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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Plant Genetic Research

edited by

Ming Chen

submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open

Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science

(This special issue belongs to the Section Molecular Plant Sciences)

Regulation of Gene Expression in Cell Differentiation

edited by

Iole Robuffo

submission deadline 31 Aug 2025 | Viewed by 87 | Submission Open

Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Genetics and Genomics of Silkworm

edited by

Min-Jin Han

submission deadline 31 Aug 2025 | Viewed by 83 | Submission Open

Keywords: silkworm genome; gene identification; comparative genomics; silkworm domestication; population genetics; functional genomics; insect immunity; genetic manipulation; silkworm breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open

Keywords: gliomas tumor microenvironment immune

(This special issue belongs to the Section Molecular Oncology)

New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies

edited by

Edyta Juszczuk-Kubiak

submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open

Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Molecular Research in Neuroimmunology

edited by Mireya Fernández-Fournier

submission deadline 31 Aug 2025 | Viewed by 75 | Submission Open

Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions

edited by

Andrius Sakalauskas

submission deadline 31 Aug 2025 | Viewed by 70 | Submission Open

Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Neurobiology of Headache and Migraine

edited by

Mamoru Shibata

submission deadline 31 Aug 2025 | Viewed by 68 | Submission Open

Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache

(This special issue belongs to the Section Molecular Neurobiology)

Multifunctional Antioxidants and Enzyme Inhibitors: Design, Synthesis and Mechanisms of Actions

edited by Choon Young Lee

submission deadline 31 Aug 2025 | Viewed by 64 | Submission Open

Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator

(This special issue belongs to the Section Macromolecules)

Recent Research in Nanoelectrochemistry

edited by

Ioan Baldea

submission deadline 31 Aug 2025 | Viewed by 55 | Submission Open

Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications

(This special issue belongs to the Section Materials Science)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by Paola Muggeo

submission deadline 31 Aug 2025 | Viewed by 45 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Computational, Structural and Spectroscopic Studies of Macromolecules

edited by Sanja Dolanski Babić

submission deadline 10 Sep 2025 | 2 articles | Viewed by 3655 | Submission Open

Keywords: macromolecules; structure DNA; effects on DNA; protein; carbohydrate; lipids; spectroscopic methods; FTIR; NMR; UV; CD; numerical methods

(This special issue belongs to the Section Macromolecules)

Preimplantation Genetic Testing in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 10 Sep 2025 | Viewed by 131 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Advances in the Pathophysiology and Treatment of Multiple Sclerosis and Related Disorders

edited by Natalia Szejko and

Sara Samadzadeh

submission deadline 10 Sep 2025 | Viewed by 127 | Submission Open

Keywords: multiple sclerosis; MS; central nervous system; pathophysiology; immunological system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Microbe Interaction Studies

edited by

Jie Zhang

submission deadline 10 Sep 2025 | Viewed by 78 | Submission Open

Keywords: plant-pathogen; plant microorganisms; microbial stress; plant diseases and pests; plant protection

(This special issue belongs to the Section Molecular Microbiology)

Advances in Molecular Research of Facial Adipose Compartments

edited by Marius Valeriu Hînganu

submission deadline 15 Sep 2025 | Viewed by 403 | Submission Open

Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing

(This special issue belongs to the Section Molecular Biology)

Regulatory Mechanism and Network of Abiotic Stress-Response in Plants 2.0

edited by

Yong-Hwan Moon

submission deadline 20 Sep 2025 | 17 articles | Viewed by 31379 | Submission Open

Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

From Molecular Insights to Novel Therapies: Neurological Diseases

edited by

Margarita Neganova

submission deadline 20 Sep 2025 | 15 articles | Viewed by 31030 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation

(This special issue belongs to the Section Molecular Neurobiology)

New Insights in Tumor Immunity

edited by

George Sharonov

submission deadline 20 Sep 2025 | 10 articles | Viewed by 29043 | Submission Open

Keywords: tumor immunity; tumor evolution; tumor antigens; immune surveillance; cancer immunoediting; tumor microenvironment; immunotherapies; immune checkpoints; tumor-specific lymphocytes

(This special issue belongs to the Section Molecular Immunology)

