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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs

edited by Marta Chagas Monteiro,

Nélio Teixeira Machado

and Pedro Roosevelt Romão

submission deadline 20 Oct 2025 | Viewed by 464 | Submission Open

Keywords: waste biomass; thermochemical processes; bio-oils; phenolic compounds; anti-inflammatory actions; antiviral mechanisms; cancer; cytokine/chemokine regulation; inflammatory conditions/diseases; innate immunity; immune response; immunomodulatory and anti-infective effects; immunomodulation; immunotoxicology; medicinal chemistry; neglected tropical diseases; parasitic disease; purinergic signaling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Pathophysiology of Myocardial Disease, 2nd Edition

edited by

Ryan D. Sullivan

Inna P. Gladysheva

and Hongyu Qiu

submission deadline 20 Oct 2025 | 1 articles | Viewed by 452 | Submission Open

Keywords: myocardial disease; cardiomyopathy; fibrosis and remodeling; inflammation; hypertension; heart failure; cardiometabolic; cardio-renal; heart-liver axis; comorbidity; molecular mechanisms; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanocomposites and Their Biomedical Applications

edited by

Azeem Ullah

and Zhen Zhang

submission deadline 20 Oct 2025 | Viewed by 446 | Submission Open

Keywords: targeted drug delivery; tissue engineering; edible coatings; controlled release; wound healing; bioactive packaging; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Heavy Metal Toxicity and Female Infertility, Pregnancy Disorders, Fetal Growth and Development

edited by

Sakhila K. Banu

submission deadline 20 Oct 2025 | Viewed by 441 | Submission Open

Keywords: pregnancy disorders; preeclampsia; pre-term labor; endometriosis; infertility; uterine artery remodeling; ovarian failure; polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF)]; fetal growth restriction; placental pathogenesis

(This special issue belongs to the Section Molecular Toxicology)

Membrane Proteins and Ion Channels

edited by

Sheng-Nan Wu

submission deadline 20 Oct 2025 | Viewed by 434 | Submission Open

Keywords: membrane proteins; ion channels; cell membranes

(This special issue belongs to the Section Molecular Biophysics)

Recent Advancements in Studying Biomacromolecule–Ligand Interactions

edited by

Guo-Ping Zhou

submission deadline 20 Oct 2025 | Viewed by 431 | Submission Open

Keywords: biomacromolecule– ligand interaction; X-ray crystallography; nuclear magnetic resonance (NMR) spectroscopy; surface plasmon resonance (SPR); isothermal titration calorimetry (ITC); fluorescence spectroscopy (FS); mass spectrometry (MS); drug discovery

(This special issue belongs to the Section Macromolecules)

Molecular Pharmacology and Metabolic Signaling in Health and Disease

edited by

Prasanth Puthanveetil

submission deadline 20 Oct 2025 | Viewed by 424 | Submission Open

Keywords: molecular pharmacology; cellular signaling; signal transduction; mechanism of drugs; altered metabolism in disease states; systemic metabolism and health; altered synthesis and secretion of endogenous agents; lifestyle modifications; diet and exercise

(This special issue belongs to the Section Molecular Pharmacology)

Advancements in Protein Engineering and Structure Determination

edited by Ivan Campeotto and Shabir Najmudin

submission deadline 20 Oct 2025 | Viewed by 420 | Submission Open

Keywords: protein engineering; protein structure; protein design; protein modelling; protein stability

(This special issue belongs to the Section Molecular Biology)

Heart Failure and Cardiac Remodeling: Molecular Mechanisms and Therapeutic Strategies

edited by

Antonio Lax

submission deadline 20 Oct 2025 | Viewed by 419 | Submission Open

Keywords: heart failure; cardiac remodeling; molecular mechanisms; therapeutic strategies; cardiomyopathy; biomarkers; gene therapy; regenerative medicine; pharmacology; inflammation; fibrosis; signal transduction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Medicinal Mechanism of Natural Products in Cancer Therapies

edited by

Clement G. Yedjou

submission deadline 20 Oct 2025 | Viewed by 377 | Submission Open

Keywords: natural product; phytochemicals; protein– ligand interaction; mechanism of action; drug discovery; prevention; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Applications of Deep Learning in Kidney Diseases

edited by

Michele Provenzano

Vincenzo Pezzi

and

Gianluigi Zaza

submission deadline 20 Oct 2025 | Viewed by 361 | Submission Open

Keywords: kidney biomarkers; kidney diseases; predictive biomarkers; deep learning; personalized therapy; digital health

