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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microbial Enzymes: Molecular Structure and Mechanism
edited by Rui Ma
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1070 | Submission Open
Keywords: microbial enzymes; biocatalytic application; molecular enzymology
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Neuropsychiatric Disorders
edited by Marina Mitrovic, and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1040 | Submission Open
Keywords: neurological disorders; psychiatric disorders; pathophysiological mechanisms; apoptosis; oxidative stress; inflammation; neurotransmitters; neurotrophins; pharmacotherapy; transcranial stimulation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Pharmacology and Biological Activities of Natural and Derivatives Bioactive Compounds submission deadline 30 Nov 2026 | 1 articles | Viewed by 1036 | Submission Open
Keywords: molecular pharmacology; therapeutic potential; natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; anticancer; antimicrobial; pharmacokinetics; pharmacodynamics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Regulation of Plant Tolerance to Saline, Alkali, and Combined Stresses
edited by and Yiming Zhang
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1019 | Submission Open
Keywords: saline–alkali stress; plant's environmental adaptation mechanisms; metabolism and secondary metabolism; signal transduction; plant–microorganism interaction; omics
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Allergic Asthma submission deadline 30 Nov 2026 | 1 articles | Viewed by 987 | Submission Open
Keywords: allergic asthma; type 2 inflammation; airway remodeling; molecular endotypes; biomarkers; biologic therapies; immune regulation; microRNAs; extracellular vesicles; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine
edited by and
submission deadline 30 Nov 2026 | Viewed by 968 | Submission Open
Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Ferroptosis: Mechanisms and Roles in Diseases
edited by Yuquan Chen
submission deadline 30 Nov 2026 | 1 articles | Viewed by 964 | Submission Open
Keywords: ferroptosis; iron metabolism; lipid peroxidation; oxidative stress; endocrine diseases; metabolic disorders; environmental exposures; circadian rhythm; redox signaling; cell death
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition submission deadline 30 Nov 2026 | 2 articles | Viewed by 930 | Submission Open
Keywords: chronic kidney disease; molecular mechanisms; toxicity mechanisms; inflammation; environmental factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Spectroscopic Techniques in Molecular Sciences, 2nd Edition
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 928 | Submission Open
Keywords: spectroscopy; the structure, dynamics, interactions, and functions of molecules; chemical, biological, pharmaceutical, and materials systems
(This special issue belongs to the Section Biochemistry)
Innovations in Functional Biomaterials for Biomedical Applications
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 926 | Submission Open
Keywords: functional biomaterials; molecular mechanisms; drug delivery systems; tissue engineering; biointerface interactions; smart/stimuli-responsive materials; molecular modeling and simulation; gene and protein expression; biomolecular characterization; regenerative medicine
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms Underlying Plant Responses to Biotic and Abiotic Stress submission deadline 30 Nov 2026 | 1 articles | Viewed by 907 | Submission Open
Keywords: plant stress responses; abiotic stress; biotic stress; signal transduction; multi-omics; epigenetic regulation; plant–microbe interactions; biostimulants; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Photodiagnosis and Photodynamic Therapy submission deadline 30 Nov 2026 | Viewed by 890 | Submission Open
Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool
(This special issue belongs to the Section Molecular Pharmacology)
Emerging Technologies in Musculoskeletal Research: From Molecular Mechanisms to Translational Innovation
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 887 | Submission Open
Keywords: musculoskeletal tissue; cell mechanobiology; biofabrication; tissue regeneration; organ-on-a-chip; disease mechanism and screening; molecular and cellular diagnostics; AI and machine learning; omics technology; wearable technologies; implant technologies; biomarkers; predictive modelling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Interdisciplinary Molecular Design: Catalysis, Therapeutics, and Biomaterials
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 880 | Submission Open
Keywords: intelligent molecular design; computational catalysis; antibody and protein engineering; biomaterials design; molecular dynamics simulations; AI in drug discovery
(This special issue belongs to the Section Molecular Biophysics)
Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 866 | Submission Open
Keywords: skeletal muscle aging; sarcopenia; muscle metabolism; mitochondrial dysfunction; inflammation; exercise adaptation; muscle adaptation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Translational Insights in Solid Tumors: Bridging Molecular Mechanisms to Therapeutic Advances
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 865 | Submission Open