Skin, Autoimmunity and Inflammation 2.0

edited by

Annamaria Offidani

and

Federico Diotallevi

submission deadline 20 Sep 2025 | 3 articles | Viewed by 25893 | Submission Open

Keywords: skin diseases; skin immunology; skin autoimmunity; skin inflammation; inflammatory cytokines; biological therapies; immunotherapy; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Reproductive Endocrinology Research

edited by

Tsung-Hsien Lee

submission deadline 20 Sep 2025 | 8 articles | Viewed by 24990 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Novel Biosystems in Toxicology and Pharmacology

edited by

Ricardo Lagoa

Manuel Aureliano

and

Paula A. Videira

submission deadline 20 Sep 2025 | 4 articles | Viewed by 24566 | Submission Open

(This special issue belongs to the Section Molecular Biology)

Oxygen Variations, 2nd Edition

edited by

Costantino Balestra

Simona Mrakic-Sposta

and

Gerardo Bosco

submission deadline 20 Sep 2025 | 9 articles | Viewed by 24551 | Submission Open

Keywords: hypoxia; hyperoxia; normoxia; biochemichal response; integrative approach; normo-hypo-hyperbaric; molecular research; gene expression; adaptive reactions; extreme environments

(This special issue belongs to the Section Molecular Biology)

Recent Approaches for Wound Treatment—2nd Edition

edited by

César Viseras

Luana Perioli

and

Cinzia Pagano

submission deadline 20 Sep 2025 | 7 articles | Viewed by 21706 | Submission Open

(This special issue belongs to the Section Molecular Pharmacology)

Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition

edited by

Elia Ranzato

and

Simona Martinotti

submission deadline 20 Sep 2025 | 7 articles | Viewed by 19154 | Submission Open

Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Demyelinating Diseases: From Molecular Mechanisms to, Therapeutic Strategies—3rd Edition

edited by

Antonietta Bernardo

submission deadline 20 Sep 2025 | 5 articles | Viewed by 18158 | Submission Open

Keywords: biomarkers; cellular and molecular biology; cell differentiation; cellular metabolism; demyelinating diseases; drug developing strategies and drug repositioning; glia cell (oligodendrocytes; astrocytes and microglia); inflammation; lipid metabolism; mitochondria; myelination and remyelination nuclear receptors; nutraceuticals; signal transduction mechanisms; target identification

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research in Gut Microbiota–Gut–Brain Axis

edited by Ying Han

submission deadline 20 Sep 2025 | 3 articles | Viewed by 17950 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; short-chain fatty acid; immune pathway; vagus nerve; neuropsychiatric disorders; depression

(This special issue belongs to the Section Molecular Biology)

Effects of Bioactive Compounds in Oxidative Stress and Inflammation

edited by

Paul-Mihai Boarescu

and

Raluca Maria Pop

submission deadline 20 Sep 2025 | 7 articles | Viewed by 17286 | Submission Open

Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biomaterials for Dental and Orthopedic Applications

edited by

Lia Rimondini

and

Elena Varoni

submission deadline 20 Sep 2025 | 8 articles | Viewed by 16728 | Submission Open

(This special issue belongs to the Section Materials Science)

Advances in Spermatogenesis and Male Infertility

edited by Wanxi Yang

submission deadline 20 Sep 2025 | 9 articles | Viewed by 16565 | Submission Open

Keywords: male reproduction; hormone regulation; blood– testis barrier; male reproductive diseases; male infertility

(This special issue belongs to the Section Molecular Biology)

Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 20 Sep 2025 | 10 articles | Viewed by 16357 | Submission Open

Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Immunotherapy in Cancer: Molecular Basis and Novel Therapeutic Approaches

edited by Yonggu Lee

submission deadline 20 Sep 2025 | 7 articles | Viewed by 15630 | Submission Open

Keywords: cellular immunotherapy; adoptive immunotherapy; chimeric antigen receptor T-cell; epigenetic modulation; immunometabolism; microbiome; immune checkpoint inhibitor; cancer vaccine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases

edited by Maria Kokozidou

submission deadline 20 Sep 2025 | 5 articles | Viewed by 15577 | Submission Open

Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Update on Immunotherapies for Cancer

edited by

Peter Johannes Holst

submission deadline 20 Sep 2025 | 5 articles | Viewed by 15534 | Submission Open

Keywords: cell therapies; monoclonal antibodies; molecular adjuvants; oncolytic therapies; immunogenic; chemotherapy and radiotherapy; cancer vaccines; immunodominance; neoantigens; clinical trials; tumor immune microenvironment

(This special issue belongs to the Section Molecular Oncology)

Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition

edited by

Marianna Lauricella

and

Antonella D'Anneo

submission deadline 20 Sep 2025 | 4 articles | Viewed by 14148 | Submission Open

Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Bacteria

edited by

Giovanni Stelitano

submission deadline 20 Sep 2025 | 11 articles | Viewed by 13200 | Submission Open

