Ubiquitin-Conjugating or Deubiquitinating Enzymes in Signal Transduction Pathways

Dear Colleagues,

For cellular homeostasis, the regulation of selective proteolysis is largely mediated by the posttranslational modification with the coordinated addition and removal of ubiquitin by the ubiquitin–proteasome system. Both ubiquitin-conjugating and deubiquitinating enzymes regulate the stability or function of proteins, allowing regulation of protein turnover through diverse signaling pathways. Dysregulation of these enzymes is increasingly being identified as a causative in various human diseases, such as cancers, metabolic diseases, neurodegenerative disorders, and so on. Therefore, a better understanding of the molecular mechanisms in signal transduction pathways will provide new insights into the development of more specific therapeutic approaches.

This Special Issue of the International Journal of Molecular Sciences will focus on the role of ubiquitin-conjugating and deubiquitinating enzymes including new insights into diverse signal transduction pathways, and articles submitted can either be original research works regarding these enzymes or full reviews; however, we kindly encourage authors to provide short and highly focused reviews on specific and hot topics related to human diseases.

Prof. Dr. Kwang-Hyun Baek
Guest Editor

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