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Advances in Polymers and Polysaccharides in Delivery Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (20 September 2025) | Viewed by 6358

Special Issue Editor


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Guest Editor
”Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, No. 41A, 700487 Iasi, Romania
Interests: porous microparticles; graft polymerization; polysaccharides; zwitterionic polymers; smart polymers; drug delivery systems

Special Issue Information

Dear Colleagues,

Health is a top priority in today’s society. Although medicine has recorded many advances in recent years, it is clear that new directions are emerging in pharmaceutical research, namely the development of new treatments based on drugs with higher specificity, knowledge of the mechanisms by which new drugs act in the body, and the development of new types of drug formulations capable of increasing the treatment effectiveness.

Such formulations, such as systems with the controlled, sustained, or targeted release of various biologically active compounds (drugs, enzymes, microorganisms, cells, and food supplements), represent a field of science that progresses rapidly through the cumulative contributions of chemists, biochemists, pharmacologists, doctors, and nutritionists. The increased interest shown by the scientific community regarding polymer materials based on synthetic or polysaccharides represents a consequence of their remarkable characteristics as well as of the diverse necessities in the medical and pharmaceutical fields. For these reasons, this Special Issue, entitled “Advances in Polymers and Polysaccharides in Delivery Systems”, aims to offer researchers in the field the opportunity to share the latest achievements, insights, and experiences in the development and applications of polymeric delivery systems based on synthetic polymers and/or polysaccharides.

Dr. Stefania Racovita
Guest Editor

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Keywords

  • polysaccharides
  • synthetic polymers
  • drug delivery systems
  • enzyme drugs
  • gene delivery
  • targeted release
  • controlled drug delivery systems

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Published Papers (3 papers)

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Research

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17 pages, 6018 KB  
Article
Electrohydrodynamic Coating with Acyclovir PLGA Conjugate for Antiviral Functionalization of Medical Surfaces
by Tomasz Urbaniak and Witold Musiał
Int. J. Mol. Sci. 2025, 26(22), 10983; https://doi.org/10.3390/ijms262210983 - 13 Nov 2025
Viewed by 352
Abstract
Sexually transmitted infections, notably herpes simplex virus, remain significant global health concerns. Localized delivery systems that provide sustained antiviral activity at mucosal surfaces offer an attractive alternative to systemic therapies. In this study, we developed electrohydrodynamically deposited coatings utilizing a covalent acyclovir–poly (lactic-co-glycolic [...] Read more.
Sexually transmitted infections, notably herpes simplex virus, remain significant global health concerns. Localized delivery systems that provide sustained antiviral activity at mucosal surfaces offer an attractive alternative to systemic therapies. In this study, we developed electrohydrodynamically deposited coatings utilizing a covalent acyclovir–poly (lactic-co-glycolic acid) (ACV–PLGA) conjugate for potential antiviral functionalization of medical devices. The ACV–PLGA prodrug was synthesized via drug-initiated ring-opening polymerization, yielding a copolymer characterized by FTIR, NMR, GPC, and DSC, with controlled drug loading and biodegradable properties. Systematic optimization of electrospinning and electrospraying parameters enabled the fabrication of both particulate and nanofibrous coatings on silicone ring models. Morphological analysis by SEM demonstrated that polymer concentration, solvent composition, and applied voltage critically governed coating architecture, ranging from microparticle layers to uniform bead-free fibers. In vitro studies revealed morphology-dependent degradation profiles and sustained release of ACV over 56 days. This integrated approach combining covalent prodrug synthesis with tunable electrohydrodynamic deposition offers a promising strategy for long-acting local antiviral prophylaxis via functionalized medical surfaces. Full article
(This article belongs to the Special Issue Advances in Polymers and Polysaccharides in Delivery Systems)
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19 pages, 4354 KB  
Article
Studies on Sorption and Release of Doxycycline Hydrochloride from Zwitterionic Microparticles with Carboxybetaine Moieties
by Stefania Racovita, Marin-Aurel Trofin, Ana-Lavinia Vasiliu, Mihaela Avadanei, Diana Felicia Loghin, Marcela Mihai and Silvia Vasiliu
Int. J. Mol. Sci. 2024, 25(14), 7871; https://doi.org/10.3390/ijms25147871 - 18 Jul 2024
Cited by 1 | Viewed by 1484
Abstract
The aim of this study was to examine the use of zwitterionic microparticles as new and efficient macromolecular supports for the sorption of an antibiotic (doxycycline hydrochloride, DCH) from aqueous solution. The effect of relevant process parameters of sorption, like dosage of microparticles, [...] Read more.
The aim of this study was to examine the use of zwitterionic microparticles as new and efficient macromolecular supports for the sorption of an antibiotic (doxycycline hydrochloride, DCH) from aqueous solution. The effect of relevant process parameters of sorption, like dosage of microparticles, pH value, contact time, the initial concentration of drug and temperature, was evaluated to obtain the optimal experimental conditions. The sorption kinetics were investigated using Lagergren, Ho, Elovich and Weber–Morris models, respectively. The sorption efficiency was characterized by applying the Langmuir, Freundlich and Dubinin–Radushkevich isotherm models. The calculated thermodynamic parameters (ΔH, ΔS and ΔG) show that the sorption of doxycycline hydrochloride onto zwitterionic microparticles is endothermic, spontaneous and favorable at higher temperatures. The maximum identified sorption capacity value is 157.860 mg/g at 308 K. The Higuchi, Korsmeyer–Peppas, Baker–Lonsdale and Kopcha models are used to describe the release studies. In vitro release studies show that the release mechanism of doxycycline hydrochloride from zwitterionic microparticles is predominantly anomalous or non-Fickian diffusion. This study could provide the opportunity to expand the use of these new zwitterionic structures in medicine and water purification. Full article
(This article belongs to the Special Issue Advances in Polymers and Polysaccharides in Delivery Systems)
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Review