Keywords: infections; bacteria; molecular biology; antimicrobials; bacterial enzymes; bioremediation

(This special issue belongs to the Section Molecular Microbiology)

Advances in the Molecular Diagnosis and Treatment of Pancreatic Cancer

edited by Steven T. Brower and Robert Pergolizzi

submission deadline 20 Sep 2025 | 5 articles | Viewed by 13104 | Submission Open

Keywords: pancreatic cancer; molecular diagnostics; biomarkers; oncogenes; epigenetics; genomic profiling; next-generation sequencing; liquid biopsy; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Breast Cancer: Pathophysiology and Treatment

edited by Costa Frangou

submission deadline 20 Sep 2025 | 6 articles | Viewed by 13075 | Submission Open

Keywords: breast; biomarker; early detection; immunotherapy; metastasis; microenvironment; outcomes; prognosis; relapse; treatment; tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: Genome Stability

edited by

Tae-Hong Kang

and

Lasse Lindahl

submission deadline 20 Sep 2025 | 5 articles | Viewed by 12842 | Submission Open

Keywords: genome stability; DNA damage response; DNA repair; DNA replication; DNA recombination; ATR/ATM pathway; GENOTOXINS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 3rd Edition

edited by

Zhidong Zhou

and

Alexandre Hiroaki Kihara

submission deadline 20 Sep 2025 | 4 articles | Viewed by 12595 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial

(This special issue belongs to the Section Molecular Neurobiology)

The Zebrafish Model in Animal and Human Health Research, 2nd Edition

edited by

Antonella Marino Gammazza

and

Marta Anna Szychlinska

submission deadline 20 Sep 2025 | 7 articles | Viewed by 12455 | Submission Open

Keywords: zebrafish; environmental toxicology; predictive toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Emerging Role of Neutrophils in Cancer: Molecular Aspects of Plasticity and Potential Therapeutic Targets

edited by

Deepika Awasthi

submission deadline 20 Sep 2025 | 4 articles | Viewed by 12058 | Submission Open

Keywords: neutrophils; cancer; tumor microenvironment; tumor-associated neutrophils; innate immunity

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology and Hormonal Regulation in Reproductive Processes

edited by

Martin Stimpfel

and Helena Ban Frangež

submission deadline 20 Sep 2025 | 4 articles | Viewed by 11583 | Submission Open

Keywords: infertility; reproduction; embryos; genetics; epigenetics; signaling pathway; sperm; oocyte

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Tau Pathobiology in Neurodegenerative Diseases: From Molecular Mechanisms to Therapeutic Advances

edited by

Valentina Latina

and

Giuseppina Amadoro

submission deadline 20 Sep 2025 | 3 articles | Viewed by 11030 | Submission Open

Keywords: Alzheimer’ s disease; tauopathies; tau neurotoxicity; cellular and animal models; signaling pathways; tau-targeting therapies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Translational Research on Bone Tumors, 2nd Edition

edited by

Michela Rossi

and

Andrea Del Fattore

submission deadline 20 Sep 2025 | 2 articles | Viewed by 10701 | Submission Open

Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Genetics of Human Reproduction

edited by

Jasenka Wagner

and

Borut Peterlin

submission deadline 20 Sep 2025 | 7 articles | Viewed by 10242 | Submission Open

Keywords: genetic; human reproduction; infertility; medically assisted reproduction; pregnancy complications; recurrent miscarriage

(This special issue belongs to the Section Molecular Genetics and Genomics)

102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology

edited by

Sumonto Mitra

submission deadline 20 Sep 2025 | 4 articles | Viewed by 9896 | Submission Open

Keywords: acetylcholine; physiological functions; pathological alterations; cholinergic pathways

(This special issue belongs to the Section Biochemistry)

Mitochondrial Dysfunction: A Metabolic, Cardiovascular, Neurodegenerative and Neuromuscular Issue: 2nd Edition

edited by

Stefano Doccini

Federica Morani

and Claudia Nesti

submission deadline 20 Sep 2025 | 4 articles | Viewed by 9804 | Submission Open

Keywords: bioenergetics; mitochondrial disorders; biomarkers; OxPhos complexes; mitochondrial DNA; aging; neurodegenerative diseases; cardiovascular diseases; metabolic diseases; therapies to counteract mitochondrial dysfunction TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Molecular Oncology in Brazil, 3rd Edition

edited by