(This special issue belongs to the Section Molecular Informatics)

Molecular Research Progress of Antibacterial Material

edited by

Victor M. Castano

submission deadline 20 Oct 2025 | Viewed by 360 | Submission Open

Keywords: antibacterial; microcides; nanoparticles; nanostructures; molecular engineering; ROS induction

(This special issue belongs to the Section Materials Science)

Nose-to-Brain Drug Delivery: Opportunities and Challenges

edited by

Daisuke Inoue

submission deadline 20 Oct 2025 | Viewed by 359 | Submission Open

Keywords: nose-to-brain drug delivery; brain drug delivery system; CNS diseases; intranasal administration; nasal formulation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms Underlying Pancreatic Cancer Progression and Drug Resistance

edited by Daoyan Wei and Robert S. Bresalier

submission deadline 20 Oct 2025 | Viewed by 354 | Submission Open

Keywords: pancreatic cancer; cancer progression; therapeutic resistance; targeted therapies; oncogenic pathways; molecular pathogenesis; tumor heterogeneity; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Antituberculous Drugs: Progress and Challenges

edited by Ana Maria Telmo Dias Pereira Vicente Cabral and

Ana Cristina Faria Ribeiro

submission deadline 20 Oct 2025 | Viewed by 354 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Molecular Research of Nuclear Receptors in Disease

edited by Shigeaki Kato

submission deadline 20 Oct 2025 | Viewed by 334 | Submission Open

Keywords: nuclear receptors; steroid hormones; fat-soluble vitamins; cancer; non-communicable diseases; synthetic ligands

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases: Second Edition

edited by Marzena Helena Olesińska and Magdalena Szmyrka

submission deadline 20 Oct 2025 | Viewed by 324 | Submission Open

Keywords: autoimmune rheumatic diseases; inflammatory rheumatic diseases; arthritis; connective tissue diseases

(This special issue belongs to the Section Molecular Immunology)

Germline Mutations, Somatic Mutations and Their Phenotypic Effects in Humans and Animals

edited by

Teruaki Tozaki

submission deadline 20 Oct 2025 | Viewed by 322 | Submission Open

Keywords: germline mutations; somatic mutations; genetic disorders; single nucleotide variant (SNV); insertion; deletion; copy number variation (CNV); structure variation (SV); sports enhancement; cancer; melanoma; coat color

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Cellular Mechanisms in Mood Disorders

edited by Sara Palumbo

submission deadline 20 Oct 2025 | Viewed by 313 | Submission Open

Keywords: neurobiology of mood disorders; intracellular signalling in mood disorders; neurophysiological alterations in mood disorders; genetic risk of mood disorders; pharmacological targets for mood disorders

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Sjögren's Syndrome, 4th Edition

edited by

Biji Theyilamannil Kurien

submission deadline 20 Oct 2025 | Viewed by 305 | Submission Open

Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modulation of Protein Structure and Function by Lipids: 2nd Edition

edited by

Avia Rosenhouse-Dantsker

submission deadline 20 Oct 2025 | Viewed by 299 | Submission Open

Keywords: protein modulation by lipids; phosphoinositides; cholesterol; sterols; fatty acids; G protein-coupled receptors; ion channels; transporters

(This special issue belongs to the Section Biochemistry)

Molecular Mechanism of Diabetes and Its Complications

edited by Michishige Terasaki

submission deadline 20 Oct 2025 | Viewed by 297 | Submission Open

Keywords: diabetes; hyperglycemia; oxidative stress; atherosclerosis; comorbidity; complication; metabolic metabolic dysfunction associated steatotic liver disease (MASLD); steatohepatitis (MASH); chronic kidney disease (CKD); heart failure; heart failure with preserved ejection fraction (HFpEF); coronary artery disease (CAD)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Research in Novel Immune Adjuvants

edited by Bei Li

submission deadline 20 Oct 2025 | Viewed by 293 | Submission Open

Keywords: adjuvants; vaccine; immunology; toxicology; biology

(This special issue belongs to the Section Molecular Immunology)

