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Cytokines and Other Biomarkers of Health Status

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 566

Special Issue Editors


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Guest Editor
Department of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, Lwowska 1, 87-100 Toruń, Poland
Interests: veterinary medicine; cytokine; horse

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Guest Editor
Laboratory of Genetics, Department of Biomedical Sciences, Faculty of Physical Education, Józef Piłsudski University of Physical Education, 00-968 Warsaw, Poland
Interests: genes; nutritional; cytokine
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Special Issue Information

Dear Colleagues,

Cytokines initiate, regulate, promote and inhibit a wide variety of physiological and pathological processes in humans and animals. They act as a network which is also closely related to other molecules orchestrating to shape the biological processes involved in both health and disease. The measurements of particular biomarkers and the changes in their levels give a deeper insight into the onset of biological responses, including acute and chronic inflammation, autoimmunity, cancer, and organ failure, as well as adaptation to age-related changes and environmental conditions. Better understanding the cytokine balance not only extends our knowledge of physiology and the pathogenesis of diseases, including the early onset of pathologies, but gives an opportunity to consider the novel diagnostic and therapeutic strategies. 
This Special Issue focuses on cytokines as biomarkers of various physiological and pathological conditions as well as the interactions and balance of other biomarkers. We welcome original studies and reviews that advance and summarize the understanding of biomarkers orchestrating various biological processes as well as diagnostic trends. 

Prof. Dr. Anna Cywińska
Prof. Dr. Ewelina Maculewicz
Guest Editors

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Keywords

  • cytokine concentration
  • cytokine gene expression
  • cytokine receptors
  • biomarkers
  • pathogenesis
  • adaptation
  • homeostasis

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Published Papers (1 paper)

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Research

18 pages, 281 KB  
Article
Connections Between Gene Polymorphism and Fetlock and Hock Measurements in Polish Sport Horses
by Dorota Lewczuk, Maria Wypchło, Mateusz Hecold, Roma Buczkowska and Agnieszka Korwin-Kossakowska
Int. J. Mol. Sci. 2025, 26(19), 9645; https://doi.org/10.3390/ijms26199645 - 2 Oct 2025
Viewed by 358
Abstract
Finding the causative mutations for musculoskeletal system development and health status is of a higher priority for all sport horse breeders’ associations. Of the regulating proteins involved in animal ossification, 15 gene polymorphisms were chosen to be identified as connected with the nine [...] Read more.
Finding the causative mutations for musculoskeletal system development and health status is of a higher priority for all sport horse breeders’ associations. Of the regulating proteins involved in animal ossification, 15 gene polymorphisms were chosen to be identified as connected with the nine fetlock and 14 hock bone structures measurements of 198 horses. All measurements were taken using X-rays of the limbs, which were available at the beginning and end of the horse training. The analysis of variance (GLM, SAS program) was performed taking into account identified training and horse-connected characteristics, and gene polymorphism. The larger size of the bone structure was achieved in the fetlock for the heterozygotes of COL9A2, AOAH1, BMPER, HYAL3, and ELMO1. The heterozygotes were superior to homozygotes in the hock for the following genes: COL9A2, HYAL3, ANLN, and HYAL1. The lower homozygote values were obtained for GG in CPVL in fetlock measurements, TT for HYAL3 in fetlock, TT for ANLN in fetlock, CC for FRZB in the hock, TT for MATN in the hock, and TT for COL5A2 in the hock than their opposite homozygote and heterozygote variants. COL9A2 and HYAL3 are expressed in the same way for most of the bone structures in both joints. Full article
(This article belongs to the Special Issue Cytokines and Other Biomarkers of Health Status)
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