Tumor Organoids in Translational Cancer Research: Mechanisms and Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 10
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Special Issue, “Tumor Organoids in Translational Cancer Research: Mechanisms and Applications”, of the International Journal of Molecular Sciences presents the amazing possibility of tumor organoid technology in discovering the molecular, genetic, and phenotypic layers of cancer. Tumor organoids—three-dimensional culture systems made from patient tissues—can mimic the cell type mix, structure, and communication of the original tumors very faithfully. The issue features organoid-based cancer modeling advancements, including their application in the study of tumor evolution, drug resistance mechanisms, and tumor-microenvironment interactions.
The combination of organoid platforms with multi-omics profiling not only provides the opportunity to explore tumor heterogeneity but also makes precision oncology approaches more accessible. These molecular methods allow for the thorough examination of genomic alterations, transcriptomic signatures, proteomic landscapes, and metabolic profiles within organoid systems, thereby providing unprecedented insights into cancer biology at the molecular level. In addition, organoid models enable researchers to investigate the dysregulation of signaling pathways and gene-environment interactions that contribute to tumor development and resistance to therapy. The articles in this issue not only strive to enhance scientific comprehension but also aim at the molecular oncology's field through the employment of cutting-edge organoid models.
Dr. Yong-Jun Kwon
Guest Editor
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Keywords
- tumor organoids
- tumor heterogeneity
- multi-omics profiling
- drug resistance
- tumor microenvironment
- patient-derived models
- organoid biobank
- high-throughput drug screening
- personalized therapy
- translational research
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