Pluripotent Stem Cells and Organoids on Disease Modeling and Therapeutic Potentials

Dear Colleagues, 

Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential to maintain long-term self-renewing and mimic embryonic developing. In the phase of cells or organoids developed from PSCs, research models for inherited and acquired diseases and drug screening, even preclinical applications can be developed. With the discovery and application of the CRISPR/Cas9, in-depth investigation of physiological and pathological mechanism can be implemented, including but not limited to cell fate tracing and visualization, functional maturation, mutations exploration, gene correction and etiology rescue.

Much work remains to be done involving PSCs/iPSC-derived organoids, the reproducibility, scalability and long-term safety of differentiation and cellular functions, gene editing strategies and its applications in transplantation strategy, immune rejection, disease modeling, drug screening, etc.  We especially welcome the studies on induction of multi-cellular tissue-like structure or organoids from PSCs with novel technologies, and call for elucidation on their specific developmental roadmap in molecular level.

Thus, this Special Issue mainly calls for paper about advances and progresses of pluripotent stem cell/organoid-based researches in basic which aim to solve or improve the above problems. We invite the authors to submit their original and review articles on these topics.

Dr. Yun-Wen Zheng
Guest Editor

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