Molecular Genetics, Epigenetics and Genomics of Neurodegenerative Diseases

Dear Colleagues, 

Understanding complex neurodegenerative diseases requires integrating genetics, epigenetics, and genomics. Genetics studies inherited DNA variations affecting disease risk, while epigenetics examines reversible modifications like DNA methylation, histone changes, and miRNA expression that regulate gene activity without altering DNA sequences. Genomics analyzes the entire genome and its regulatory elements, combining genetic and epigenetic data to reveal molecular mechanisms behind disease.

In disorders such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis, genetics identifies risk variants; however, gene–environment interactions and epigenetic changes are also crucial. Epigenetic alterations affect cellular functions and respond to environmental factors, aging, and disease progression. Advanced genomic technologies enable researchers to uncover complex molecular signatures, offering insights into disease heterogeneity and potential biomarkers.

For these reasons, this Special Issue welcomes research and reviews focusing on the molecular mechanisms underlying neurodegenerative diseases, including the following:

1. Genetic variants;
2. DNA methylation;
3. Histone modifications;
4. miRNA expression;
5. Genomic regulation.

Experimental studies, whether in vitro or disease-controlled, will contribute to a deeper understanding of disease biology and open new avenues for pharmacological and clinical therapies.

Dr. Simone Agostini
Guest Editor

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