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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phytochemicals for Diabetes

edited by

Cosmin Mihai Vesa

submission deadline 30 Apr 2026 | Viewed by 212 | Submission Open

Keywords: phytochemicals; diabetes mellitus; insulin resistance; oxidative stress; inflammation; plant extracts; polyphenols; flavonoids; nutraceuticals; diabetic complications

(This special issue belongs to the Section Molecular Pharmacology)

Transition-Metal-Based Nanoparticles: Synthesis, Properties and Applications

edited by Ramin Yousefi and

Sasan Rezaee

submission deadline 30 Apr 2026 | Viewed by 211 | Submission Open

Keywords: transition metal nanoparticles; synthesis; structure– property relationship; catalysis; photocatalysis; energy storage and conversion; biomedical applications; drug delivery; environmental remediation; plasmonics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Targeted Therapy and Epigenetic Advances in Cancer

edited by Qing Sheng Mi and

Li Zhou

submission deadline 30 Apr 2026 | Viewed by 204 | Submission Open

Keywords: cancer; epigenetic; therapeutic targets; chromatin; DNA methylation; histone modification; noncoding RNA; histone variants

(This special issue belongs to the Section Molecular Oncology)

Genomic, Transcriptomic, and Epigenetic Approaches in Fish Research

edited by

Feng Liu

submission deadline 30 Apr 2026 | Viewed by 181 | Submission Open

Keywords: fish biology; omics technologies; genomics and transcriptomics; environmental adaptation; aquaculture traits

(This special issue belongs to the Section Molecular Biology)

Focus on Heterocyclic Compounds and Their Various Applications

edited by

Georgia Zissimou

submission deadline 30 Apr 2026 | Viewed by 180 | Submission Open

Keywords: heterocyclic compounds; heterocyclic organic synthesis; medicinal heterocycles; bioactive heterocycles; heterocycles in materials sciences

(This special issue belongs to the Section Biochemistry)

Genome Editing in Disease Research: Applications in Animal Models and Organoids

edited by

Timofey S. Rozhdestvensky

submission deadline 30 Apr 2026 | Viewed by 176 | Submission Open

Keywords: genome editing; CRISPR/Cas; disease modeling; functional genomics; organoids

(This special issue belongs to the Section Molecular Biology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 30 Apr 2026 | Viewed by 171 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

The Impact of Oxidative Stress on Male and Female Germ Cells: From Redox Biology to Photon Emission

edited by

József Bódis

submission deadline 30 Apr 2026 | Viewed by 169 | Submission Open

Keywords: oxidative stress; germ cells; fertility; redox signaling; mitochondrial dynamics; DNA damage; photonic communication; ultra-weak photon emission; quantum biology; reproductive health

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Nutrient Uptake and Utilization in Plants

edited by

Stella Karydogianni

submission deadline 30 Apr 2026 | Viewed by 164 | Submission Open

Keywords: agriculture and crop improvement; molecular and cellular mechanisms; nitrogen; nutrient efficiency; protein

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Neurorepair and Regeneration

edited by

Andrei Gresita

and Tiago Santos

submission deadline 30 Apr 2026 | Viewed by 159 | Submission Open

Keywords: neurorepair; regeneration; neuroplasticity; cellular reprogramming; biomaterials; stroke; spinal cord injury; traumatic brain injury; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Hepatic Amino Acid Catabolism

edited by Carolina Conter

submission deadline 30 Apr 2026 | Viewed by 157 | Submission Open

Keywords: amino acid catabolism; essential amino acids; non-essential amino acids; liver metabolism; urea cycle; gluconeogenesis; lipid metabolism; nutritional regulation; mTOR signaling; metabolic diseases

(This special issue belongs to the Section Biochemistry)

Natural Compounds: Impact on Health and Disease

edited by

Jaehoon Bae

submission deadline 30 Apr 2026 | Viewed by 148 | Submission Open

Keywords: natural compounds; bioactive molecules; disease prevention; phytochemicals; functional food; molecular mechanisms; therapeutic potential; oxidative stress; immune modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Mechanism in Amyotrophic Lateral Sclerosis

edited by Nilo Riva

submission deadline 30 Apr 2026 | Viewed by 144 | Submission Open

Keywords: amyotrophic lateral sclerosis; motor neuron vulnerability; TDP-43; axonal degeneration; proteinopathy; stress granules; C9orf72; SOD1; RNA metabolism; FTD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 30 Apr 2026 | Viewed by 141 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 30 Apr 2026 | Viewed by 139 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Next-Generation CRISPR and Gene Editing Tools

edited by

Oscar Pérez-Leal

submission deadline 30 Apr 2026 | Viewed by 138 | Submission Open

Keywords: CRISPR engineering; miniaturized CRISPR; gene editing delivery; prime editing; base editing; epigenome editing; single-cell CRISPR

