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Cytokine Networks in Inflammatory Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1668

Special Issue Editor


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Guest Editor
Laboratory of Experimental Immunology, Fondazione Luigi Maria Monti—Istituto Dermopatico dell’Immacolata (IDI)—IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
Interests: chronic inflammatory skin diseases; immunopathogenesis; inflammatory pathways; biomarkers; cytokines; biologics
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Special Issue Information

Dear Colleagues,

Chronic inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa arise from a complex interplay of genetic, environmental, and immunological factors. The prevalence of these conditions continues to rise, often accompanied by various comorbidities that significantly impair the quality of life. Central to their pathogenesis are cytokines, which mediate both immune and non-immune signaling pathways, thereby influencing skin homeostasis.

This Special Issue aims to provide a platform for dedicated researchers to share their latest findings on the mechanisms driving these skin conditions. The ultimate goal is to enhance our understanding of the intricate cytokine networks underlying these diseases and to provide evidence that could lead to the identification of potential molecules involved in their progression, thereby contributing to the development of innovative and targeted therapeutics.

Topics of interest for this Special Issue include, but are not limited to:

  • Molecular and immunological pathways involved in chronic inflammatory skin diseases.
  • Investigation of cytokine networks in skin inflammation using ex vivo, in vitro, or mouse model approaches.
  • Links between skin inflammation and systemic comorbidities.
  • Identification of molecular targets related to disease onset, severity, and treatment response.
  • Potential novel therapeutic targets.

Dr. Emanuele Scala
Guest Editor

Manuscript Submission Information

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Keywords

  • chronic inflammatory skin diseases
  • immunopathogenesis
  • inflammatory pathways
  • cytokines
  • molecular targets
  • psoriasis
  • atopic dermatitis
  • hidradenitis suppurativa
  • urticaria
  • lichen planus

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Published Papers (1 paper)

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Review

18 pages, 1130 KiB  
Review
Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response
by Daniel Simancas-Racines, Náthaly Mercedes Román-Galeano, Ludovica Verde, Giuseppe Annunziata, Marco Marchetti, Andri Matos, Martín Campuzano-Donoso, Claudia Reytor-González, Giovanna Muscogiuri, Luigi Barrea and Evelyn Frias-Toral
Int. J. Mol. Sci. 2025, 26(7), 2895; https://doi.org/10.3390/ijms26072895 - 22 Mar 2025
Viewed by 795
Abstract
Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate cytokine activity, providing a complementary [...] Read more.
Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate cytokine activity, providing a complementary approach to standard therapies. This narrative review examines the impact of various dietary strategies, including a Mediterranean diet, ketogenic diet, gluten-free diet, and fasting-mimicking diet, on cytokine profiles and clinical outcomes in psoriasis. Research insights reveal that dietary components such as omega-3 fatty acids, polyphenols, and short-chain fatty acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) and Signal Transducer and Activator of Transcription 3 (STAT3). Additionally, these dietary components promote anti-inflammatory effects mediated by gut microbiota. Clinical studies demonstrate significant reductions in psoriasis severity, improved quality of life, and modulation of key cytokines associated with disease activity. Despite these advancements, significant challenges persist in effectively integrating these findings into clinical practice. These challenges include variability in patient responses, adherence issues, and the need for robust biomarkers to monitor efficacy. Future directions emphasize the potential of personalized nutrition and precision medicine approaches to optimize dietary interventions tailored to individual cytokine profiles and genetic predispositions. Integrating these strategies into psoriasis care could transform treatment paradigms by simultaneously addressing both systemic inflammation and comorbid conditions. Full article
(This article belongs to the Special Issue Cytokine Networks in Inflammatory Skin Diseases)
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