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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Biomarkers and New Therapeutic Options in Neoplastic Diseases

edited by

Maurizio Martini

submission deadline 30 Dec 2025 | Viewed by 138 | Submission Open

Keywords: biomarkers; neoplastic diseases; molecular targets; targeted therapy; precision oncology; signaling pathways; cancer diagnostics; therapeutic options; drug resistance; molecular profiling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition

edited by Antonella Ciabattoni and Fabiana Gregucci

submission deadline 30 Dec 2025 | Viewed by 117 | Submission Open

Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

(This special issue belongs to the Section Molecular Oncology)

The Role of Diet in Lipid and Lipoprotein Metabolism

edited by

Kyung-Hyun Cho

submission deadline 30 Dec 2025 | Viewed by 111 | Submission Open

Keywords: dyslipidemia; hypertension; diabetes; dementia

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage

edited by Antonio Arnaiz-Villena

submission deadline 30 Dec 2025 | Viewed by 101 | Submission Open

Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G; E; F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal MHC; Veterinary

(This special issue belongs to the Section Molecular Immunology)

Research on the Key Role of Ubiquitination in Signaling and Cancer

edited by

Bo Zhao

submission deadline 30 Dec 2025 | Viewed by 97 | Submission Open

Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development

(This special issue belongs to the Section Molecular Oncology)

Effects of Bioactive Compounds in Oxidative Stress and Inflammation

edited by

Paul-Mihai Boarescu

and

Raluca Maria Pop

submission deadline 31 Dec 2025 | 9 articles | Viewed by 32641 | Submission Open

Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Schizophrenia: From Molecular Mechanism to Therapy

edited by

Yael Abreu-Villaça

submission deadline 31 Dec 2025 | 7 articles | Viewed by 25763 | Submission Open

Keywords: schizophrenia; neurodevelopmental disorders; therapeutic approaches; drug of abuse; mental disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Lipids in Health and Diseases

edited by

Yutang Wang

submission deadline 31 Dec 2025 | 8 articles | Viewed by 19561 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Research Progress of Metabolomics in Health and Disease

edited by

Maria Assunta Acquavia

submission deadline 31 Dec 2025 | 10 articles | Viewed by 19177 | Submission Open

Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques

(This special issue belongs to the Section Molecular Biology)

Biological Research on Plant Bioactive Compounds

edited by

Adriana Trifan

and

Simon Vlad Luca

submission deadline 31 Dec 2025 | 9 articles | Viewed by 18760 | Submission Open

Keywords: plant bioactive compounds; extraction and analysis of plant bioactive compounds; bioactivity and pharmacokinetics of plant compounds; natural products and modern diseases; plant bioactive compounds and by-products; discovery and development of natural plant drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Phyto-Functional Nanomaterials: Synthesis, Characterization and Application

edited by

Maria G. P. M. S. Neves

Carla Isabel Madeira dos Santos

and

Nuno M. M. Moura

submission deadline 31 Dec 2025 | 9 articles | Viewed by 16776 | Submission Open

Keywords: phyto-functional nanomaterials; green synthesis; hydrogen generation; pollutant degradation/removal; fine chemistry; photoinactivation; cancer; microorganisms

(This special issue belongs to the Section Molecular Nanoscience)

The Impact of Natural Bioactive Compounds on Human Health and Disease

edited by

Yeong-geun Lee

submission deadline 31 Dec 2025 | 6 articles | Viewed by 16134 | Submission Open

Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug

(This special issue belongs to the Section Molecular Pharmacology)

Natural Products in Drug Discovery and Development

edited by Tian-Le Gao

submission deadline 31 Dec 2025 | 11 articles | Viewed by 16081 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Editorial Board Members’ Collection Series: Cancer Metastasis

edited by

Carlos Cabañas

and

Sung-Hoon Kim

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15959 | Submission Open

Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Updates and Advances in Molecular Oncology

edited by

Peter J. K. Kuppen

submission deadline 31 Dec 2025 | 13 articles | Viewed by 13912 | Submission Open

Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology

edited by

Kiminobu Sugaya

submission deadline 31 Dec 2025 | 9 articles | Viewed by 12893 | Submission Open

Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics; proteomics; transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism

edited by

José L. Quiles

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12843 | Submission Open

Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10770 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products

edited by

Huayu Sun

submission deadline 31 Dec 2025 | 8 articles | Viewed by 10465 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Macromolecules

edited by

Haiyang Gao

Salah-Eddine Stiriba

and

Zhongzhou Chen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8092 | Submission Open

Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship

(This special issue belongs to the Section Macromolecules)

Coordination Complexes: From Molecular Design to Functional Applications

edited by

Sanaa Musa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8067 | Submission Open

Keywords: coordination complexes; organometallic complexes; functional materials; metal– ligand interactions; homogenous catalysis; sensing; magnetic materials; ligand tunability

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Dietary Supplements: A Delicate Balance Between Benefit and Harm

edited by

Carmen Cantisani

submission deadline 31 Dec 2025 | 1 articles | Viewed by 7422 | Submission Open

Keywords: dietary supplements; antioxidants; skin; ageing; wellness

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7051 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Metabolic Diseases

edited by

Dariusz Chlubek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6614 | Submission Open

