Molecular Genetics of Breast Cancer—Recent Progress

Dear Colleagues,

Each year, about 30% of all newly diagnosed cancers in women are breast cancers. Breast cancer is likely to be caused by the concurrent effects of different risk factors, including genetic risk factors. On the other hand, this disease could be characterized as an evolutionary process driven by the accumulation of somatic mutations and clonal selection. Therefore, the genetic profiling of breast cancer is essential to improve our understanding of the molecular etiology of this disease. In this field, next-generation sequencing (NGS) technology allowed for not only the identification and validation of novel susceptibility genes, but also the identification of molecular biomarkers and therapeutic targets.

Expanded knowledge on the molecular genetics of breast cancer is the first step leading to the early diagnosis, preventative strategies and treatment personalization. This molecular characterization is also particularly essential in understudied groups of breast cancer patients, such as men affected by the disease.

This Special Issue will focus on the molecular genetics of breast cancer for improved risk assessment and personalized therapy. We invite researchers to submit original research articles describing novel data, methods, collaborative initiatives and reviews related to these topics.

We look forward to receiving your contributions.

Dr. Virginia Valentini
Guest Editor

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• hereditary cancer
• female breast cancer
• male breast cancer
• molecular oncology
• cancer genetics
• NGS of gene panels
• transcriptomics
• genetic predisposition to breast cancer
• breast cancer risk
• tumor profiling
• predictive biomarkers
• personalized treatment