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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bacterial Adaptation Strategies to the Host: From Acute, Aggressive to Chronic, Dormant Infections, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 5194 | Submission Open
Keywords: dormancy; phenotype switching; bacterial stress; survival strategies; persisters; resuscitation; starvation; cell cycle arrest; ATP homeostasis
(This special issue belongs to the Section Molecular Microbiology)
Cellular and Molecular Biology in the Compromised Neonate
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 5028 | Submission Open
Keywords: compromised neonate; infections; placental dysfunction; disrupted oxygen supply; molecular and cellular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
TRP Channels for Pain, Itch and Inflammation Relief: 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 4926 | Submission Open
Keywords: TRP channels; “ thermoTRP” channels; neuropathic pain; inflammatory pain; cancer pain; pruritic skin iseases; itch; neurogenic inflammation; migraine
(This special issue belongs to the Section Molecular Immunology)
Molecular Genetics of Breast Cancer—Recent Progress
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4892 | Submission Open
Keywords: hereditary cancer; female breast cancer; male breast cancer; molecular oncology; cancer genetics; NGS of gene panels; transcriptomics; genetic predisposition to breast cancer; breast cancer risk; tumor profiling; predictive biomarkers; personalized treatment
(This special issue belongs to the Section Molecular Oncology)
Molecular Genetics and Breeding Mechanisms in Domestic Animals: 3rd Edition
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 4877 | Submission Open
Keywords: animal genetics; animal breeding; functional genomics; multiomics analysis; molecular immunity; interactions between microbe and host
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 4855 | Submission Open
Keywords: brain; brain cancer; depression; neurodegenerative disorders; natural compounds
(This special issue belongs to the Section Molecular Neurobiology)
The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology submission deadline 20 Sep 2025 | 4 articles | Viewed by 4836 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines
(This special issue belongs to the Section Molecular Immunology)
Small Molecule Drug Design and Research: 3rd Edition
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 4794 | Submission Open
Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques
(This special issue belongs to the Section Molecular Pharmacology)
Role of Natural Products in Health and Diseases submission deadline 20 Sep 2025 | 3 articles | Viewed by 4774 | Submission Open
Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity
(This special issue belongs to the Section Molecular Pharmacology)
Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4752 | Submission Open
Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis
(This special issue belongs to the Section Molecular Nanoscience)
Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases
edited by Capercomorin S. Pitchumoni and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4629 | Submission Open
Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokine Networks in Inflammatory Skin Diseases
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4515 | Submission Open
Keywords: chronic inflammatory skin diseases; immunopathogenesis; inflammatory pathways; cytokines; molecular targets; psoriasis; atopic dermatitis; hidradenitis suppurativa; urticaria; lichen planus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4398 | Submission Open
Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights on Drug Discovery, Design, and Treatment
edited by Chih Kang Chiang
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4389 | Submission Open
Keywords: antibacterial drugs; antiviral drugs; antioxidant drugs; anti-inflammatory drugs; antibiotics; anticancer drugs; drug discovery; drug development; drug design; drug delivery; drug carriers; nanoparticles; molecular modeling; molecular mechanisms; crystallography; pharmacokinetics; molecular activity; inhibitors and antagonists
(This special issue belongs to the Section Molecular Pharmacology)
Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles submission deadline 20 Sep 2025 | 2 articles | Viewed by 4345 | Submission Open
Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target
(This special issue belongs to the Section Molecular Biophysics)
New Trends in Research on Cerebral Ischemia
edited by Hideaki Imai
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4343 | Submission Open
Keywords: white matter damage; ischemia; axon regeneration; intervention; cell transplantation; exosome therapy; stem cells; myelin integrity; neurological disorders; neural repair; cognitive impairments
(This special issue belongs to the Section Molecular Neurobiology)
Nutraceuticals for the Maintenance of Brain Health submission deadline 20 Sep 2025 | 4 articles | Viewed by 4220 | Submission Open
