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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research and Application of Platelet-Rich Plasma
edited by
submission deadline 30 Jan 2026 | Viewed by 142 | Submission Open
Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine
(This special issue belongs to the Section Molecular Biology)
Advanced Therapy for Human Haemoglobinopathy
edited by Alex Felice and
submission deadline 30 Jan 2026 | Viewed by 142 | Submission Open
Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances of Osteomuscolar Conditions
edited by
submission deadline 30 Jan 2026 | Viewed by 141 | Submission Open
Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Rewriting Medicine: Stem Cells and Regeneration
edited by
submission deadline 30 Jan 2026 | Viewed by 138 | Submission Open
Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Brain Cancers: Second Edition submission deadline 30 Jan 2026 | 1 articles | Viewed by 136 | Submission Open
Keywords: brain tumors; malignant brain tumor; advanced cancer biology
(This special issue belongs to the Section Molecular Oncology)
Recent Research on Gut Microbiota in Health and Disease
edited by Li Cui
submission deadline 30 Jan 2026 | Viewed by 135 | Submission Open
Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut– brain axis; translational microbiome
(This special issue belongs to the Section Molecular Microbiology)
Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML
edited by
submission deadline 30 Jan 2026 | Viewed by 121 | Submission Open
Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML
(This special issue belongs to the Section Molecular Oncology)
Tumor Viruses: Infection, Carcinogenesis, and Treatment
edited by
submission deadline 30 Jan 2026 | Viewed by 119 | Submission Open
Keywords: tumor viruses; viral oncogenesis; EBV; HPV; KSHV; HBV; HCV; HTLV-1; and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies
(This special issue belongs to the Section Molecular Microbiology)
DNA Damage, Genome Stability and the Human Disease
edited by
submission deadline 30 Jan 2026 | Viewed by 117 | Submission Open
Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cardiovascular Diseases: From Molecular Diagnosis to Treatment
edited by
submission deadline 30 Jan 2026 | Viewed by 108 | Submission Open
Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Environmental Carcinogenesis
edited by Grażyna Gromadzka
submission deadline 30 Jan 2026 | Viewed by 84 | Submission Open
Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment
(This special issue belongs to the Section Molecular Toxicology)
Sarcomeric Proteins in Health and Disease: Progress and Prospects
edited by
submission deadline 30 Jan 2026 | Viewed by 84 | Submission Open
Keywords: sarcomeric proteins; muscle contraction; sarcomere
(This special issue belongs to the Section Molecular Biophysics)
Neural Signaling: The Perspective of Molecular Genetics
edited by
submission deadline 30 Jan 2026 | Viewed by 83 | Submission Open
Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development
edited by
submission deadline 30 Jan 2026 | Viewed by 73 | Submission Open
Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Roles of Epithelial and Endothelial Cells submission deadline 31 Jan 2026 | 9 articles | Viewed by 18616 | Submission Open
Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier
(This special issue belongs to the Section Biochemistry)
Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019
edited by
submission deadline 31 Jan 2026 | 6 articles | Viewed by 8176 | Submission Open
Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 7693 | Submission Open
Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma
(This special issue belongs to the Section Molecular Oncology)
Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition submission deadline 31 Jan 2026 | 5 articles | Viewed by 4460 | Submission Open
Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cytokines and Other Biomarkers of Health Status
edited by Anna Cywińska and
submission deadline 31 Jan 2026 | 5 articles | Viewed by 4373 | Submission Open
Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research into Chronic Heart Failure
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4188 | Submission Open
Keywords: heart failure; oxidative stress; cardiac remodeling; cardiomyopathy; proteomic; molecular science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3952 | Submission Open
Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis
(This special issue belongs to the Section Molecular Neurobiology)
Fish Nutrition, Biochemical Pathways, and Physiological Adaptations
edited by Paula Simó-Mirabet and Fernando Naya-Català
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3516 | Submission Open
Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture
(This special issue belongs to the Section Molecular Biology)
Antibody Engineering and Therapeutic Applications
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2981 | Submission Open
Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action
(This special issue belongs to the Section Molecular Pharmacology)
Oxidative and Redox Signalling in Neurological Diseases
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2436 | Submission Open
Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Plant–Microbe Interaction submission deadline 31 Jan 2026 | 1 articles | Viewed by 2419 | Submission Open
Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition
edited by Ilaria Marrocco and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2385 | Submission Open
Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery
(This special issue belongs to the Section Molecular Oncology)
Nutraceuticals and Healthy Aging: Molecular Mechanisms and Therapeutic Perspectives
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2236 | Submission Open
Keywords: molecular mechanisms of the action of nutraceuticals on cellular aging; nutraceuticals and neuroprotection; effects of nutraceuticals on skin aging; nutraceuticals in the prevention or management of age-related metabolic diseases; interaction between nutraceuticals and gut microbiota in aging; nutraceuticals in bone and joint health; role of nutraceuticals in menopausal management; impact of nutraceuticals on BPH and prostate health; multi-target approaches of nutraceuticals in healthy aging; innovative nutraceutical delivery and formulation strategies to increase bioavailability; clinical and preclinical studies of nutraceuticals in the elderly population
