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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Trends in Organometallic Chemistry and Its Applications

edited by

Senka Djaković

and Jasmina Lapić

submission deadline 31 Mar 2027 | 1 articles | Viewed by 606 | Submission Open

Keywords: (bio)organometallic chemistry; synthesis; application; structure–property relationships; computational modelling; ligand design; biomedical materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Single Cell Transcriptomics in Human Disease

edited by

Md. Mahmudul Hasan

submission deadline 31 Mar 2027 | 1 articles | Viewed by 600 | Submission Open

Keywords: single-cell RNA sequencing; brain aging; neurodegeneration; cellular heterogeneity; transcriptomics; neuronal aging; glial cells; senescence; cognitive decline; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Research Progress in Food Packaging Materials

edited by

Anouar Mouhoub

submission deadline 31 Mar 2027 | 1 articles | Viewed by 598 | Submission Open

Keywords: molecular design; intermolecular interactions; structure–property relationships; bio-based polymers; controlled release systems; active packaging; sustainable materials

(This special issue belongs to the Section Materials Science)

Kidney Transplantation: Current Framework and New Perspectives

edited by Alberto Rosati

submission deadline 31 Mar 2027 | 1 articles | Viewed by 563 | Submission Open

Keywords: renal transplantation; organ donation; living donation; transplant survival; organ preservation; healthcare costs; acute and chronic rejection; immune tolerance; xenotransplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Antimicrobial Resistance in Cancers

edited by Nicola Silvestris and Massimo Andreoni

submission deadline 31 Mar 2027 | Viewed by 562 | Submission Open

Keywords: antimicrobial resistance; host–pathogen interaction; immune dysfunction; immunosuppression; infection; biomarker; novel antimicrobials; cancer; frail patient

(This special issue belongs to the Section Molecular Oncology)

Molecular and Nanoscience Approaches to Neurodevelopmental Disorders

edited by

Khairunnuur Fairuz Azman

submission deadline 31 Mar 2027 | Viewed by 533 | Submission Open

Keywords: neurodevelopment; molecular neuroscience; neurotrophic signaling; epigenetics; synaptic plasticity; neuroinflammation; neurodevelopmental disorders; biomarkers; nanoneuroscience; nanotechnology

(This special issue belongs to the Section Molecular Neurobiology)

Antibiotic Resistance: Recent Developments and Future Prospects

edited by

Awais Ghaffar

submission deadline 31 Mar 2027 | 1 articles | Viewed by 531 | Submission Open

Keywords: antimicrobial resistance detection; microbial ecology; shotgun metagenomics; genome-resolved metagenomics; microbiome analysis; resistome characterization; One Health

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Strategies for Melanoma Immunotherapy

edited by

Andrzej Mackiewicz

and

Piotr Rutkowski

submission deadline 31 Mar 2027 | Viewed by 523 | Submission Open

Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 31 Mar 2027 | Viewed by 519 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Pharmacological Targets and Therapeutic Strategies in Diabetes and Obesity

edited by

Roma Patel

submission deadline 31 Mar 2027 | 1 articles | Viewed by 498 | Submission Open

Keywords: diabetes; obesity; molecular pharmacology; therapeutic targets; insulin resistance; β-cell dysfunction; metabolic signaling pathways; adipose tissue biology; drug–target interactions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Calcium Dynamics in Disease: Mechanisms and Therapeutic Opportunities

edited by

Valeria Magnelli

submission deadline 31 Mar 2027 | Viewed by 495 | Submission Open

Keywords: calcium signaling; homeostasis; deregulation; calcium imbalance

(This special issue belongs to the Section Biochemistry)

Depression: From Molecular Basis to Therapy—3rd Edition

edited by

Terezia Kiskova-Simkova

submission deadline 31 Mar 2027 | Viewed by 492 | Submission Open

Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers

(This special issue belongs to the Section Molecular Neurobiology)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 31 Mar 2027 | Viewed by 486 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathogenesis and Treatments of Pediatric Leukemias

edited by

Joanna Zawitkowska

submission deadline 31 Mar 2027 | Viewed by 477 | Submission Open

Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenic Escherichia coli: Cellular Biology, Mechanisms of Pathogenesis, Therapeutic Approaches and Strategies for Disease Intervention

edited by

Jorge Goldstein

submission deadline 31 Mar 2027 | Viewed by 475 | Submission Open

Keywords: enterohemorrhagic E. coli; EHEC; Shiga toxin-producing E. coli; STEC; HUS; inflammation; kidney; blood; brain; pathogenesis; antibodies; extraintestinal pathogenic E. coli; E. coli pathotypes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Role of Heterogeneous Catalysis in Materials Science and Application

edited by Alejandro Pérez Larios and

Carlos Soto Robles

submission deadline 31 Mar 2027 | 1 articles | Viewed by 469 | Submission Open

Keywords: heterogeneous photocatalysis; photocatalytic materials; structure–property relationships; catalyst design; surface and interface engineering; operando characterization; charge transfer dynamics; sustainable photocatalysis; CO2 photoconversion; environmental photocatalysis

