New Horizons for Investigating Respiratory Diseases: Inflammation and Repair

Dear Colleagues,

Respiratory inflammatory diseases are the leading cause of severe illness globally. Despite recent advances in therapeutic strategies, for many patients, these diseases are progressive with associated enhanced morbidity and mortality. In fact, the number of deaths from chronic inflammatory lung diseases has increased by 20% over recent years. The pathogenesis of respiratory inflammatory diseases involves multipart interactions between pro-inflammatory stimuli and a variety of cell types including neutrophils, macrophages, and lymphocytes, causing the destruction of lung parenchyma and airway remodeling.

Hence, there is an urgent requirement to develop innovative approaches to diagnose and treat pulmonary inflammatory diseases. To this end, numerous novel treatment strategies and diagnostic methods are required. Moreover, understanding the key regulators of inflammation and repair in pulmonary diseases remains a major impediment.

Lead by Dr. Ronan MacLoughlin and assisted by Dr. Mohammad Doroudian and Dr. Mohsen Moghoofei, this forthcoming Special Issue aims to provide an overview of the current understanding of respiratory diseases and their molecular mechanisms. We invite reviews and original research describing the recent advances in novel treatment strategies, newly identified/better understood molecular mechanisms as well as novel therapeutics and treatments for lung diseases. Of key value from this Special Issue shall be the translational considerations, and how do we move from the bench to the bedside.

Dr. Ronan MacLoughlin
Guest Editor

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