Functional Polymeric Materials: From Synthesis to Applications: 2nd Edition

edited by

Marta Fernández-García

and

Alexandra Muñoz-Bonilla

submission deadline 20 Oct 2025 | 1 articles | Viewed by 289 | Submission Open

Keywords: natural polymers; bio-based polymers; block copolymers; micelles; polymer chemistry; (hydro)gels; (bio)applications; degradability

(This special issue belongs to the Section Materials Science)

Wheat-Related Intestinal Diseases: From Molecular Basis to Potential Therapy

edited by Alessandra Camarca and Vera Rotondi-Aufiero

submission deadline 20 Oct 2025 | Viewed by 267 | Submission Open

Keywords: CeD pathogenesis; NCWS molecular basis; therapies alternative to GFD; gluten digestion strategies; gluten detoxification strategies; experimental models; new tools and/or biomarkers for diagnosis and follow-up

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition

edited by

Anna Duda-Madej

submission deadline 20 Oct 2025 | 1 articles | Viewed by 265 | Submission Open

Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Chemokine and Chemokine Receptor in Human Physiological and Pathological Processes

edited by

Cinzia Giagulli

submission deadline 20 Oct 2025 | Viewed by 265 | Submission Open

Keywords: chemokines; chemokine receptors; cancer; inflammatory disease; pathogens; immune system; homeostasis

(This special issue belongs to the Section Molecular Immunology)

Bioactive Molecules from Food Waste in Food Packaging Applications

edited by

Jennifer Gubitosa

submission deadline 20 Oct 2025 | Viewed by 263 | Submission Open

Keywords: wastes upcycling; waste management; circular economy; green chemistry; bioactive molecules; agri-food wastes and by-products; food packaging; active packaging

(This special issue belongs to the Section Materials Science)

Neuronal Differentiation: From Pathology to Therapeutic Strategies

edited by

Marzia Lecchi

submission deadline 20 Oct 2025 | Viewed by 261 | Submission Open

Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells

(This special issue belongs to the Section Molecular Neurobiology)

Melanin Pigmentation: Physiology and Pathology

edited by

Shosuke Ito

and

Manickam Sugumaran

submission deadline 20 Oct 2025 | Viewed by 258 | Submission Open

Keywords: eumelanin; pheomelanin; melanogenesis; photoprotection; pigmentary disorders; depigmenting agents; extracutaneous melanins

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein-Based Composite Materials: 2nd Edition

edited by

Xiao Hu

submission deadline 20 Oct 2025 | Viewed by 257 | Submission Open

Keywords: protein biopolymer; composite film; fiber; foam; gel; particle; sensor; and device; biomacromolecules and functional materials; polymer composite design and characterization; protein physical and chemical properties

(This special issue belongs to the Section Materials Science)

p53 in Cell Death and Cellular Senescence

edited by

Ji Hoon Jung

submission deadline 20 Oct 2025 | Viewed by 255 | Submission Open

Keywords: p53; apoptosis; ferroptosis; senescence; cancer cell

(This special issue belongs to the Section Biochemistry)

Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications

edited by Karim Daliri

submission deadline 20 Oct 2025 | Viewed by 253 | Submission Open

Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9

(This special issue belongs to the Section Molecular Biology)

Phenotypes to Genotypes: Breaking the Chains of EGFR Addiction in Lung Cancer

edited by

Massimiliano Mancini

submission deadline 20 Oct 2025 | Viewed by 247 | Submission Open

Keywords: EGFR-mutant lung cancer; EGFR; NSCLC; tumor heterogeneity; resistance mechanisms

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Chronic Obstructive Pulmonary Diseases

edited by

Evangelia Fouka

submission deadline 20 Oct 2025 | Viewed by 242 | Submission Open

Keywords: COPD; epigenetics; mitochondrial dysfunction; autophagy; proteomics; single-cell sequencing; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathways of Proteostasis in Aging and Diseases

edited by Emmanouil Kyriakakis

submission deadline 20 Oct 2025 | Viewed by 241 | Submission Open

Keywords: proteostasis; aging; neurodegenerative diseases; UPR; autophagy; ER stress; HSR; longevity; healthspan; quality control mechanisms; muscle atrophy; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 20 Oct 2025 | Viewed by 236 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

