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Current Trends in Organometallic Chemistry and Its Applications

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Guest Editor
Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Interests: (bio)organometallic chemistry; organic synthesis; spectral analysis; chemistry of natural compounds

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Guest Editor Assistant
Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Interests: chemical synthesis; bioorganometallic chemistry; characterization of compounds; natural compounds

Special Issue Information

Dear Colleagues,

Organometallic chemistry has undergone significant development in recent years, driven by advances in synthetic methodologies, ligand design, the development of sustainable synthetic strategies and an improved understanding of the electronic and structural properties of the metal–carbon bond. Recent research has focused particularly on designing more efficient and selective transition metal-based catalysts, with an emphasis on sustainable and environmentally friendly processes. The development of advanced spectroscopic techniques and computational modelling has enabled more detailed studies of the reactivity, reaction mechanisms and stability of these compounds. As a result, these compounds have found wide application in organic synthesis, industrial catalysis, the development of functional materials and pharmaceutical chemistry. A particularly rapidly growing area is bioorganometallic chemistry, where organometallic complexes are investigated as anticancer and antimicrobial agents, diagnostic systems and platforms for targeted drug delivery. These achievements confirm the central role of organometallic chemistry in the development of modern, interdisciplinary and sustainable chemistry.

Prof. Dr. Senka Djaković
Guest Editor

Dr. Jasmina Lapić
Guest Editor Assistant

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Keywords

  • (bio)organometallic chemistry
  • synthesis
  • application
  • structure–property relationships
  • computational modelling
  • ligand design
  • biomedical materials

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Published Papers (1 paper)

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14 pages, 6876 KB  
Article
Structural Insights into the Photoactivatable CO Release from Mn-CO and Re-CO Complexes for CO Delivery
by Tao Wu, Chaoyang Shi, Chenyang Liu, Chenjie Qin, Jiangshan Wang, Yating Pang, Wenjun Gong, Wenming Wang and Hongfei Wang
Int. J. Mol. Sci. 2026, 27(15), 6704; https://doi.org/10.3390/ijms27156704 - 27 Jul 2026
Viewed by 404
Abstract
Two tri-carbonyl complexes, [Mn(CO)3(5cpa)Br] (1) and [Re(CO)3(5cqn)(OCH3)] (2), were synthesized, where 5cpa is 5-Cl-2-picolinic acid and 5cqn is 5-Cl-8-Hydroxyquinoline. Their structures were determined using X-ray diffraction techniques. The electronic absorption and IR spectra [...] Read more.
Two tri-carbonyl complexes, [Mn(CO)3(5cpa)Br] (1) and [Re(CO)3(5cqn)(OCH3)] (2), were synthesized, where 5cpa is 5-Cl-2-picolinic acid and 5cqn is 5-Cl-8-Hydroxyquinoline. Their structures were determined using X-ray diffraction techniques. The electronic absorption and IR spectra of the complexes were experimentally measured and theoretically assigned through density functional theory (DFT) calculations. The photo-induced CO release was verified using time-resolved infrared spectroscopy, and the transfer of CO to hemoglobin (Hb) was monitored by UV-vis spectroscopy. The rate of CO release and transfer from Mn complex 1 is significantly faster than that from Re complex 2. Complex 2 exhibits higher cytotoxicity against HeLa cells than complex 1, with IC50 values of 40.1 μM and 10.6 μM for 1 and 2, respectively, which decrease to 16.2 μM and 4.9 μM after photo irradiation. Moreover, 1 exhibited a stronger binding constant (Kb) with human serum albumin (HSA) than 2, with values of 1.6 × 106 and 7.0 × 105 M−1, respectively. The structures of HSA complex adducts revealed that both the resulting [Mn(CO)3(5cpa)] and [Re(CO)3(5cqn)] group coordinate with the N atom of His146, while four additional dissociated Mn-CO groups were observed to bind to HSA for complex 1. This study provides insights into the stability, possible metabolic pathways, and potential applications of these carbonyl complexes. Full article
(This article belongs to the Special Issue Current Trends in Organometallic Chemistry and Its Applications)
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