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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Mitochondria in Neurodegenerative Diseases
edited by Małgorzata Wojtkowska
submission deadline 30 Dec 2025 | Viewed by 247 | Submission Open
Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Obesity Research: Metabolic Pathways and Pathophysiological Factors
edited by Aleksandra Stefanović
submission deadline 30 Dec 2025 | Viewed by 242 | Submission Open
Keywords: obesity; inflammation; oxidative stress; obesity-related diseases; adypocitokines
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Basis for Sustainable Management of Migratory Insects
edited by
submission deadline 30 Dec 2025 | Viewed by 228 | Submission Open
Keywords: migrant insects; molecular basis of population growth; migration and reproduction; migration and immunity; migration and diapause; migration and orientation; molecular regulation of migration
(This special issue belongs to the Section Molecular Biology)
Role of Immune and Inflammatory Cells in Pulmonary Diseases
edited by Remo C. Russo
submission deadline 30 Dec 2025 | Viewed by 204 | Submission Open
Keywords: idiopathic pulmonary fibrosis (IPF); pulmonary immunology; precision medicine; single-cell RNA sequencing (scRNA-seq); spatial transcriptomics sequencing; animal model of pulmonary fibrosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Immune-Modulating Therapies and Cutting-Edge Technologies for Immune-Related Diseases
edited by
submission deadline 30 Dec 2025 | Viewed by 203 | Submission Open
Keywords: immune heomostasis; immune related diseases; small molecules; cell therapy; bacteria and virus; antibodies
(This special issue belongs to the Section Molecular Immunology)
Synthesis, Characterization and Applications of Advanced Polymer Materials
edited by Namil Kim
submission deadline 30 Dec 2025 | Viewed by 187 | Submission Open
Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications
(This special issue belongs to the Section Macromolecules)
Machine Learning in Disease Diagnosis and Treatment: 2nd Edition
edited by
submission deadline 30 Dec 2025 | Viewed by 178 | Submission Open
Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Immunotherapy in Cancer
edited by Magdalena Król
submission deadline 30 Dec 2025 | Viewed by 173 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies
(This special issue belongs to the Section Molecular Immunology)
Epigenetic Regulation in Cell Development, Differentiation and Cell Fate
edited by Gang Ren
submission deadline 30 Dec 2025 | Viewed by 161 | Submission Open
Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer– promoter interaction; histone modification; epigenetic variation; complex traits
(This special issue belongs to the Section Molecular Genetics and Genomics)
Telocytes: Unraveling Their Roles in Health and Disease
edited by
submission deadline 30 Dec 2025 | Viewed by 158 | Submission Open
Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells
(This special issue belongs to the Section Molecular Biology)
Cellular Physiology and Aging: Membrane Dynamics, Intracellular Environment and Signaling Pathways
edited by , and Sara Spinelli
submission deadline 30 Dec 2025 | Viewed by 155 | Submission Open
Keywords: aging; oxidative stress; ion channels; antioxidant molecules; membrane transport systems; redox signaling; cellular senescence; inflammation; intracellular signaling pathways; mitochondrial dysfunction; bioactive compounds; cell physiology; homeostasis; longevity; age-related diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research in RNA–Protein Networks
edited by Hidenori Tani
submission deadline 30 Dec 2025 | Viewed by 147 | Submission Open
Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA– protein complex; alternative splicing; RNA stability; RNA localization
(This special issue belongs to the Section Molecular Biology)
Cellular Mechanisms of Pulmonary Arterial Hypertension
edited by and Saurabh Aggarwal
submission deadline 30 Dec 2025 | Viewed by 144 | Submission Open
Keywords: pulmonary arterial hypertension (PAH); pulmonary vascular remodeling; endothelial cells; endothelial dysfunction; smooth muscle cells; hyperplasia; pericytes; fibroblasts; monocytes; macrophage; neutrophil; mechanotransduction; oxidative stress; cytokines; extracellular vesicles; extracellular matrix; epigenetics; metabolism; biomarkers; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products in Immune Regulation
edited by
submission deadline 30 Dec 2025 | Viewed by 141 | Submission Open
Keywords: natural products; immune responses; immunomodulatory therapies
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Biology of Pregnancy Complications
edited by Elżbieta Poniedziałek-Czajkowska and Radzisław Mierzyñski
submission deadline 30 Dec 2025 | Viewed by 137 | Submission Open
