Sarcomeric Proteins in Health and Disease 2.0

Dear colleagues,

This Special Issue is the continuation of our previous Special Issue “Sarcomeric Proteins in Health and Disease”.

Many inherited diseases in skeletal and cardiac muscle have their origin in mutations in sarcomeric proteins. Developing rationale therapeutic strategies will require a detailed understanding of the normal structure and function of the proteins that comprise the sarcomere, as well as how these structures and functions are altered in disease.

The aim of the present Special Issue is to bring together reviews and original papers on the structure and function of specific components of the sarcomere as they relate to overall contractile function and its regulation in normal and diseased muscle tissue. Historically, the focus in molecular biophysical studies of muscle contraction has been on actin–myosin interaction.

This issue is intended to be an opportunity to explore other aspects of sarcomere structure and function. These could include topics such as:(1) the elastic properties of sarcomeric proteins and their role in regulation, (2) structural dynamics of the Z-lines and M-lines, (3) sarcomeric structural proteins and cell signaling pathways, and (4) regulation of turnover of sarcomeric proteins. This list is not intended to be exclusive. Any of these topics could include investigation and discussion of mutations and post-translational modification alter protein structure and either normal or pathological function.

Prof. Dr. Thomas C. Irving
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.