Keywords: solid tumors; translational research; molecular mechanisms; targeted therapy; immunotherapy; tumor microenvironment; biomarkers; drug resistance; precision oncology; clinical translation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cyclodextrins: Properties and Applications, 4th Edition submission deadline 30 Nov 2026 | 2 articles | Viewed by 858 | Submission Open
Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties
(This special issue belongs to the Section Macromolecules)
Emerging Molecular Mechanisms and Therapeutic Targets in Neurodegenerative Diseases and Brain Cancers submission deadline 30 Nov 2026 | 1 articles | Viewed by 854 | Submission Open
Keywords: neuroinflammation; mitochondrial dysfunction; oxidative stress; advanced glycation end products; brain cancers; tumor microenvironment; nutraceutical interventions; plant bioactive molecules; miRNA therapies; oncogenic signaling pathways; blood–brain barrier in brain cancer; immunotherapy
(This special issue belongs to the Section Molecular Neurobiology)
Metabolomics in Functional Foods and Nutritional Health submission deadline 30 Nov 2026 | 1 articles | Viewed by 846 | Submission Open
Keywords: metabolomics; functional foods; bioactive compounds; nutritional health; systems biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Pathogenesis and Targeted Therapies of Hematological Malignancies
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 840 | Submission Open
Keywords: hematological malignancies; precision oncology; molecular mechanisms; therapeutic resistance; targeted therapy; cellular immunotherapies; multi-omics; artificial intelligence; translational medicine
(This special issue belongs to the Section Molecular Oncology)
Novel Diagnostic and Theragnostic Strategies in Brain Tumors
edited by Andrea Cimini and Laura Travascio
submission deadline 30 Nov 2026 | 1 articles | Viewed by 836 | Submission Open
Keywords: brain tumor; novel diagnostic and theragnostic approaches; neuro-oncology; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies—2nd Edition
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 809 | Submission Open
Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Natural Products for Cancer
edited by Ana Carolina Gonçalves
submission deadline 30 Nov 2026 | Viewed by 801 | Submission Open
Keywords: natural products; plant-derived compounds; phenolic compounds; pharmacodynamics; pharma-cokinetics; antioxidant capacities; cancer; oxidative stress-related disorders; in vivo assays; in vitro assays; clinical assays; mechanisms of differentiation; tissue homeostasis
(This special issue belongs to the Section Molecular Oncology)
Bioactive Food Ingredients and Precision Nutrition: From Molecular Innovation to Clinical Relevance
edited by Lídia Pinheiro and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 778 | Submission Open
Keywords: bioactive food ingredients; functional foods; nutraceuticals; precision nutrition; gut microbiota; delivery systems; omics technologies; AI in nutrition; personalized nutrition; immune modulation; neuroprotection
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Translational Advances in Melanoma Molecular Research submission deadline 30 Nov 2026 | 1 articles | Viewed by 775 | Submission Open
Keywords: melanoma; molecular targets; resistance mechanism; future advances; metabolic reprogramming
(This special issue belongs to the Section Molecular Oncology)
Plant Viruses: Discovery and Genetic Diversity
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 770 | Submission Open
Keywords: novel virus; discovery; high-throughput sequencing; diversity; population geneticss; evolutionary dynamic
(This special issue belongs to the Section Molecular Plant Sciences)
Zinc Signaling in Immunity
edited by and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 769 | Submission Open
Keywords: zinc signaling; zinc flux; zinc sparks; zinc wave; zinc transporter
(This special issue belongs to the Section Biochemistry)
Interaction Between Gut Microbiota and Food Bioactive Compounds
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 763 | Submission Open
Keywords: gut microbiota; bioactive compounds; microbial metabolites; host–microbe interactions; molecular mechanisms; host signaling pathways; nutritional intervention; gut–diet–health axis; microbiota modulation; metagenomic/metatransxriptomics; prebiotics/probiotics/synbiotics; intestinal barrier function
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Modern Synthetic Pathways for Anticancer Drug Discovery
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 744 | Submission Open
Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry
(This special issue belongs to the Section Molecular Oncology)
Effects of Natural Bioactive Compounds on Cellular Responses
edited by
submission deadline 30 Nov 2026 | Viewed by 741 | Submission Open
Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biometallic Nanoparticles: Synthesis, Functionalization and Multidisciplinary Applications
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 723 | Submission Open
Keywords: biogenic nanomaterials; antibacterial agents; plant extracts; biogenic silver nanoparticles; biofilms; cytotoxicity
(This special issue belongs to the Section Molecular Nanoscience)
Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 688 | Submission Open
Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells
(This special issue belongs to the Section Molecular Oncology)
Current Research on Choroid Plexus
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 663 | Submission Open
