Molecular and Translational Research of Non-Small Cell Lung Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 3764
Special Issue Editor
Interests: lung cancer; precision oncology; immunotherapy; rare cancer; head and neck cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lung cancer continues to be the leading cause of cancer death worldwide, and non-small cell lung cancer (NSCLC) represents the most prevalent form. Recent molecular research has significantly enhanced our understanding of the genetic alterations driving NSCLC development and progression. Key discoveries include the identification of driver mutations in genes such as EGFR, ALK, ROS1, RET, MET, KRAS, BRAF, HER2, and NTRK, which have unraveled the age of precision oncology and have led to the development of targeted therapies with improved patient outcomes and survival. Furthermore, the exploration of the tumor microenvironment and immune evasion mechanisms has paved the way for immune checkpoint inhibitors (ICIs), which have also helped to improve patient outcomes and have facilitated the presence of an increasing percentage of long-term survivors. Both targeted therapy and immunotherapy became part of standard treatment for patients with advanced disease, but now their role is rapidly expanding to earlier stages.
Thanks to this translational research, the prognosis of patients with NSCLC has significantly improved, but there is still much work to be carried out. Moreover, molecular research must continue to discover new driver mutations, resistance mechanisms, and biomarkers.
This Special Issue will encompass the latest advances in NSCLC precision medicine and targeted therapy, new potential driver molecular mechanisms, resistance molecular mechanisms to targeted therapy, molecular biomarkers of efficacy or toxicity to immunotherapy, and resistance molecular mechanisms to immunotherapy, both in advanced and early-stage disease.
Dr. Xabier Mielgo Rubio
Guest Editor
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Keywords
- non-small cell lung cancer
- precision medicine
- targeted therapy
- resistance mechanisms
- immunotherapy
- molecular biomarkers
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