25th Anniversary of IJMS: Updates and Advances in Molecular Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 January 2026
Special Issue Editors
Interests: nerve injury and neuropathic pain; pain and aging; central adaptations to chronic pain; multiple sclerosis; neuroinflammation; neuro-immunologic communication; redox signaling; nitric oxide; endocannabinoids and other lipid signaling molecules; progranulin; autophagy
Special Issues, Collections and Topics in MDPI journals
Interests: autophagy; molecular biology; pathology; epidermal growth factor receptors family; cancer
Special Issues, Collections and Topics in MDPI journals
Interests: integrative physiology; oxygen; challenging environments; hyperbaric; hypobaric; hyperoxia; hypoxia; normobaric oxygen paradox
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The last two decades have marked a revolutionary period in molecular biology, with foundational discoveries rapidly translating into clinical applications that are fundamentally reshaping our approach to complex human diseases. This Special Issue aims to bring together a collection of high-impact research and review articles that highlight the leading edge of molecular biology as it applies to oncology, (auto)immune diseases, and infectious diseases. We invite the submission of manuscripts that detail the profound impact of molecular techniques on personalized oncology. This includes research on the expanding applications of next-generation sequencing (NGS), including single-cell "omics" and the clinical utility of liquid biopsies for early cancer detection, prognostic stratification, and the real-time monitoring of therapeutic resistance. Furthermore, we encourage contributions that explore the frontier of molecular therapeutics, such as the application of CRISPR-Cas9 gene editing, RNAi-based strategies, and other innovations in cellular engineering aimed at creating curative cancer treatments.
In parallel, our understanding of immune disorders is being redefined through molecular investigation. We are seeking contributions that highlight the use of genome-wide association studies (GWAS) and other omics technologies in identifying genetic susceptibilities and disease-specific pathways. Of particular interest is research focused on the discovery and validation of novel molecular biomarkers for more precise diagnostics and the development of targeted therapies. This includes work on the role of immunogenetics, such as HLA genotyping, in predicting disease risk and tailoring patient treatment. The field of infectious diseases has also been fundamentally altered by molecular diagnostics, which have become a cornerstone of modern epidemiology. This Special Issue will welcome papers on the development of advanced diagnostic platforms, from refined PCR-based methods to the emergence of highly specific CRISPR-based tools for pathogen detection. We also solicit research leveraging NGS for pathogen or microbiome genomics, which is critical for robust epidemiological surveillance, tracking antimicrobial resistance, and achieving a deeper understanding of host-pathogen interactions at the molecular level. By bringing these interconnected fields together, this Special Issue will serve as an essential resource for clinicians and researchers, providing a comprehensive overview of the current and future state of molecularly informed medicine.
Prof. Dr. Irmgard Tegeder
Dr. Antonio Ieni
Prof. Dr. Costantino Balestra
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Next-generation sequencing (NGS)
- CRISPR-Cas9
- Liquid biopsy
- Molecular diagnostics
- Personalized medicine
- Genome-wide association studies (GWAS)
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
