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The Biological Activities of Curcumin and Its Analogues

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 96

Special Issue Editor


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Guest Editor
Department of Chemistry, Stony Brook University, Stony Brook, NY 11790-3400, USA
Interests: periodontitis

Special Issue Information

Dear Colleagues,

Our research mainly focused on an analogue of curcumin, namely CMC 2.24. This substance demonstrates all of the properties of its parent, but extends much beyond that, not only in suppressing inflammation but in inverting macrophage activity from the M1 to the M2 state, thereby reversing their more usual activity of tissue debridement to tissue reconstruction. There is evidence that even replacement of eroded tissue may occur. A singular feature of CMC2.24 is its enhanced solubility in the bloodstream vs. curcumin itself, which is extremely insoluble and virtually useless as an oral medication.

The publication of this Special Issue offers authors a chance to engage with a wide audience and gain high visibility within the biological activities of curcumin and its analogues. Original research and review articles which provide insights are welcome.

Prof. Dr. Francis Johnson
Guest Editor

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Keywords

  • curcumin
  • analogues
  • natural compounds
  • inflammation
  • tissue reconstruction

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Published Papers (1 paper)

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Review

26 pages, 842 KB  
Review
The Effect of Curcumin on Postmenopausal Symptoms: A Systematic Review Based on Randomized Controlled Trials
by Buket Akyakar, İrem Nur Şahin, Duygu Ağagündüz, Dávid Szép and Ferenc Budán
Int. J. Mol. Sci. 2025, 26(17), 8260; https://doi.org/10.3390/ijms26178260 - 26 Aug 2025
Abstract
Menopause is a natural and inevitable part of life for women, leading to many physical and psychological changes accompanied by declining estrogen levels. This systematic review aimed to evaluate the effect of curcumin, due to its antioxidant and anti-inflammatory properties, on postmenopausal outcomes [...] Read more.
Menopause is a natural and inevitable part of life for women, leading to many physical and psychological changes accompanied by declining estrogen levels. This systematic review aimed to evaluate the effect of curcumin, due to its antioxidant and anti-inflammatory properties, on postmenopausal outcomes in women. This comprehensive analysis of RCTs (randomized controlled trials) published in the last decade was selected through a search of PubMed, Wiley, Scopus, and Web of Science (PROSPERO Identifier: CRD42024549735). Study selection and data extraction were performed using exclusion and inclusion criteria according to the PICOS framework (P: Population, I: Intervention, C: Comparison, O: Outcomes, S: Study designs). Of the twelve studies that met the criteria, 11 had a low-risk bias, but reports were conflicting on serum estradiol levels, bone density markers, and vasomotor symptoms; no significant effects on physical, psychological, or sexual functions were observed. For cardiometabolic biomarkers, short-term curcumin intake showed no significant effects, while long-term interventions using bioavailable forms of curcumin showed improvements in serum fasting glucose, fasting insulin, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance), and lipid parameters. There are a limited number of studies examining the effect of curcumin intake on menopause-related outcomes. While overdose has been observed in some studies attempting to restore estradiol levels, no significant effects have been observed. However, curcumin intake impacts postmenopausal symptoms (e.g., improving symptoms of osteoporosis) through its antioxidant and anti-inflammatory effects. Different forms and doses, combinations, and durations of interventions may influence outcomes. Better-designed studies are needed to understand the potential effects of curcumin intake during menopause. Full article
(This article belongs to the Special Issue The Biological Activities of Curcumin and Its Analogues)
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