Advanced Research on Reproductive System Disease 2022

Dear Colleagues, 

Reproductive related diseases include a broad range of disorders, which incidence is increased in recent decades in both sexes, because of increasing risk factors, as obesity, sexually transmitted infections, environmental pollution and so on. A growing literature focused on the molecular mechanisms underlined to the reproductive system disorders, and different approaches have been developed to identify new early biomarkers disease, as well as news promising therapeutic targets. In this scenario, a highly promising tool is represented by the“-omic” technology. Recently it has been demonstrated that male and female gonadal cancers can be distinct not only in terms of histology but also in genomics, epigenomics and transcriptomics. Moreover, recent studies shown that epigenetic changes (as those environmental pollution-induced) are an important component of gametogenesis and related reproductive system diseases, including cancers. This innovative approach is crucial to developing new drugs to overcome the chemoresistance. In addition, understanding the role of post-transcriptional gene regulation in reproduction will help to clarify the causes of reproductive failure, providing methods and targets for the treatment of infertility, which represents well known consequence of congenital and aquired reproductive system disorders. Finally, in recent years the researchers have conducted in vivo and in vivo studies to investigate the molecular mechanism by which some natural products may be applied as new potential adiuvant therapeutic tool.

This Special Issue of the International Journal of Molecular Sciences focuses on the Reproductive System Disease research field and welcomes both original research articles and review papers that deal with the molecular mechanisms underlying the gonadal and sexual dysfunction and new advanced diagnostic and therapeutic approaches in the treatment of the above-reported disorders and of infertility.

Dr. Anna Perri
Guest Editor

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