(This special issue belongs to the Section Materials Science)

Unraveling the Host–Virus Interplay in Viral Infection: Molecular Mechanisms and Therapeutic Horizons

edited by

Agustín Valenzuela-Fernández

and

Romina Cabrera-Rodríguez

submission deadline 31 Mar 2027 | Viewed by 466 | Submission Open

Keywords: host–virus interplay; viral infection; molecular mechanisms; antiviral defenses; molecular tools for diagnosis and therapies

(This special issue belongs to the Section Molecular Biology)

DNA Damage and DNA Repair in Health and Diseases

edited by Silvina B. Nadin

submission deadline 31 Mar 2027 | Viewed by 465 | Submission Open

Keywords: genome instability; DNA damage response; DNA repair mechanisms; cancer; therapeutic targets; preclinical studies; translational studies; DNA repair and immune system; PARP inhibitors; BRCA1/2

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Combinatorial Strategies in Anti-Obesity Therapeutics

edited by

James Ernest Blevins

submission deadline 31 Mar 2027 | Viewed by 456 | Submission Open

Keywords: obesity; high-fat diet; rodents; pharmacotherapy; body weight; food intake

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dermatological Perspectives on Connective Tissue Diseases

edited by

Yoshihide Asano

submission deadline 31 Mar 2027 | Viewed by 450 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjögren’s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 31 Mar 2027 | Viewed by 448 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

The Role of miRNAs in Healthy Lungs and Chronic Lung Diseases

edited by Victor Ruiz

submission deadline 31 Mar 2027 | Viewed by 447 | Submission Open

Keywords: miRNA; DROSHA; DICER; DGCR8; ADAR; pulmonary fibrosis; COPD; asthma; lung neoplasm

(This special issue belongs to the Section Molecular Biology)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 31 Mar 2027 | Viewed by 433 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Molecular Insights into Alzheimer's Disease

edited by

Giulia Sita

submission deadline 31 Mar 2027 | Viewed by 433 | Submission Open

Keywords: neurodegeneration; neuroprotection; pharmacology; toxicology; Alzheimer’s disease; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology of Placental Function and Pregnancy Complications

edited by

Yoshinori Moriyama

submission deadline 31 Mar 2027 | Viewed by 430 | Submission Open

Keywords: placenta; placental dysfunction; pregnancy complications; preeclampsia; fetal growth restriction; placental immunology

(This special issue belongs to the Section Molecular Biology)

Current Research on the Structural Biology of Membrane Proteins

edited by

Izuru Kawamura

submission deadline 31 Mar 2027 | Viewed by 429 | Submission Open

Keywords: NMR; X-ray diffraction; cryo-electron microscopy; membrane protein; structure; dynamics; molecular dynamics simulation; vibrational spectroscopy

(This special issue belongs to the Section Molecular Biophysics)

Advances in Neuropharmacology in Neurodegenerative Disorders

edited by

Ichiro Kawahata

submission deadline 31 Mar 2027 | Viewed by 428 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Iron Metabolism in Health and Disease

edited by

Dariusz Szukiewicz

submission deadline 31 Mar 2027 | Viewed by 420 | Submission Open

Keywords: iron metabolism; iron homeostasis; hepcidin; anemia; iron overload

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Approaches to Aquatic Animal Health: Immunobiology, Infectious Diseases, Antimicrobial Resistance and One Health

edited by

Partho Debnath

submission deadline 31 Mar 2027 | 1 articles | Viewed by 407 | Submission Open

Keywords: aquatic animal health; molecular immunology; infectious diseases; antimicrobial resistance; One Health; whole-genome sequencing; host–pathogen interactions; comparative genomics; molecular diagnostics; molecular epidemiology

(This special issue belongs to the Section Molecular Immunology)

The Medicinal Value of Plant Extracts

edited by

Myrna Déciga-Campos

and

Rosa Ventura-Martínez

submission deadline 31 Mar 2027 | Viewed by 404 | Submission Open

Keywords: medicinal plant; essential oil; cancer; diabetes; pain; inflammation; neurodegenerative diseases; metabolites; bioactive compounds; toxicity; safety; mutagenicity; genotoxicity; biological evaluations; efficacy; molecular

(This special issue belongs to the Section Molecular Pharmacology)

Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges

edited by

Alessandra Micera

and

Filippo Biamonte

submission deadline 31 Mar 2027 | Viewed by 404 | Submission Open

Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence

(This special issue belongs to the Section Molecular Neurobiology)

Virus Detection and Analysis: Molecular Investigations

edited by

Hayes Kam-Hei Luk

submission deadline 31 Mar 2027 | Viewed by 403 | Submission Open

Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing

(This special issue belongs to the Section Molecular Microbiology)

