Natural Anti-Inflammatory Agents
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 235138
Special Issue Editors
Interests: metabolite profiling of natural matrices; natural agents for inflammation; neurodegenerative disorders
Special Issues, Collections and Topics in MDPI journals
Interests: narural products; primary and secondary metabolites; bioactivity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is the organism’s natural response to stimuli that are perceived as harmful, from germs, toxins, environmental pollutants, to injury and stress, among others. This complex process involves immune, vascular and cellular biochemical reactions. At a damaged site, the process starts with the migration of immune cells from blood vessels and release of mediators, followed by recruitment of inflammatory cells and release of various oxidative agents and pro-inflammatory cytokines, arachidonic acid playing a pivotal role. Normal inflammation is self-limiting, but aberrant resolution and prolonged inflammation lead to chronic disorders, as excessive oxidants and inflammatory mediators have deleterious effects, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs, finally leading to systemic disorders. The search of new anti-inflammatory drugs has been a current preoccupation, due to the need of effective drugs, with less adverse reactions than those used nowadays. Concerning this issue, there has been increasing awareness of the potential interest in natural products. This Special Issue is devoted to the exploitation of natural matrices as sources of new anti-inflammatory molecules and their mechanism of action.
Prof. Dr. Paula B. Andrade
Prof. Dr. Patrícia Valentão
Guest Editors
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Keywords
- anti-inflammatory
- arachidonic acid
- cytokines
- eicosanoids
- gene expression
- inflammatory cells
- inflammatory enzymes
- natural products
- transcription factors
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