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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Vaccine-Induced Immune Responses

edited by In Ohk Ouh

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1435 | Submission Open

Keywords: vaccine platforms; molecular mechanisms; innate immune sensing; adaptive immune responses; adjuvants and signaling pathways; antigen processing and presentation; immunological memory; systems immunology

(This special issue belongs to the Section Molecular Immunology)

Ion Channels in Health and Disease: From Physiology to Therapeutics

edited by

Yohan Seo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1396 | Submission Open

Keywords: ion channels; cellular homeostasis; chronic diseases; cancer; inflammation; therapeutic targets; drug resistance; channel modulators; translational medicine

(This special issue belongs to the Section Molecular Biology)

Metabolic Sensing and Adaptive Stress Responses in Aging and Chronic Disease

edited by Mark Slevin

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1365 | Submission Open

Keywords: metabolic sensing; aging and healthspan; exercise physiology; AMPK–mTOR signaling; autophagy and mitophagy; redox biology; mitochondrial quality control; cellular stress adaptation; chronic disease prevention; inflammaging

(This special issue belongs to the Section Molecular Biology)

Molecular Pathways Shaping Therapeutic Vulnerability in Leukaemia

edited by

Donia Moujalled

submission deadline 31 Aug 2026 | Viewed by 1322 | Submission Open

Keywords: leukaemia; acute myeloid leukaemia (AML); B-cell acute lymphoblastic leukaemia (B-ALL); pro-survival signalling; apoptosis; BH3 mimetics; drug resistance; combination therapy; functional drug screening; leukaemia mouse models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Determinants of Drug Response: From Molecular Mechanisms to Precision Therapy

edited by

Pedro Ayuso

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1196 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; drug response; drug metabolism; precision medicine; biomarkers; adverse drug reactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Animal Models for Neurobiological Diseases

edited by

Hiroki Toyoda

and

Jana Tchekalarova

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1193 | Submission Open

Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids

edited by

Yuancong Xu

and Peng Cao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1191 | Submission Open

Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular and Nanostructured Materials for Energy, Environmental, and Biomedical Applications

edited by

Balaji Murugan

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1139 | Submission Open

Keywords: advanced sustainable materials; molecular engineering; energy conversion and storage (supercapacitor, solar cells, and batteries); electrocatalysis and photocatalysis; environmental remediation; biomedical applications; bio/electrochemical sensing and bioelectronics; molecular surface structure and interface chemistry; in situ/operando spectroscopy

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1113 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Interplay Between Cytoskeletal Dynamics and Cell Signaling in Cancer

edited by

Aleksandra Glogowska

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1094 | Submission Open

Keywords: cytoskeleton; cancer; organelle function; golgi apparatus; endoplasmic reticulum; mitochondria; post-translational modification; tumor invasion; metastasis; chemoresistance; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Non-Coding RNAs in Human Research

edited by

Jesús Adrián López

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1087 | Submission Open

Keywords: microRNAs; lncRNAs; mRNA regulation; cell signaling pathways; RNA methylation; RNA phosphorylation; RNA deamidation; cell communication; chemoresistance; RNA inhibitors or activators

(This special issue belongs to the Section Molecular Genetics and Genomics)

Intermittent Hypoxia and Physiological Effects: Interplay Between Oxidative Stress, Inflammation, and Autonomic Dysregulation

edited by

Rodrigo L. Castillo

and

Esteban G. Figueroa

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1058 | Submission Open

Keywords: intermittent hypoxia; cardiovascular and pulmonary effects; oxidative stress; autonomic dysfunction; neuroinflammation; renal effects; animal models

(This special issue belongs to the Section Molecular Biology)

Brain–Organ Axis and Related Neurodegeneration

edited by

Nan-Shan Chang

and

Hieu-Huy Nguyen-Tran

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: brain–organ axis; microbiota–gut–brain axis; neurodegenerative diseases; neuroinflammation; signaling pathways and alterations; innate immunity

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics

edited by

Amal Kaddoumi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1021 | Submission Open

Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood–brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Immune Regulatory Mechanisms in the Pathogenesis of Autoimmunity

edited by

Elias Toubi

and

Vadasz Zahava

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: immune regulation; soluble regulatory molecules; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Advances in Vascular Function, Senescence and Remodeling: A New Direction for Therapeutic Approach to Prevent CVDs

edited by

Gautham Yepuri

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1002 | Submission Open

Keywords: vascular dysfunction; senescence; endothelial cells; small molecules; anti-aging; cardiovascular diseases; sudden death

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Endothelial Dysfunction, Fifth Edition

edited by

Catherine Davis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 997 | Submission Open

Keywords: vascular permeability; atherosclerosis; blood–brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Aug 2026 | 1 articles | Viewed by 994 | Submission Open

Keywords: placental barrier; maternal–fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Targets and Toxic Interactomes of Pathogenic Proteins in Neurodegeneration

edited by

Kohji Fukunaga

and Ichiro Kawahata

submission deadline 31 Aug 2026 | 1 articles | Viewed by 988 | Submission Open

Keywords: neurodegenerative diseases; tau protein; TDP-43; α-synuclein; endoplasmic reticulum stress; mitochondrial toxicity; liquid–liquid phase separation; toxic Interactomes

(This special issue belongs to the Section Molecular Neurobiology)

Nanoparticle–Protein Interactions: Therapeutic Approaches and Supramolecular Chemistry

edited by Rodrigo da Silva Ferreira

submission deadline 31 Aug 2026 | 1 articles | Viewed by 978 | Submission Open

Keywords: nanoparticle–protein interactions; nanomedicine; supramolecular chemistry; surface functionalization; protein corona; nanocarriers; biointerfaces; molecular recognition; therapeutic nanomaterials; computational nano–bio modelling

(This special issue belongs to the Section Molecular Nanoscience)

Nanobiomaterials for Medical Research: From Molecular Mechanisms to Clinical Translation

edited by

Carmen Curutiu

Alina Maria Holban

and

Florin Iordache

submission deadline 31 Aug 2026 | 1 articles | Viewed by 929 | Submission Open

Keywords: nanomaterials; biopolymers; medical research; chronic diseases; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Global Challenges in Fungal Diseases: Pathogenesis, Host Interactions, and Novel Antifungal Approaches

edited by Samir Jawhara

submission deadline 31 Aug 2026 | 1 articles | Viewed by 928 | Submission Open

Keywords: Candida species; Aspergillus spp.; Mucorales; Fusarium spp.; multidrug-resistant fungi; immune response; opportunistic mycoses; host–pathogen interactions fungal cell wall glycans anti-fungal drugs

(This special issue belongs to the Section Molecular Microbiology)

Molecular Immunopathogenesis and Treatment of Hematological Malignancies

edited by Tatsuro Jo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 923 | Submission Open

Keywords: hematological malignancies; molecular pathogenesis; tumor microenvironment; immunogenomics; clonal evolution; biomarkers; immune monitoring; T-cell receptor repertoire; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Advanced Optical Imaging and Spectroscopy: Bridging Technical Innovation and Molecular Insights in Biomedicine

edited by Kanwarpal Singh and Sharma Gargi

submission deadline 31 Aug 2026 | 2 articles | Viewed by 913 | Submission Open

Keywords: optical imaging; biomedical spectroscopy; multimodal imaging; molecular imaging; label-free diagnostics; photonic instrumentation; in vivo imaging; computational imaging

(This special issue belongs to the Section Molecular Biophysics)

Traditional and Emerging Molecular Approaches for Enhancing Genetic Gain in Plant Breeding

edited by

Fozia Ghouri

submission deadline 31 Aug 2026 | 2 articles | Viewed by 907 | Submission Open

Keywords: genome editing and engineering; marker-assisted selection; molecular mechanisms of stress adaptation; epigenetics and gene regulation; speed breeding and molecular markers; artificial intelligence; omics and biotechnological technologies

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Metabolic Bone Disorders

edited by

Harish K. Datta

submission deadline 31 Aug 2026 | 1 articles | Viewed by 902 | Submission Open

Keywords: metabolic bone disease; bone cells; rare diseases; genetics; molecular biology; skeletal development disorders

(This special issue belongs to the Section Molecular Biology)