Keywords: vitamin; nutraceutics; brain; neuroinflammation; neurodegeneration; cognitive function
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Translational Research of Non-Small Cell Lung Cancer submission deadline 20 Sep 2025 | 1 articles | Viewed by 4122 | Submission Open
Keywords: non-small cell lung cancer; precision medicine; targeted therapy; resistance mechanisms; immunotherapy; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Molecular Basis of Vascular Pathology submission deadline 20 Sep 2025 | 4 articles | Viewed by 4113 | Submission Open
Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Wheat Genetics and Genomics: 3rd Edition
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 4037 | Submission Open
Keywords: wheat; genetics; molecular breeding; genome variation; multiomics
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Polymers and Polysaccharides in Delivery Systems
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3957 | Submission Open
Keywords: polysaccharides; synthetic polymers; drug delivery systems; enzyme drugs; gene delivery; targeted release; controlled drug delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
TRP Channel, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3917 | Submission Open
Keywords: TRP; TRPAnkyrin; TRPCanonical; TRPMelastatin; TRPPolycystin; TRPVanilloid
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Perspectives in Nanomedicine
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3896 | Submission Open
Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies
(This special issue belongs to the Section Molecular Nanoscience)
DNA and mRNA-Based Vaccines Against Infectious Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3861 | Submission Open
Keywords: mRNA vaccines; DNA vaccines; vaccine delivery; infectious disease; animal model
(This special issue belongs to the Section Molecular Immunology)
Musculoskeletal Diseases: Inflammation, Degeneration or Mechanical Stress
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3738 | Submission Open
Keywords: musculoskeletal diseases; inflammation; degeneration; mechanical stress; aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Analysis and Applications of Comparative and Functional Genomic on Horticultural Plants: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3644 | Submission Open
Keywords: horticultural plants; gene family; comparative genomics; genome evolution; gene function; gene expression; database construction; tool development
(This special issue belongs to the Section Molecular Genetics and Genomics)
C. elegans as a Disease Model: Molecular Perspectives: 2nd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 3633 | Submission Open
Keywords: Caenorhabditis elegans; model organism; disease model; neurodegenerative diseases; cancer model; ageing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Radioligand Therapy and Immunotherapy for Cancer Treatment submission deadline 20 Sep 2025 | 1 articles | Viewed by 3626 | Submission Open
Keywords: targeted radioligand therapy; immunotherapy; receptor targeting; tumor-specific antigens; immune checkpoint inhibitors; radiosensitization; tumor microenvironment; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Technical Developments and Recent Applications of Cellular Molecular Imaging
edited by Hanae Sato
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3577 | Submission Open
Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Mental Health and Disorders
edited by Eva Christina Schulte
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3545 | Submission Open
Keywords: molecular studies; mental health disorders; model systems; molecular epidemiology; omics   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified ChinesePRO Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3545 | Submission Open
Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome
(This special issue belongs to the Section Molecular Plant Sciences)
Chronic Liver Disease: From Pathophysiology to Treatment
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3495 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); type 2 diabetes (T2D)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanofibrous Biomaterials for Biomedicine and Medical Applications
edited by Jong-Young Kwak
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3479 | Submission Open
Keywords: nanofibers; biomaterials; 3D scaffold; 3D cell culture; tissue engineering; drug release
(This special issue belongs to the Section Materials Science)
High Fat Diet Metabolism and Diseases submission deadline 20 Sep 2025 | 4 articles | Viewed by 3425 | Submission Open
Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms of Oxidative Stress in Kidney Disease
edited by Stefanos Roumeliotis
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3422 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; hemodialysis; peritoneal dialysis; oxidative stress; pro-oxidants; inflammation; atherosclerosis; cardiovascular disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Electrochemotherapy