Plant-Based Early Therapeutics for Parasitic Infections Combined with Functional Modern Diagnosis Methods

edited by

Lee Tian Chang

submission deadline 31 Mar 2027 | Viewed by 389 | Submission Open

Keywords: active phytocompounds; antiparasitic agents; artificial intelligence; early diagnosis early treatment; life cycle; medicinal plants; parasite and vector; phytogenic feed additives; vision recognition

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 31 Mar 2027 | Viewed by 384 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Updates on Oral Potentially Malignant Disorders: From Pathogenesis to Treatment

edited by

Takahiro Abe

submission deadline 31 Mar 2027 | Viewed by 379 | Submission Open

Keywords: oral potentially malignant disorders; oral leukoplakia; oral erythroplakia; oral lichen planus/oral lichenoid lesions; oral submucous fibrosis; oral epithelial dysplasia; malignant transformation risk; biomarkers; imaging/diagnostic support; genomic or epigenomic factor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 31 Mar 2027 | Viewed by 372 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure–activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 31 Mar 2027 | Viewed by 370 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 31 Mar 2027 | Viewed by 366 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research on Snake Venoms

edited by

Isadora Sousa De Oliveira

and

Eliane Candiani Arantes

submission deadline 31 Mar 2027 | Viewed by 365 | Submission Open

Keywords: snake venoms; venomics; toxin diversity; toxin evolution; structure–function relationships; bioactive peptides; antivenom development; recombinant toxins; molecular mechanisms of toxicity

(This special issue belongs to the Section Molecular Biology)

Immune Responses as the Central Determinant of Gene Therapy Outcomes

edited by

Manoj Pandey

submission deadline 31 Mar 2027 | Viewed by 363 | Submission Open

Keywords: innate and adaptive immune sensing; TLR signaling; complement activation; antigen presentation; T‑cell cytotoxicity; humoral immunity (IgG, IgM, IgA); pediatric immunology; rare disease; lysosomal storage disease; neuroinflammation; immunomodulatory therapies; complement inhibitors

(This special issue belongs to the Section Molecular Immunology)

miRNA in Physiology and Pathophysiology

edited by

Ivan Jovanović

submission deadline 31 Mar 2027 | Viewed by 361 | Submission Open

Keywords: microRNAs; gene regulation; physiology; pathophysiology; biomarkers; complex diseases; cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Advances in Infection Immunology

edited by

Arturo Contis-Montes De Oca

submission deadline 31 Mar 2027 | Viewed by 353 | Submission Open

Keywords: neuro-infection; innate immunity; immunopathology; microbiome-immune axis; chronic in-flammation

(This special issue belongs to the Section Molecular Immunology)

Endometriosis: Contemporary Insights and Emerging Perspectives

edited by

Márcia Mendonça Carneiro

submission deadline 31 Mar 2027 | Viewed by 349 | Submission Open

Keywords: endometrisis; infertility; chronic pelvic pain

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Novel Therapeutic Strategies Targeting Cancer Stem Cells

edited by Luciano Vellón

submission deadline 31 Mar 2027 | Viewed by 343 | Submission Open

Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer

(This special issue belongs to the Section Molecular Oncology)

Advances in Infectious Disease Detection: Novel Assays and Biomarkers

edited by

Leonardo M. Leony

submission deadline 31 Mar 2027 | Viewed by 342 | Submission Open

Keywords: in vitro diagnostics (IVD); imunoassays; nucleic acid testing; serology; point-of-care testing (PoCT)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advancements in Cancer Immunotherapy

edited by

Pritam Sadhukhan

submission deadline 31 Mar 2027 | Viewed by 341 | Submission Open

Keywords: immune checkpoint inhibitor; PD-1 inhibitor; PDL-1 inhibitor; CTLA-4 inhibitor; B7H3 inhibitors; CAR-T cell therapy; nanotechnology in immunotherapy; tumor microenvironment remodeling

(This special issue belongs to the Section Molecular Oncology)

Small Molecules and Antibodies for Targeted Cancer Therapies

edited by Chitra Subramanian

submission deadline 31 Mar 2027 | Viewed by 340 | Submission Open

Keywords: targeted therapy; small molecules; antibodies; drug resistance; metastasis; cancer treatment; mechanism of resistance

(This special issue belongs to the Section Molecular Pharmacology)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 31 Mar 2027 | Viewed by 338 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

Computational Models in Oncology: From Tumor Initiation to Progression to Treatment

edited by

Vladimir Simic

submission deadline 31 Mar 2027 | Viewed by 330 | Submission Open

Keywords: computational models; tumor growth; computational oncology; multiscale modeling; cancer progression; treatment response modeling; mathematical modeling

(This special issue belongs to the Section Molecular Informatics)

Genetic-Driven Precision Oncology in Prostate Cancer

edited by

Pierre Tennstedt

submission deadline 31 Mar 2027 | Viewed by 320 | Submission Open

Keywords: prostate cancer; genetic; biomarker; liquid biopsy; urine; blood; tissue; treatment strategies; diagnosis; progression; metastasis; survival; hormone-sensitive; hormone-resistant; androgen deprivation therapy

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2801-2850 on page 57 of 62.

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