Therapy

edited by Lawrence Shih-Hsin Wu

submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open

Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene– environment interactions; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure– activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 1251-1300 on page 26 of 66.

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