Telomeres in Development, Senescence and Genome Instability: 2nd Edition

edited by Michal Zalzman

submission deadline 20 Oct 2025 | Viewed by 229 | Submission Open

Keywords: telomere disorders and cell death; telomere factors as therapeutic targets in cancer; telomeres and genome stability; telomeres in aging and senescence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pain Chronicity and Relief: From Molecular Basis to Rehabilitation

edited by

Katsuya Kami

submission deadline 20 Oct 2025 | Viewed by 227 | Submission Open

Keywords: exercise-induced hypoalgesia; barrier factor; chronic pain; neuropathic pain; spinal cord dorsal horn; mesocorticolimbic system; myokine; descending pain modulatory system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Crosstalk Between Bioactive Compounds and Disease

edited by

Mónica Carrera

submission deadline 20 Oct 2025 | Viewed by 227 | Submission Open

Keywords: bioactive compounds; human health; omics technologies; nanotechnology; drug development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Approaches in Drug Discovery: From Natural Products to Therapeutic Innovations

edited by

Kazuhiko Nakadate

submission deadline 20 Oct 2025 | Viewed by 224 | Submission Open

Keywords: natural product-derived compounds; drug discovery; medicinal chemistry; disease prevention; therapeutic innovation; artificial intelligence in drug discovery; high-throughput screening; omics technologies; drug delivery systems; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Macrophages in Inflammatory and Cancer: An Update

edited by

José Luis Reyes

submission deadline 20 Oct 2025 | Viewed by 220 | Submission Open

Keywords: macrophages; cancer; inflammation; cell therapy

(This special issue belongs to the Section Molecular Immunology)

Triosephosphate Isomerase: Potential Target in Cancer Treatment and Other Diseases

edited by

Gabriel López-Velázquez

submission deadline 20 Oct 2025 | Viewed by 219 | Submission Open

Keywords: cancer; glycolytic; triosephosphate isomerase; TPI; post-translational modification; cancer treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pulmonary Hypertension: Molecular Diagnosis, Pathogenesis, Biomarkers and Therapies

edited by Michele Correale

submission deadline 20 Oct 2025 | Viewed by 218 | Submission Open

Keywords: pulmonary hypertension; pulmonary arterial hypertension; pulmonary vascular disease; pulmonary circulation; cor pulmonale; chronic lung disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Musculoskeletal Physiology: Mechanical Stimulation, Mechanical Disuse and Hormone Signaling

edited by Whitney A. Bullock

submission deadline 20 Oct 2025 | Viewed by 185 | Submission Open

Keywords: mechanotransduction; musculoskeletal; hormonal signaling; muscle– bone crosstalk; mechanical stimuli; mechanical disuse

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Application of Hyaluronan in Tissue Healing

edited by

Antonella D'Agostino

submission deadline 20 Oct 2025 | Viewed by 178 | Submission Open

Keywords: wound healing; inflammation; remodeling; chronic wound; wound dressing; scar tissue; sound tissue; biomarkers; chemical modification; crosslinked; biopolymer; biological activity

(This special issue belongs to the Section Macromolecules)

Hyaluronan and Proteoglycans in Cancer and Inflammatory Diseases: Molecular Mechanisms and Therapeutic Implications

edited by Angela D’Ascola and

Michele Scuruchi

submission deadline 20 Oct 2025 | Viewed by 136 | Submission Open

Keywords: hyaluronan; proteoglycans; inflammation; cancer; tumor microenvironment; therapy

(This special issue belongs to the Section Molecular Oncology)

Progress in Astrocyte Research

edited by Carla Caruso

submission deadline 20 Oct 2025 | Viewed by 125 | Submission Open

Keywords: astrocyte biology; astrocyte heterogeneity; astrocyte metabolism; astrocyte-derived extracellular vesicles; neuroinflammation; neurodegeneration; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Plant Physiology and Molecular Nutrition: 2nd Edition

edited by

Shu Yuan

and