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research on Stress Signaling in Embryonic Development

edited by

Poongodi Geetha-Loganathan

and Norihisa Higashihori

submission deadline 30 Apr 2026 | Viewed by 136 | Submission Open

Keywords: stress signaling; embryonic development; morphogenesis; signal transduction; teratogenesis

(This special issue belongs to the Section Molecular Biology)

Dysfunctional Neural Circuits and Impairments in Brain Function, 2nd Edition

edited by

Takashi Tominaga

and

Ichiro Takashima

submission deadline 30 Apr 2026 | Viewed by 134 | Submission Open

Keywords: neural circuits; dysfunctional circuits; neuropsychiatric disorders; optical recording; voltage-sensitive dyes; genetically encoded optical indicators; local brain activity; whole-brain activity; cognitive impairments; behavioral test

(This special issue belongs to the Section Molecular Neurobiology)

The Zebrafish Model in Animal and Human Health Research, 3rd Edition

edited by

Marta Anna Szychlinska

and Federica Scalia

submission deadline 30 Apr 2026 | Viewed by 128 | Submission Open

Keywords: zebrafish; environmental toxicology; predictive toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Signaling Pathways in Inflammation and Diseases

edited by

Francesca Oppedisano

and

Cristina Algieri

submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open

Keywords: mitochondria; cell metabolism; inflammatory mitochondrial signalling; metabolic pathways; mitochondrial dysfunction; mtDNA; cGAS-STING pathway; NLRP3 inflammasome; human pathology

(This special issue belongs to the Section Biochemistry)

Insights into Immunodeficiency and Immunotherapy in Multiple Myeloma

edited by

Marjorie Pick

and

Eyal Lebel

submission deadline 30 Apr 2026 | Viewed by 123 | Submission Open

Keywords: multiple myeloma; plasma cells; monoclonality; immunodeficient

(This special issue belongs to the Section Molecular Immunology)

Mitochondria: Not Just Powerhouse of the Cell

edited by

Kailash Chandra Mangalhara

submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open

Keywords: mitochondrial nucleic acid; mitonuclear communication; mito-ER communication; mito-lysosome communication; mitochondria in cancer; mitochondrial metabolic disorders; mitochondria in inflammation

(This special issue belongs to the Section Molecular Biology)

Peptides in Healthcare and Beyond: Emerging Roles in Skincare, Nutrition, Medicine, and Animal Health

edited by

Jiazhong Li

and Lijing Fang

submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open

Keywords: peptides; efficacy; healthcare; skincare; nutrition; medicine; animal health

(This special issue belongs to the Section Biochemistry)

New Insights into the Structure and Function of Nuclear Receptors

edited by

Elza Fonseca

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: transcription factors; endocrine disorders; ligands; xenobiotics; pharmacology; modelling; drug design; evolution; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Bone Health: From Molecular Mechanisms to Therapeutics

edited by

Farasat Zaman

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: bone growth; chondrocytes; osteoporosis; fractures; inflammation; cancer; nutrition; stress; biomechanics; biotechnology; bioengineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cariovascular Diseases: From Molecular Mechanisms to Therapeutics

edited by

Paul Quax

submission deadline 30 Apr 2026 | Viewed by 117 | Submission Open

Keywords: yocardial infarction and cardiac regeneration; microvasculature in cardiovascular health and disease; gender specific aspects of cardiovascular disease; heart failure; aneurysm formation and dissection; vascular remodeling (restenosis; atherosclerosis; angioegenesis); valve failure; replacement or regeneration; atherosclerosis; imaging; new therapeutic options including non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles—New Findings on the Block in Liquid Biopsy

edited by Christa Nöhammer

submission deadline 30 Apr 2026 | Viewed by 117 | Submission Open

Keywords: extracellular vesicles; biological fluids; liquid biopsy; multi-omics; biomarkers; EV technologies

(This special issue belongs to the Section Molecular Biology)

Gene Therapy for Ocular Diseases: Mechanisms, Advances and Therapeutic Applications

edited by Jiang-Hui Wang

submission deadline 30 Apr 2026 | Viewed by 114 | Submission Open

Keywords: AAV; capsid engineering; gene therapy; retinal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Impact of Exercise on Molecular and Cellular Processes in the CNS

edited by

Philippe De Deurwaerdere

and Hélène Gréa

submission deadline 30 Apr 2026 | Viewed by 113 | Submission Open

Keywords: physical exercise; plasticity; neurotransmission; metabolism; neuroinflammation; glia; epigenetic; CNS disease; animal models; humans

(This special issue belongs to the Section Molecular Biology)