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Innovative Strategies and Molecular Insights Into Wound Healing
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1970 | Submission Open
Keywords: wound healing; tissue regeneration; hypertrophic scar; biomaterials; stem cell therapy; gene therapy; exosomes; burn rehabilitation; inflammation; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1872 | Submission Open
Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype
(This special issue belongs to the Section Molecular Immunology)
Neuropharmacological Innovations in Treating Neurodegenerative Diseases
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1697 | Submission Open
Keywords: neuropharmacology; neurodegenerative disorders; targeted drug delivery; blood– brain barrier permeability; synaptic modulation; neuroprotective agents; disease-modifying therapies; molecular mechanisms of neurodegeneration; innovative drug targets; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside
edited by Irina Ivanova Stoyanova
submission deadline 31 Jan 2026 | 3 articles | Viewed by 1683 | Submission Open
Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma
(This special issue belongs to the Section Molecular Neurobiology)
RNA-Based Regulation in Human Health and Disease submission deadline 31 Jan 2026 | 1 articles | Viewed by 1635 | Submission Open
Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery
(This special issue belongs to the Section Molecular Genetics and Genomics)
HIV Infection, Pathogenesis and Treatment
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1625 | Submission Open
Keywords: HIV Infection; HIV; host immune responses; pathogenesis
(This special issue belongs to the Section Molecular Microbiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Biology submission deadline 31 Jan 2026 | 2 articles | Viewed by 1582 | Submission Open
Keywords: next-generation sequencing (NGS); CRISPR-Cas9; liquid biopsy; molecular diagnostics; personalized medicine; genome-wide association studies (GWAS)
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Pancreatic Diseases
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1547 | Submission Open
Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Voltage-Gating and Modulation in Ion Channels
edited by Joao Carvalho de Souza
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1337 | Submission Open
Keywords: voltage-gated ion channels; voltage sensing; voltage sensor coupling; new modulators; ion channel modulation; cell excitability
(This special issue belongs to the Section Molecular Biophysics)
Abiotic Stress in Plants: Physiological and Molecular Responses
edited by Edyta Zdunek-Zastocka
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1307 | Submission Open
Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Radiation Oncology: Mechanisms, Immunotherapy and Innovation
edited by Jasna But-Hadžić
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1273 | Submission Open
Keywords: molecular radiation oncology; DNA damage response; immunoradiotherapy; radiosensitization; tumor– immune interactions; radiogenomics; predictive biomarkers; combination therapies; translational radiobiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Strategies Targeting Solid Tumors and the Tumor Microenvironment
edited by Emanuela Berrino and
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1241 | Submission Open
Keywords: cancer; tumor microenvironment; medicinal chemistry; drug design; structure– activity relationships; nanotechnologies; antibody– drug conjugates; non-coding RNAs; epigenetic
(This special issue belongs to the Section Molecular Oncology)
Cell Proliferation and Differentiation in Cancer submission deadline 31 Jan 2026 | 1 articles | Viewed by 1237 | Submission Open
Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion
(This special issue belongs to the Section Molecular Oncology)
Ion Channels as Therapeutic Target: Drug Design and Pharmacological Investigation (3rd Edition)
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1226 | Submission Open
Keywords: LGIC; voltage-gated ion channel; other ion channels; biological studies; molecular modeling; drug design; synthesis
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Molecular Target and Anti-Cancer Therapies
edited by Laura Denisa Dragu
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1200 | Submission Open
Keywords: cancer; conventional therapy; targeted therapy; immunotherapy; natural compounds; combinatorial therapy; molecular target; molecular mechanism; drug design; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Genetics and Genomics of Aquatic Crustaceans
edited by , Falin Zhou and Lingbo Ma
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1182 | Submission Open
Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms of Toxicity Induced by Engineered Nanomaterials submission deadline 31 Jan 2026 | 1 articles | Viewed by 1073 | Submission Open
Keywords: toxicity; occupational health; engineered nanomaterials; physical– chemical characteristics; toxicokinetic; toxicodynamic; in vivo; NAMs; NGRA (new-generation risk assessment)
(This special issue belongs to the Section Molecular Toxicology)
Advances in Basic and Translational Research in Colorectal Cancer
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1032 | Submission Open
Keywords: colorectal cancer; diagnostic and prognostic biomarkers; genetic and epigenetic alterations; MMR/MSI; cytokine profiling; inflammatory mediators; gut microbiota; tumor microenvironment; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Epilepsy: Exploring the Molecular Mechanisms and Potential Medications
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Plant Virus Infection, Resistance and Control
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: plant virus; host– pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Synthesis, Biosynthesis and Implications of Chalcones
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 853 | Submission Open
Keywords: chalcones; biosynthesis; biochemistry
(This special issue belongs to the Section Biochemistry)
The Interactions Between Nutrients and Adipose Tissue
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 841 | Submission Open
Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Functional Nanomaterials
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 796 | Submission Open
Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods
(This special issue belongs to the Section Molecular Nanoscience)
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