Programmed Cell Death and Oxidative Stress: 4th Edition

edited by

Takuya Noguchi

submission deadline 31 Aug 2026 | 2 articles | Viewed by 900 | Submission Open

Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress

(This special issue belongs to the Section Biochemistry)

Recent Research in Cerebellar Development and Disease

edited by Maryam Rahimi-Balaei

submission deadline 31 Aug 2026 | 1 articles | Viewed by 881 | Submission Open

Keywords: cerebellar development; cerebellum; neural development; neurogenesis; neuronal migration; cerebellar malformations

(This special issue belongs to the Section Molecular Neurobiology)

Non-Coding RNAs and Post-Transcriptional Modifications in Cancer

edited by

Christos K. Kontos

submission deadline 31 Aug 2026 | 1 articles | Viewed by 873 | Submission Open

Keywords: solid tumors; hematological malignancies; long non-coding RNAs; circular RNAs; short non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets in Heart Failure

edited by Celestino Sardu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 869 | Submission Open

Keywords: heart failure; molecular mechanisms; ventricular remodeling; biomarkers; myocardial fibrosis; inflammation; oxidative stress; non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multi-Omics Research in Oncology

edited by

Wenchao Gu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: multi-omics; cancer genomics; transcriptomics; single-cell sequencing; spatial omics; machine learning; artificial intelligence; biomarker discovery

(This special issue belongs to the Section Molecular Oncology)

Advances in Plant Bioactive Compounds

edited by

Tarek Alshaal

submission deadline 31 Aug 2026 | 1 articles | Viewed by 807 | Submission Open

Keywords: plant bioactive compounds; phytochemicals; polyphenols; flavonoids; terpenoids; alkaloids; antioxidants; anti-inflammatory activity; molecular mechanisms; signaling pathways; gut microbiota; bioavailability; nutraceuticals; functional foods; phytochemistry; omics technologies; structure–activity relationship

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Atlas of Cardiac Development and Diseases

edited by

Hector Alejandro Cabrera-Fuentes

submission deadline 31 Aug 2026 | Viewed by 802 | Submission Open

Keywords: cardiac development; molecular atlas; cardiovascular disease; single cell and spatial omics; multi omics integration; gene regulatory networks; cardiac remodeling; heart failure; systems biology; artificial intelligence in cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds and Molecular Mechanisms in Health and Disease

edited by

Lucas Fornari Laurindo

and

Maria Angélica Miglino

submission deadline 31 Aug 2026 | Viewed by 774 | Submission Open

Keywords: bioactive compounds; molecular mechanisms; metabolic regulation; inflammation; oxidative stress; signaling pathways; chronic diseases; translational research; systems biology; disease prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bacterial–Host Interactions: Molecular Mechanisms Governing Mutualism and Pathogenicity

edited by

Charles Viau

submission deadline 31 Aug 2026 | 1 articles | Viewed by 690 | Submission Open

Keywords: bacterial–host interactions; bacteria; host; host–microbe

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Hormone/Receptor System in Human Diseases

edited by Elena Zocchi,

Sonia Spinelli

and

Laura Sturla

submission deadline 31 Aug 2026 | 1 articles | Viewed by 688 | Submission Open

Keywords: hormone; receptor; energy metabolism; mitochondria

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations

edited by

José Luna-Muñoz

and Alejandra Morlett-Paredes

submission deadline 31 Aug 2026 | Viewed by 686 | Submission Open

Keywords: tauopathies and protein aggregation; amyloid beta and neurotoxicity; emerging proteins in neurodegeneration; molecular and morphological biomarkers; innovative therapies and experimental targets; artificial intelligence and neuropathological analysis

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Metabolic and Signaling Dysregulations: From Molecular Mechanisms to Disease Pathogenesis

edited by Gergana M. Deevska

submission deadline 31 Aug 2026 | 2 articles | Viewed by 685 | Submission Open

Keywords: lipid signaling; lipid metabolism; lipid homeostasis; metabolic dysregulation; signal transduction; disease pathogenesis

(This special issue belongs to the Section Molecular Biology)