Keywords: choroid plexus; blood–cerebrospinal fluid barrier; cerebrospinal fluid; neurological diseases; brain homeostasis
(This special issue belongs to the Section Molecular Neurobiology)
State-of-the-Art Molecular Pharmacology in Thailand submission deadline 30 Nov 2026 | 1 articles | Viewed by 636 | Submission Open
Keywords: molecular pharmacology; pharmacogenomics; bioactive natural products; drug discovery and design; molecular targets; precision medicine; signal transduction; cholangiocarcinoma therapeutics; neuropharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Transcription Factors in Plant Gene Expression Regulation, 3rd Edition
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 632 | Submission Open
Keywords: plant trans-factor ; cis-active sequence ; post-translational modification ; dimerization and oligomerization ; DNA modules
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Skin Inflammation (2nd Edition)
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 630 | Submission Open
Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Research on Skin Pigmentation and Photoaging
edited by Chang-Cheng Chang and
submission deadline 30 Nov 2026 | Viewed by 629 | Submission Open
Keywords: skin pigmentation; melasma; photoaging; energy-based devices; skin rejuvenation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes submission deadline 30 Nov 2026 | Viewed by 625 | Submission Open
Keywords: drug-induced toxicity; drug-drug interactions; drug delivery systems; toxicity; disease
(This special issue belongs to the Section Molecular Toxicology)
Transition-Metal-Based Nanoparticles: Synthesis, Properties and Applications
edited by Ramin Yousefi and
submission deadline 30 Nov 2026 | Viewed by 607 | Submission Open
Keywords: transition metal nanoparticles; synthesis; structure–property relationship; catalysis; photocatalysis; energy storage and conversion; biomedical applications; drug delivery; environmental remediation; plasmonics
(This special issue belongs to the Section Molecular Nanoscience)
Metabolic Diseases: From Molecular Mechanisms to Innovative Therapeutics
edited by and Anna D. Serefko
submission deadline 30 Nov 2026 | Viewed by 605 | Submission Open
Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut–brain axis; innovative therapeutic strategies; natural compounds; drug repurposing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Amyotrophic Lateral Sclerosis
edited by
submission deadline 30 Nov 2026 | Viewed by 597 | Submission Open
Keywords: amyotrophic lateral sclerosis; proteomics; protein aggregation; mitochondria; neurodegeneration; RNA metabolism; oxidative stress; neuroinflammation; systems biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Reproductive Genetics and Genomics in Crop Breeding submission deadline 30 Nov 2026 | 1 articles | Viewed by 590 | Submission Open
Keywords: genetics; heredity; agronomy; maize breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Cancer Biomarkers: From Early Detection to Prognosis
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 590 | Submission Open
Keywords: cancer biomarkers; early detection; prognosis; liquid biopsy; personalized oncology; multi-omics; translational research; predictive modeling
(This special issue belongs to the Section Molecular Oncology)
Kidney Disease: From Biomarkers, Molecular Mechanisms to Targeted Therapy
edited by
submission deadline 30 Nov 2026 | Viewed by 585 | Submission Open
Keywords: kidney disease; biomarkers; molecular mechanisms; precision nephrology; chronic kidney disease; acute kidney injury; renal fibrosis; omics technologies; targeted therapy; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation: Emerging Insights and Advances in Drug Development submission deadline 30 Nov 2026 | Viewed by 577 | Submission Open
Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’s disease; Alzheimer’s disease; multiple scleroris; stroke
(This special issue belongs to the Section Molecular Neurobiology)
Roles of Erythrocytes in Human Health and Disease: 4th Edition
edited by
submission deadline 30 Nov 2026 | Viewed by 551 | Submission Open
Keywords: erythrocytes; red blood cells; red blood functions; vascular function; blood bank storage
(This special issue belongs to the Section Molecular Biology)
Research Advances in Vegetable Breeding and Genetics
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 551 | Submission Open
Keywords: vegetable; breeding; genetics; genomics; gene editing; marker-assisted selection; stress resistance; quality improvement; crop improvement; horticulture
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Foodborne Pathogens and Biofilms submission deadline 30 Nov 2026 | 1 articles | Viewed by 550 | Submission Open
Keywords: foodborne pathogens; biofilms; food
(This special issue belongs to the Section Molecular Microbiology)
Quantum Chemical Intelligence: New Horizons of Molecular Structure and Reactivity
edited by
submission deadline 30 Nov 2026 | Viewed by 538 | Submission Open
Keywords: chemical bond and bonding; quantum states and measurements; chemical reactivity; valence models; complex coordination; reaction coordinates and paths; bio-nano-materials
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Hormetic Responses of Plants to Environmental Stress
edited by
submission deadline 30 Nov 2026 | Viewed by 534 | Submission Open
Keywords: hormesis; environmental stress; dose–response; molecular mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
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