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DNA and mRNA-Based Vaccines Against Infectious Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 2736

Special Issue Editor


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Guest Editor
1. National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
2. The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
Interests: virology; ASFV; viral entry; emerging viruses; virus discovery; infectious diseases; coronavirus
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Special Issue Information

Dear Colleagues,

I am glad to announce a new Special Issue of IJMS, titled “DNA and mRNA-Based Vaccines against Infectious Diseases”. This Special Issue covers all relevant topics related to DNA and mRNA vaccines for infectious diseases in human and animals, ranging from the rational design to the development and production of preclinical and clinical applications. While human vaccines are of particular interest, manuscripts on animal vaccines are also welcome.

This Special Issue welcomes the submission of original research articles, short communications, and review articles with a focus on, but not limited to, the following:

  1. The development of DNA- and mRNA-based vaccines;
  2. The delivery of DNA- and mRNA-based vaccines;
  3. The mechanism involved in the elicited responses;
  4. Vaccine safety;
  5. Vaccines to prevent zoonotic transmission targeting the animal reservoir;
  6. Advances in DNA and mRNA vaccine formulation and adjuvantisation;
  7. Small animal model for vaccine evaluation.

Prof. Dr. Wentao Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mRNA vaccines
  • DNA vaccines
  • vaccine delivery
  • infectious disease
  • animal model

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Published Papers (1 paper)

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Review

35 pages, 524 KiB  
Review
Current Progress in the Development of mRNA Vaccines Against Bacterial Infections
by Alina Khlebnikova, Anna Kirshina, Natalia Zakharova, Roman Ivanov and Vasiliy Reshetnikov
Int. J. Mol. Sci. 2024, 25(23), 13139; https://doi.org/10.3390/ijms252313139 - 6 Dec 2024
Cited by 1 | Viewed by 2199
Abstract
Bacterial infections have accompanied humanity for centuries. The discovery of the first antibiotics and the subsequent golden era of their discovery temporarily shifted the balance in this confrontation to the side of humans. Nevertheless, the excessive and improper use of antibacterial drugs and [...] Read more.
Bacterial infections have accompanied humanity for centuries. The discovery of the first antibiotics and the subsequent golden era of their discovery temporarily shifted the balance in this confrontation to the side of humans. Nevertheless, the excessive and improper use of antibacterial drugs and the evolution of bacteria has gotten the better of humans again. Therefore, today, the search for new antibacterial drugs or the development of alternative approaches to the prevention and treatment of bacterial infections is relevant and topical again. Vaccination is one of the most effective strategies for the prevention of bacterial infections. The success of new-generation vaccines, such as mRNA vaccines, in the fight against viral infections has prompted many researchers to design mRNA vaccines against bacterial infections. Nevertheless, the biology of bacteria and their interactions with the host’s immunity are much more complex compared to viruses. In this review, we discuss structural features and key mechanisms of evasion of an immune response for nine species of bacterial pathogens against which mRNA vaccines have been developed and tested in animals. We focus on the results of experiments involving the application of mRNA vaccines against various bacterial pathogens in animal models and discuss possible options for improving the vaccines’ effectiveness. This is one of the first comprehensive reviews of the use of mRNA vaccines against bacterial infections in vivo to improve our knowledge. Full article
(This article belongs to the Special Issue DNA and mRNA-Based Vaccines Against Infectious Diseases)
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