Molecular Mechanisms and Regulation of Glycoproteins in Cancer Biology

Dear Colleagues,

Glycoproteins play a crucial role in cancer development and progression by influencing various cellular processes such as cell signaling, adhesion, immune evasion, exosomal secretion and uptake, and metastasis. Aberrant glycosylation of proteins—a common feature in many tumors—can alter the structure and function of glycoproteins, leading to enhanced tumor growth and invasiveness. For instance, changes in the glycosylation patterns of cell surface glycoproteins such as mucins and integrins can promote detachment from the primary tumor, facilitate migration, and aid the colonization of distant tissues. Additionally, tumor-associated glycoproteins can modulate immune recognition, enabling cancer cells to escape immune surveillance. Because of their distinct expression patterns, glycoproteins are being explored as biomarkers for early cancer detection and as targets for novel therapeutic interventions. More importantly, we are just beginning to understand the intricate ‘glyco-codes’ read by the ever-expanding tumor-associated lectins that could define the next generation of cancer therapy. The goal of this Special Issue is to highlight the mechanisms that drive tumor progression driven by glycoproteins, as well as how they can be harnessed to improve cancer therapy.

Prof. Dr. Josiah Ochieng
Guest Editor

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