Keywords: molecular biology of pregnancy complications; maternal pregnancy complications; neonatal pregnancy complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes
edited by
submission deadline 30 Dec 2025 | Viewed by 132 | Submission Open
Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Role of Microorganisms and Their Metabolites in Agriculture, Food and the Environment: 3rd Edition
edited by
submission deadline 30 Dec 2025 | Viewed by 128 | Submission Open
Keywords: fermentation; biopreservation; biocontrol; biodegradation; bioremediation; bioaugmentation; omic-technologies
(This special issue belongs to the Section Molecular Microbiology)
New Breakthroughs in Molecular Diagnostic Tools for Human Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | Viewed by 120 | Submission Open
Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; the molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; the experimental models of injury and diseases; the targeted therapy of injuries and diseases; drug abuse; histological diagnosis; the epigenetics of organs injuries; miRNA and the prognosis of diseases; novel approaches and proofs of principle in therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Crossroads in Cardiac Pathophysiology
edited by
submission deadline 30 Dec 2025 | Viewed by 114 | Submission Open
Keywords: cardiometabolic disease; cardiac metabolism; heart failure; mitochondrial dysfunction; insulin resistance; cardiometabolic therapies; metabolomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Biomarkers and New Therapeutic Options in Neoplastic Diseases
edited by
submission deadline 30 Dec 2025 | Viewed by 106 | Submission Open
Keywords: biomarkers; neoplastic diseases; molecular targets; targeted therapy; precision oncology; signaling pathways; cancer diagnostics; therapeutic options; drug resistance; molecular profiling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition
edited by Antonella Ciabattoni and Fabiana Gregucci
submission deadline 30 Dec 2025 | Viewed by 98 | Submission Open
Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy
(This special issue belongs to the Section Molecular Oncology)
The Role of Diet in Lipid and Lipoprotein Metabolism
edited by
submission deadline 30 Dec 2025 | Viewed by 98 | Submission Open
Keywords: dyslipidemia; hypertension; diabetes; dementia
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage
edited by Antonio Arnaiz-Villena
submission deadline 30 Dec 2025 | Viewed by 80 | Submission Open
Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G; E; F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal  MHC; Veterinary
(This special issue belongs to the Section Molecular Immunology)
Research on the Key Role of Ubiquitination in Signaling and Cancer
edited by
submission deadline 30 Dec 2025 | Viewed by 69 | Submission Open
Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development
(This special issue belongs to the Section Molecular Oncology)
Effects of Bioactive Compounds in Oxidative Stress and Inflammation submission deadline 31 Dec 2025 | 9 articles | Viewed by 28972 | Submission Open
Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Schizophrenia: From Molecular Mechanism to Therapy submission deadline 31 Dec 2025 | 7 articles | Viewed by 22498 | Submission Open
Keywords: schizophrenia; neurodevelopmental disorders; therapeutic approaches; drug of abuse; mental disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Research on Plant Bioactive Compounds submission deadline 31 Dec 2025 | 9 articles | Viewed by 16986 | Submission Open
Keywords: plant bioactive compounds; extraction and analysis of plant bioactive compounds; bioactivity and pharmacokinetics of plant compounds; natural products and modern diseases; plant bioactive compounds and by-products; discovery and development of natural plant drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research Progress of Metabolomics in Health and Disease submission deadline 31 Dec 2025 | 10 articles | Viewed by 16191 | Submission Open
Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques
(This special issue belongs to the Section Molecular Biology)
The Role of Lipids in Health and Diseases
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 15689 | Submission Open
Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism
(This special issue belongs to the Section Biochemistry)
Phyto-Functional Nanomaterials: Synthesis, Characterization and Application submission deadline 31 Dec 2025 | 8 articles | Viewed by 14503 | Submission Open
Keywords: phyto-functional nanomaterials; green synthesis; hydrogen generation; pollutant degradation/removal; fine chemistry; photoinactivation; cancer; microorganisms
(This special issue belongs to the Section Molecular Nanoscience)
Natural Products in Drug Discovery and Development
edited by Tian-Le Gao
