Translational Insights in Solid Tumors: Bridging Molecular Mechanisms to Therapeutic Advances
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 5
Special Issue Editor
Interests: translational oncology; PDAC; breast cancer; novel therapeutic
Special Issue Information
Dear Colleagues,
Despite significant advances in oncology, solid tumors continue to pose substantial unmet medical needs, with high mortality rates driven by late diagnosis, therapy resistance, metastasis, and limited treatment options in advanced stages. Pancreatic, lung, colorectal, and other aggressive solid malignancies still suffer from poor long-term survival, underscoring the urgent requirement for deeper molecular insights and more effective translational strategies.
This Special Issue is particularly timely as rapid progress in molecular profiling, tumor microenvironment research, and emerging technologies is creating unprecedented opportunities to translate basic discoveries into novel therapeutic approaches. By integrating cutting-edge mechanistic understanding with clinical applications, this issue aims to accelerate the development of precision oncology solutions that address these critical gaps and improve patient outcomes.
We invite original research articles, reviews, and perspectives that explore the continuum from basic science to clinical translation in solid tumors, with a particular emphasis on studies demonstrating clear therapeutic relevance or potential for clinical impact.
Topics of interest include, but are not limited to, the following:
- Molecular and genetic mechanisms underlying tumor initiation, progression, and metastasis with translational or therapeutic implications;
- Tumor microenvironment and immune interactions relevant to therapeutic targeting;
- Biomarker discovery and validation for diagnosis, prognosis, and therapy selection;
- Advances in targeted therapies, immunotherapies, and combination strategies;
- Mechanisms of drug resistance and approaches to overcome them;
- Emerging technologies (e.g., single-cell omics, spatial biology, AI-driven approaches) applied to therapeutic development;
- Preclinical models and their translational relevance to human disease;
- Clinical trials and real-world evidence informing therapeutic innovation;
- This Special Issue particularly encourages interdisciplinary studies that connect mechanistic insights with therapeutic applications and clinical progress, fostering advancements toward precision oncology.
We look forward to receiving your contributions.
Dr. Samarpan Majumder
Guest Editor
Manuscript Submission Information
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Keywords
- solid tumors
- translational research
- molecular mechanisms
- targeted therapy
- immunotherapy
- tumor microenvironment
- biomarkers
- drug resistance
- precision oncology
- clinical translation
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