edited by Jurij Novickij, and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3422 | Submission Open
Keywords: electrochemotherapy; drug delivery; pulsed electric fields; cancer; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 3397 | Submission Open
Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Computational Methods for Studying the Effects of Radiation on Human Beings submission deadline 20 Sep 2025 | 2 articles | Viewed by 3396 | Submission Open
Keywords: DNA damage; biophysical models; DNA geometrical models; computational radiobiology; Monte Carlo simulations; ionizing radiation; heavy ions; DNA damage repair
(This special issue belongs to the Section Molecular Biophysics)
Stem Cells and Regenerative Medicine: In Vitro and In Vivo Studies—2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3367 | Submission Open
Keywords: stem cells; stem cell homing; stem cell tracking; regeneration; tissue injury; immunomodulation; biomaterials; tissue-on-a-chip; organoids; differentiation
(This special issue belongs to the Section Molecular Biology)
Probiotics, Prebiotics and Postbiotics: The Secrets of Promoting Microbial Balance in the Gut
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3355 | Submission Open
Keywords: probiotics; prebiotics; postbiotics; gut microbiota; gut epithelial integrity
(This special issue belongs to the Section Molecular Microbiology)
Physiological Functions and Pathological Effects of Microglia
edited by Hiroshi Nakanishi
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3348 | Submission Open
Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning
(This special issue belongs to the Section Molecular Neurobiology)
Anti-Inflammatory and Metabolic Effects of G Protein-Coupled Receptor Signaling
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3295 | Submission Open
Keywords: G protein-coupled receptors (GPCRs); seven transmembrane domain (7TM) receptors; metabotropic receptors; membrane receptors; GPCRs signaling; GPCRs signaling pathways; anti-inflammatory effects; inflammatory diseases; metabolic diseases; metabolic effects; anti-inflammatory treatment
(This special issue belongs to the Section Molecular Immunology)
New Cardiovascular Risk Factors: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 3290 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
Cellular Metabolism and Retinal Diseases: Unraveling Molecular Pathways and Therapeutic Targets submission deadline 20 Sep 2025 | 3 articles | Viewed by 3256 | Submission Open
Keywords: retina; metabolic dysfunction in retinal diseases; metabolism and retinal cell function; metabolism and oxidative stress; therapeutic targets; intracellular signaling; epigenetic modification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Targets and Immunotherapy for Autoimmune Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 3211 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells
(This special issue belongs to the Section Molecular Immunology)
Molecular Research Progress of Skin and Skin Diseases: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3208 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bilirubin: Health Challenges and Opportunities
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3202 | Submission Open
Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection
(This special issue belongs to the Section Molecular Biology)
Bioactive Natural Compounds: Protecting Plants and Promoting Human Health, 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 3196 | Submission Open
Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Quadruplex DNA and Its Ligands for Disease Treatment
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 3169 | Submission Open
Keywords: quadruplex; i-motif; transcriptional regulation; apoptosis; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Compounds with Added Value from Marine Algae for Biomedical Applications submission deadline 20 Sep 2025 | 1 articles | Viewed by 3156 | Submission Open
Keywords: algae bioactive compounds; algal biotechnology for biomedical purposes; algal-derived biomedical materials; algal-based drug delivery systems; alginate; carrageenan; fucoidan; marine polysaccharides; marine peptides; marine polyphenols; marine antioxidants; marine bioactive compounds; marine glycosaminoglycans; marine biopolymers and biomaterials; marine lipids; marine-derived pharmaceuticals; marine-derived cosmeceuticals; marine-derived nutraceuticals; marine algae added-value products; marine drugs discovery; marine natural products; marine-derived anti-inflammatory agents; marine antimicrobial compounds; marine-derived anticancer agents; marine neuroprotective compounds; marine-derived anti-aging compounds; marine-based regenerative medicine; phycobiliproteins; seaweed-based tissue engineering materials; seaweed-derived bioactive molecules; seaweed extracts; seaweed-based wound healing materials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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