Advanced Molecular Research on Kidney Diseases

edited by Joan Torras and Laura Martinez Valenzuela

submission deadline 31 Aug 2026 | 2 articles | Viewed by 679 | Submission Open

Keywords: renal genomics; molecular; proteomics and metabolomics; cellular mechanisms and biomarkers; therapeutic innovations; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolomics Research of Environmental Stress in Plants

edited by

Manish Kumar Patel

and Sonika Pandey

submission deadline 31 Aug 2026 | Viewed by 670 | Submission Open

Keywords: agricultural applications of primary and secondary metabolite;; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Products and Synthetic Molecules: Development of Novel Anticancer Drugs

edited by Vinícius D’Ávila Bitencourt Pascoal

submission deadline 31 Aug 2026 | Viewed by 654 | Submission Open

Keywords: anticancer drugs; natural products; synthetic molecules; bioactive compounds; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Artificial Intelligence in Drug Design: Molecular Aspects

edited by

Dorota Latek

submission deadline 31 Aug 2026 | 1 articles | Viewed by 650 | Submission Open

Keywords: artificial intelligence; machine learning; drug design; medical imaging; apoptosis; metastasis; anticancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Effects of Diet and Nutrients on Prediabetes/Diabetes

edited by Flavio Francini and Luis Flores

submission deadline 31 Aug 2026 | Viewed by 636 | Submission Open

Keywords: diabetes; prediabetes; insulin resistance; hyperglycemia; diet; dietary patterns; nutrients; molecular biology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cardiovascular and Metabolic Sequelae of Peripheral Artery Disease: From Mechanisms to Therapeutic Targets

edited by

Tzong-Shyuan Lee

submission deadline 31 Aug 2026 | 1 articles | Viewed by 631 | Submission Open

Keywords: peripheral artery disease (PAD); cardiometabolic complications; molecular mechanisms; endothelial dysfunction; interorgan crosstalk

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phytohormones in Plant Responses to Abiotic Stress

edited by

Marzena Kurowska

submission deadline 31 Aug 2026 | 1 articles | Viewed by 627 | Submission Open

Keywords: phytohormones; hormone signaling; abiotic stress responses; signaling crosstalk; transcriptional regulation; gene expression; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targets in Reproductive Diseases

edited by

Changwon Yang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 623 | Submission Open

Keywords: reproductive diseases; endometriosis; polycystic ovary syndrome; infertility-related disorders; pregnancy complications; reproductive system cancers; reproductive medicine; precise diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibacterial Drug Discovery and Molecular Mechanisms of Antimicrobial Resistance

edited by

Eduardo Martins De Sousa

submission deadline 31 Aug 2026 | 1 articles | Viewed by 582 | Submission Open

Keywords: antibacterial drug discovery; molecular mechanisms of resistance; molecular microbiology; antibiotic targets; structure–function relationships; bacterial efflux pumps; drug-inactivating enzymes; bacterial biofilms

(This special issue belongs to the Section Molecular Microbiology)

Probiotics, Prebiotics, Synbiotics, and Gut Microbial Modulation in Intestinal Health and Disease

edited by Koji Yamamoto

submission deadline 31 Aug 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: gut microbiota; probiotics; prebiotics; synbiotics; inter-organ network; intestinal barrier; microbial metabolites; immunoregulation; multi-omics; inflammatory bowel disease; microbiome-based therapy

(This special issue belongs to the Section Molecular Microbiology)

Medicinal Plants: Molecular Dissection of Active Compounds

edited by

Moxian Chen

and

Abazar Ghorbani

submission deadline 31 Aug 2026 | 1 articles | Viewed by 545 | Submission Open

Keywords: medicinal plants; active compounds; secondary metabolites; biosynthetic pathways; metabolic regulation; terpenoids; flavonoids; multi-omics; metabolic engineering; bioactivity

(This special issue belongs to the Section Molecular Plant Sciences)

Periodontitis: From Cellular Mechanism to Therapy

edited by Mahmoud Elashiry

submission deadline 31 Aug 2026 | Viewed by 543 | Submission Open

Keywords: periodontitis; inflammatory bone disease; host–microbe interactions; innate and adaptive immunity; osteoimmunology; cellular signaling; immune dysregulation; tissue destruction; translational therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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