ijms-logo

Journal Browser

Journal Browser

TRP Channel, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 3364

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA
Interests: potential use of resiniferatoxin (RTX) in chronic pain conditions; role of TRP channels in diabetic peripheral neuropathy; modulation of synaptic transmission by TRP channels; role of TRP channels in insulin and GLP-1 secretion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue follows the publication of the following edition on the topic “TRP Channels”.

The importance of transient receptor potential (TRP) channels was recognized by awarding the Nobel Prize in 2021 to David Julius and Ardem Patapoutian; both have dedicated substantial portions of their research careers to identifying and characterizing TRP channels, which are involved in sensory perception. Several other eminent scientists have made seminal contributions to our understanding of the intricate biological effects of TRP channels (TRPAnkyrin, TRPCanonical, TRPMelastatin, TRPPolycystin and TRPVanilloid), which mediate several biological functions. This Special Issue of International Journal of Molecular Sciences will be dedicated to highlighting the importance of TRP channels. This Special Issue provides a great opportunity for other scientists to express their views and impart their knowledge about TRP channels in health and disease to the larger scientific community to further the research in this field.

Prof. Dr. Louis Premkumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • TRP
  • TRPAnkyrin
  • TRPCanonical
  • TRPMelastatin
  • TRPPolycystin
  • TRPVanilloid

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

12 pages, 1733 KiB  
Article
Human Salivary Microbiota Diversity According to Ethnicity, Sex, TRPV1 Variants and Sensitivity to Capsaicin
by Elena Vinerbi, Gabriella Morini, Claudia Picozzi and Sergio Tofanelli
Int. J. Mol. Sci. 2024, 25(21), 11585; https://doi.org/10.3390/ijms252111585 - 29 Oct 2024
Viewed by 968
Abstract
The salivary microbiota of Italian and sub-Saharan African individuals was investigated using Nanopore sequencing technology (ONT: Oxford Nanopore Technologies). We detected variations in community composition in relation to endogenous (ethnicity, sex, and diplotypic variants of the TRPV1 gene) and exogenous (sensitivity to capsaicin) [...] Read more.
The salivary microbiota of Italian and sub-Saharan African individuals was investigated using Nanopore sequencing technology (ONT: Oxford Nanopore Technologies). We detected variations in community composition in relation to endogenous (ethnicity, sex, and diplotypic variants of the TRPV1 gene) and exogenous (sensitivity to capsaicin) factors. The results showed that Prevotella, Haemophilus, Neisseria, Streptococcus, Veillonella, and Rothia are the most abundant genera, in accordance with the literature. However, alpha diversity and frequency spectra differed significantly between DNA pools. The microbiota in African, male TRPV1 bb/ab diplotype and capsaicin low-sensitive DNA pools was more diverse than Italian, female TRPV1 aa diplotype and capsaicin high-sensitive DNA pools. Relative abundance differed at the phylum, genus, and species level. Full article
(This article belongs to the Special Issue TRP Channel, 2nd Edition)
Show Figures

Figure 1

13 pages, 2643 KiB  
Article
The Influence of Sex Steroid Hormone Fluctuations on Capsaicin-Induced Pain and TRPV1 Expression
by Edgardo Mota-Carrillo, Rebeca Juárez-Contreras, Ricardo González-Ramírez, Enoch Luis and Sara Luz Morales-Lázaro
Int. J. Mol. Sci. 2024, 25(15), 8040; https://doi.org/10.3390/ijms25158040 - 24 Jul 2024
Viewed by 1912
Abstract
Sexual dimorphism among mammals includes variations in the pain threshold. These differences are influenced by hormonal fluctuations in females during the estrous and menstrual cycles of rodents and humans, respectively. These physiological conditions display various phases, including proestrus and diestrus in rodents and [...] Read more.
Sexual dimorphism among mammals includes variations in the pain threshold. These differences are influenced by hormonal fluctuations in females during the estrous and menstrual cycles of rodents and humans, respectively. These physiological conditions display various phases, including proestrus and diestrus in rodents and follicular and luteal phases in humans, distinctly characterized by varying estrogen levels. In this study, we evaluated the capsaicin responses in male and female mice at different estrous cycle phases, using two murine acute pain models. Our findings indicate that the capsaicin-induced pain threshold was lower in the proestrus phase than in the other three phases in both pain assays. We also found that male mice exhibited a higher pain threshold than females in the proestrus phase, although it was similar to females in the other cycle phases. We also assessed the mRNA and protein levels of TRPV1 in the dorsal root and trigeminal ganglia of mice. Our results showed higher TRPV1 protein levels during proestrus compared to diestrus and male mice. Unexpectedly, we observed that the diestrus phase was associated with higher TRPV1 mRNA levels than those in both proestrus and male mice. These results underscore the hormonal influence on TRPV1 expression regulation and highlight the role of sex steroids in capsaicin-induced pain. Full article
(This article belongs to the Special Issue TRP Channel, 2nd Edition)
Show Figures

Figure 1

Back to TopTop