Keywords: metabolic diseases; enzymes related to metabolic disorders; inborn errors of metabolism; inherited single-gene anomalies; molecular diagnostics in metabolic disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines

edited by

Juliann G. Kiang

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5982 | Submission Open

Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain

(This special issue belongs to the Section Molecular Immunology)

25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics

edited by

Francesco Sessa

Lasse Lindahl

and

Apostolos Zaravinos

submission deadline 31 Dec 2025 | 5 articles | Viewed by 5936 | Submission Open

Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers

edited by

Alessandro Mannucci

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5657 | Submission Open

Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 31 Dec 2025 | 7 articles | Viewed by 5563 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5168 | Submission Open

Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Targeted Delivery of Nucleic Acids

edited by Yong-Serk Park

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5158 | Submission Open

Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Advances in the Relationship Between Diet and Insulin Resistance

edited by

Domenico Sergi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4707 | Submission Open

Keywords: insulin resistance; lipotoxicity; lipid metabolism; type 2 diabetes mellitus; dietary lipids; lipidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3941 | Submission Open

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

Ion and Molecule Transport in Membrane Systems, 6th Edition

edited by

Victor V. Nikonenko

and

Dmitrii Butylskii

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3829 | Submission Open

Keywords: ion and molecular transport; physical chemistry; chemical physics; transport mechanisms; living systems; biological and artificial membranes; biomimetic structure; structure– property relationships; thermodynamics; irreversible thermodynamics; equilibriums; kinetics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3660 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Biological Activities of Curcumin and Its Analogues

edited by Francis Johnson

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3656 | Submission Open

Keywords: curcumin; analogues; natural compounds; inflammation; tissue reconstruction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism Involved in Cancer Metastasis

edited by

Mohamed Jemaà

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3490 | Submission Open

Keywords: cell motility; cell migration; spheroid; metastasis; extracellular matrix; cell architecture; lamellipodia; epithelial-mesenchymal transition EMT; videomicroscopy; confocal microscopy; animal model

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3148 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nanobiomaterials and Beyond: Innovations in Drug Delivery, Diagnostics, and Therapeutics

edited by

Alexandru Mihai Grumezescu

and

Adelina-Gabriela Niculescu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3123 | Submission Open

Keywords: nanobiomaterials; drug delivery systems; targeted drug delivery; controlled drug release; stimulus-responsive nanomaterials; biocompatibility; biodegradability; functionalized nanocarriers; theranostics; nanocarriers for cancer therapy; tumor-targeted drug delivery; organ-specific delivery systems; pH-responsive materials; temperature-sensitive nanobiomaterials; light-activated drug delivery; enzyme-responsive systems; multimodal nanomaterials; translational nanomedicine; computational modeling in nanobiomaterials; preclinical studies of nanomaterials

(This special issue belongs to the Section Materials Science)

Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine

edited by

Gangho Lee

submission deadline 31 Dec 2025 | 5 articles | Viewed by 3084 | Submission Open

Keywords: nanoparticle; nanomaterial; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agent; therapeutic agent

(This special issue belongs to the Section Molecular Nanoscience)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2758 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines; adipokines; chemokines; epigenetics; microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy

edited by

Furong Tian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2648 | Submission Open

Keywords: neurodegenerative diseases; brain cancer; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

25th Anniversary of IJMS: Updates and Advances in Molecular Informatics

edited by

M. Natália D.S. Cordeiro

and

Giulio Vistoli

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2550 | Submission Open

Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering

(This special issue belongs to the Section Molecular Informatics)

25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology

edited by

Roberto Scatena

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2307 | Submission Open

Keywords: precision medicine; pharmacogenomics; targeted protein degradation (TPD); molecular pharmacology; RNA Therapeutics; novel drug modalities; proteomics; transcriptomics; personalized drug therapy

(This special issue belongs to the Section Molecular Pharmacology)

Plant Genome Evolution and Environmental Adaptation

edited by

Zhonghu Li

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2053 | Submission Open

Keywords: plant phylogeny; genome evolution; molecular evolution of cytoplasmic genomes; species divergence

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management

edited by

Jingli Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1963 | Submission Open

Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Focus on Plant Biotechnology and Molecular Breeding

edited by

Magdalena Wróbel-Kwiatkowska

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1906 | Submission Open

Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into RNA Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1879 | Submission Open

Keywords: RNA splicing; RNA modification; RNA processing; translation; RNA transport

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Ovarian Cancer Metastasis and Chemotherapy Resistance

edited by

Carmela Ricciardelli

and

Noor A. Lokman

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1845 | Submission Open

Keywords: ovarian cancer; metastasis; biomarkers; chemotherapy resistance; tumor microenvironment; peritoneal– cancer cell interactions; proteomics; novel therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions

edited by

Sylwia Smolińska

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1769 | Submission Open

Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways

(This special issue belongs to the Section Molecular Immunology)

Targeted Pharmacological Modulation of Cellular Pathology and Drug Discovery: A Translational Approach to Bridge Laboratory Discoveries with Clinical Practice

edited by Saurav Mallik

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1740 | Submission Open

Keywords: targeted pharmacotherapy; cellular pathology; translational medicine; drug mechanism of action; signal transduction modulation; precision medicine; apoptosis and autophagy; biomarker-guided therapy; pathophysiology-driven drug design; clinical applications of molecular targets; molecular docking

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 101-150 on page 3 of 65.

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