ijms-logo

Journal Browser

Journal Browser

Stem Cells and Regenerative Medicine: In Vitro and In Vivo Studies—2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1888

Special Issue Editor


E-Mail Website
Guest Editor
Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
Interests: stem cell homing; nanoparticle assisted stem cell tracking; regenerative medicine ovarian follicologenesis in mammals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, stem cell therapy has become a very promising and advanced scientific research topic. Stem cells have the capability to self-renew and differentiate into several cell types, and are involved in physiological regeneration processes.

In the context of tissue injury, stem cells have gained worldwide attention because of their immense potential for immunomodulation and their therapeutic function. Stem cells can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and evade the immune system.

With so many stem cell replacement therapies undergoing clinical trials, there is a compelling need to understand the mechanisms behind a successful therapy, and one of the critical points of their discovery is to monitor and manage stem cell migration, proliferation, differentiation and organization in vitro as well as in vivo. In this context, the use of biomaterials to manipulate stem cells providing control of their behavior and homing has received great interest, becoming a pivotal step for the development of innovative stem cell transplantation solutions. 

This Special Issue aims to provide the latest updates on stem cells and their in vitro and in vivo applications in the regenerative medicine field, opening novel and advanced strategies for tissue-repairing processes and many other clinical applications.

Original articles, up-to-date review articles and commentaries addressing this topic are all welcome.

Dr. Alessia Peserico
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • stem cell homing
  • stem cell tracking
  • regeneration
  • tissue injury
  • immunomodulation
  • biomaterials
  • tissue-on-a-chip
  • organoids
  • differentiation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

20 pages, 1390 KiB  
Review
The Hidden Power of the Secretome: Therapeutic Potential on Wound Healing and Cell-Free Regenerative Medicine—A Systematic Review
by Jhon W. Prado-Yupanqui, Lourdes Ramírez-Orrego, Denny Cortez, Victor Juan Vera-Ponce, Stella M. Chenet, Juan R. Tejedo and Rafael Tapia-Limonchi
Int. J. Mol. Sci. 2025, 26(5), 1926; https://doi.org/10.3390/ijms26051926 - 23 Feb 2025
Viewed by 1557
Abstract
Various types of wounds represent a persistent healthcare burden that demands innovative and effective therapeutic solutions. Innovative approaches have emerged that focus on skin regeneration with minimal side effects. One such method is cell-free therapy that utilizes the secretome of human mesenchymal stem [...] Read more.
Various types of wounds represent a persistent healthcare burden that demands innovative and effective therapeutic solutions. Innovative approaches have emerged that focus on skin regeneration with minimal side effects. One such method is cell-free therapy that utilizes the secretome of human mesenchymal stem cells (hMSCs) as a promising alternative to traditional cell-based therapies, leveraging a complex mixture of bioactive molecules, including growth factors, cytokines, and extracellular vesicles, to accelerate tissue regeneration. This systematic review synthesizes the findings of 35 studies evaluating the impact of hMSC-derived secretomes on wound healing, with a focus on their regenerative, immunomodulatory, and angiogenic effects. The influence of MSC sources (adipose tissue, bone marrow, umbilical cord) and culture conditions on secretome composition and efficacy in the cutaneous wound healing process is examined, highlighting their therapeutic potential in regenerative medicine. This review also explores emerging preclinical and clinical applications, highlighting promising results, such as enhanced fibroblast proliferation, reduced inflammation, and improved extracellular matrix remodeling. In addition, advances in secretome-based biomaterials, including hydrogels and scaffolds, which optimize therapeutic delivery and efficacy are discussed. Despite the growing body of evidence supporting the safety and efficacy of secretomes, challenges remain regarding standardization, large-scale production, and clinical validation. This review highlights the potential of MSC-derived secretomes as a next-generation cell-free approach for wound healing and regenerative medicine. Full article
Show Figures

Figure 1

Back to TopTop