Molecular Immunopathogenesis and Treatment of Hematological Malignancies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 615
Editor
Interests: lymphoma; hematology; multiple myeloma; hematological malignancies; chemotherapy; hematologic diseases; clinical hematology; myelodysplastic syndromes; leukemia; acute myeloid leukemia
Special Issue Information
Dear Colleagues,
Hematological malignancies arise through complex interactions between genetic/epigenetic alterations, clonal evolution and dysregulated immune surveillance within specialized hematopoietic and lymphoid microenvironments. Recent advances in molecular diagnostics (e.g., targeted sequencing, fusion detection, copy-number profiling and measurable residual disease assessment) have refined disease classification and risk stratification, while simultaneously uncovering actionable vulnerabilities. In parallel, progress in immunology and immune monitoring has revealed how immune cell composition, activation/exhaustion states, antigen presentation and immune escape shape clinical phenotypes and therapeutic responses. These insights are particularly relevant in the era of precision medicine, where targeted agents and immunotherapies (including monoclonal antibodies, bispecific antibodies and cellular therapies) have not only transformed treatment landscapes but also introduced new mechanisms of resistance and toxicity.
This Special Issue aims to provide a focused platform for original research and state-of-the-art reviews that illuminate molecular immunopathogenesis and translate mechanistic insights into improved diagnostics, biomarker-driven stratification and therapeutic strategies for hematological malignancies.
Dr. Tatsuro Jo
Guest Editor
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Keywords
- hematological malignancies
- molecular pathogenesis
- tumor microenvironment
- immunogenomics
- clonal evolution
- biomarkers
- immune monitoring
- T-cell receptor repertoire
- targeted therapy
- immunotherapy
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