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18 pages, 1494 KB  
Review
Charge-Reversal Nano-Drug Delivery Systems in the Tumor Microenvironment: Mechanisms, Challenges, and Therapeutic Applications
by Yizhu Liang, Jiashuai Wu, Yutong Yan, Yunduan Wang, Hongtu Zhao, Xiaopeng Wang, Shijie Chang and Shuo Li
Int. J. Mol. Sci. 2024, 25(18), 9779; https://doi.org/10.3390/ijms25189779 - 10 Sep 2024
Cited by 16 | Viewed by 3876
Abstract
The charge-reversal nano-drug delivery system (CRNDDS) is a promising system for delivering chemotherapy drugs and has gained widespread application in cancer treatment. In this review, we summarize the recent advancements in CRNDDSs in terms of cancer treatment. We also delve into the charge-reversal [...] Read more.
The charge-reversal nano-drug delivery system (CRNDDS) is a promising system for delivering chemotherapy drugs and has gained widespread application in cancer treatment. In this review, we summarize the recent advancements in CRNDDSs in terms of cancer treatment. We also delve into the charge-reversal mechanism of the CRNDDSs, focusing on the acid-responsive, redox-responsive, and enzyme-responsive mechanisms. This study elucidates how these systems undergo charge transitions in response to specific microenvironmental stimuli commonly found in tumor tissues. Furthermore, this review explores the pivotal role of CRNDDSs in tumor diagnosis and treatment, and their potential limitations. By leveraging the unique physiological characteristics of tumors, such as the acidic pH, specific redox potential, and specific enzyme activity, these systems demonstrate enhanced accumulation and penetration at tumor sites, resulting in improved therapeutic efficacy and diagnostic accuracy. The implications of this review highlight the potential of charge-reversal drug delivery systems as a novel and targeted strategy for cancer therapy and diagnosis. Full article
(This article belongs to the Special Issue Advances in Polymers and Polysaccharides in Delivery Systems)
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