Novel Advances in Ataxia-Telangiectasia

edited by David Coman

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: ataxia-telangiectasia; ATM; metabolism; mitochondrial dysfunction; DNA repair; natural history; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biomarkers in Mood Disorders

edited by Lionella Palego and

Valerio Dell’Oste

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: mood disorders; etiopathogenesis; genetics/epigenetics; RNA analyses; neuroendocrinology; inflammation; molecular markers

(This special issue belongs to the Section Molecular Neurobiology)

Gut Microbiota-Derived Metabolites in Human Health and Disease

edited by Zeneng Wang

submission deadline 30 Apr 2026 | Viewed by 109 | Submission Open

Keywords: microbiome; microbiota; gut; metabolomics; health; disease; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Emerging Topics in Polymeric Nanoparticles

edited by

Andrei Honciuc

and

Mirela Honciuc

submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open

Keywords: polymeric nanoparticles; nanostructured materials; functional polymers; Janus particles; self-assembly; drug delivery; environmental remediation; microplastics; biodegradability; nanomedicine; green synthesis; adsorbents; life cycle assessment; surface functionalization; smart materials; biocompatibility; environmental impact; bioaccumulation; responsive polymers; hybrid nanomaterials

(This special issue belongs to the Section Macromolecules)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 30 Apr 2026 | Viewed by 103 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Dopamine Neurotransmission in Schizophrenia

edited by

Mirian Akemi Furuie Hayashi

submission deadline 30 Apr 2026 | Viewed by 101 | Submission Open

Keywords: schizophrenia; dopamine; dopaminergic system; neurotransmission; psychosis; pathophysiology; molecular psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Decoding the Pediatric Brain Tumor Microenvironment: A Molecular Perspective

edited by

Samuele Tardito

submission deadline 30 Apr 2026 | Viewed by 100 | Submission Open

Keywords: pediatric brain tumor; precision immunotherapy; pediatric neuro-oncology; tumor microenvironment (TME); single-cell RNA sequencing; whole transcriptomics; mass spectrometry-based proteomics; mass cytometry; cellular and molecular architecture; organoid

(This special issue belongs to the Section Molecular Oncology)

Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

edited by

Jarosław Nuszkiewicz

and

Alina Woźniak

submission deadline 30 Apr 2026 | Viewed by 100 | Submission Open

Keywords: oxidative stress; redox homeostasis; reactive oxygen species (ROS); redox signaling; antioxidants and defense mechanisms; metabolic regulation; inflammation and redox imbalance; mitochondrial dysfunction; biomarkers of oxidative stress; therapeutic redox modulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 30 Apr 2026 | Viewed by 99 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Molecular, Genetic and Genomic Insights into Marine Organisms: From Mechanisms to Ecology

edited by Yaron Tikochinski

submission deadline 30 Apr 2026 | Viewed by 99 | Submission Open

Keywords: marine genomics; molecular ecology; population genetics; transcriptomics; conservation genomics; eDNA; functional genomics; environmental stress; phylogeography; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 30 Apr 2026 | Viewed by 99 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Multi-Target and Synergistic Therapeutic Strategies in Modern Drug Discovery

edited by

Vincenzo Piccolo

submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open

Keywords: multi-target and synergistic therapeutic strategies; drug design; combination therapy; polypharmacology; drug re-purposing

(This special issue belongs to the Section Molecular Pharmacology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

Regulatory Mechanism and Network of Abiotic Stress-Response in Plants: 3rd Edition

edited by

Yong-Hwan Moon

submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open

Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

Microplastics, Gut Microbiome and Human Health

edited by

Ying Zhang

submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open

Keywords: microplastics; gut microbiome; dysbiosis; intestinal barrier; immunotoxicity; metabolic inflammation; na-noplastics; molecular mechanisms

Tumor Organoids in Translational Cancer Research: Mechanisms and Applications

edited by Yong-Jun Kwon

submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open

Keywords: tumor organoids; tumor heterogeneity; multi-omics profiling; drug resistance; tumor microenvironment; patient-derived models; organoid biobank; high-throughput drug screening; personalized therapy; translational research

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms, Epigenetics and Therapeutics in Liver Cirrhosis

edited by Ana Soledad Sandoval-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open

Keywords: liver cirrhosis; molecular pathogenesis; fibrosis and inflammation; epigenetics; hepatocellular carcinoma (HCC); viral hepatitis; molecular mechanism; hepatic nutrition; therapeutic targets; translational hepatology; MASLD; ALD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Crosstalk Between Metabolic Dysregulation and Neuropsychiatric Disorders: Novel Therapeutic Perspectives

edited by Aleksandra Szopa and Anna D. Serefko

submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut– brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 30 Apr 2026 | Viewed by 93 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by