Molecular Pathways and Pathogenesis in Orthopedic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 7
Special Issue Editors
Interests: orthopedic diseases; pathophysiology of osteoarthritis; biomarkers and pathological background of non-union fractures; mechanisms of fractures’ union and bone regeneration; bone metabolism basis; pathophysiology and molecular basis of spinal deformities; orthopedic infections
Special Issues, Collections and Topics in MDPI journals
Interests: orthopedic diseases; pathophysiology of intervertebral disk degeneration; spinal deformities and spinal cord injuries; mechanisms of aseptic loosening after total arthroplasty; periprosthetic infections after total arthroplasty; biomechanics of shoulder arthroplasty
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The research breakthroughs in the intracellular signaling events focusing on the development of degenerative and traumatological orthopedic diseases during the last decade have provided the scientific community with significant tools for the understanding and management of musculoskeletal disorders.
Moreover, investigations into the role of several molecules such as cytokines, chemokines, growth factors, protein receptors and hormones in the intracellular signal transduction cascades have unveiled new possible targets for the prevention and treatment of orthopedic diseases.
However, the complex molecular processes that take place in maintaining the bone micro-environmental architecture and homeostasis remains largely unclear.
The aim of this Special Issue is not only to summarize the current knowledge and underlying mechanisms of the pathophysiology of orthopedic diseases, but also to reveal the recent advancements at the pre-clinical and clinical field that my result in potential new treatment approaches.
Original research and review articles will be considered if they have a clear added value into the available body of literature in this Special Issue in IJMS.
The thematic scope of the articles should comprise the clinical, diagnostic and therapeutic aspects of these disorders in the context of their molecular background.
Topics of interest include, but are not limited to:
- In vitro experimental discoveries that are linked to the molecular signaling of orthopedic diseases
- In vivo findings exploring the functional role of intracellular molecules
- Expression of cytokines or growth factors that may be applied as biomarkers in clinical practice
- Studies correlating clinical results with possible underlying pathological pathways
- Potential target therapies for the management of musculoskeletal disorders
- Metabolic basis of bone diseases
We are looking forward to receiving your contributions.
Dr. Angelos Kaspiris
Dr. Elias Vasiliadis
Guest Editors
Manuscript Submission Information
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Keywords
- intracellular interactions during fracture healing
- molecular signaling of degenerative orthopedic diseases
- growth factor expression in musculoskeletal disorders and deformities
- pathophysiology of primary bone tumors and metastasis
- clinical and molecular basis of orthopedic infections
- biomarkers
- molecular-driven treatment
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