submission deadline 31 Dec 2025 | 10 articles | Viewed by 13925 | Submission Open
Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery
(This special issue belongs to the Section Molecular Pharmacology)
Editorial Board Members’ Collection Series: Cancer Metastasis submission deadline 31 Dec 2025 | 5 articles | Viewed by 13914 | Submission Open
Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles
(This special issue belongs to the Section Molecular Oncology)
The Impact of Natural Bioactive Compounds on Human Health and Disease
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 12752 | Submission Open
Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug
(This special issue belongs to the Section Molecular Pharmacology)
Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 10022 | Submission Open
Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research in Bamboo, Tree, Grass, and Other Forest Products
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 9338 | Submission Open
Keywords: bamboo; tree; grass; molecular biology; gene function
(This special issue belongs to the Section Molecular Plant Sciences)
25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 9227 | Submission Open
Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics; proteomics; transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Oncology
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 8551 | Submission Open
Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy
(This special issue belongs to the Section Molecular Oncology)
25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 8365 | Submission Open
Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Coordination Complexes: From Molecular Design to Functional Applications
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7686 | Submission Open
Keywords: coordination complexes; organometallic complexes; functional materials; metal– ligand interactions; homogenous catalysis; sensing; magnetic materials; ligand tunability
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
25th Anniversary of IJMS: Updates and Advances in Macromolecules submission deadline 31 Dec 2025 | 3 articles | Viewed by 6430 | Submission Open
Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship
(This special issue belongs to the Section Macromolecules)
Recent Progress in Metabolic Diseases
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5633 | Submission Open
Keywords: metabolic diseases; enzymes related to metabolic disorders; inborn errors of metabolism; inherited single-gene anomalies; molecular diagnostics in metabolic disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Animal Models for Human Diseases
edited by Yuning Song
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5184 | Submission Open
Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Delivery of Nucleic Acids
edited by Yong-Serk Park
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4960 | Submission Open
Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy
(This special issue belongs to the Section Molecular Biology)
Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4607 | Submission Open
Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain
(This special issue belongs to the Section Molecular Immunology)
Dietary Supplements: A Delicate Balance Between Benefit and Harm
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 4332 | Submission Open
Keywords: dietary supplements; antioxidants; skin; ageing; wellness
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advancements in Diagnostic and Preventive Pharmacogenomics
edited by Alireza Tafazoli
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4282 | Submission Open
Keywords: genome profiling; pharmacogenetic analysis; diagnostic pharmacogenomics; pre-emptive pharmacogenomics; advanced genotyping technologies
(This special issue belongs to the Section Molecular Pharmacology)
25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience
edited by Qi Zhang, and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 4236 | Submission Open
Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes
(This special issue belongs to the Section Molecular Nanoscience)
Advances in the Relationship Between Diet and Insulin Resistance
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4163 | Submission Open
Keywords: insulin resistance; lipotoxicity; lipid metabolism; type 2 diabetes mellitus; dietary lipids; lipidomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics submission deadline 31 Dec 2025 | 3 articles | Viewed by 4091 | Submission Open
Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers submission deadline 31 Dec 2025 | 1 articles | Viewed by 3711 | Submission Open
Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research
(This special issue belongs to the Section Molecular Oncology)
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