Liver-Gut Axis 3.0

Dear Colleagues,

Gut-derived nutrients and other signals are delivered to the liver via the portal circulation. As the largest immune organ, the liver hosts the entire spectrum of immune-cell repertoire. It has a remarkable capacity to recruit and activate immune cells in response to gut-derived metabolic or pathogen-derived signals. The crosstalk between the gut and the liver is increasingly recognized, strengthened by the parallel rise in liver diseases and gastrointestinal and immune disorders. The gut–liver axis is widely implicated in the pathogenesis of liver disease, including alcoholic liver disease, nonalcoholic fatty liver disease, primary biliary cholangitis, cirrhosis, hepatocellular carcinoma, and acute-on-chronic liver failure. The risk of damage to the liver increases when the intestinal barrier is damaged (“leaky gut”). Intestinal dysbiosis plays an important role in the development of chronic liver disease. The gut–liver axis has evolved from basic research to therapeutic strategies to improve the prognosis of chronic liver diseases. Further research on the gut–liver axis has led to new insights into the pathogenesis of liver disease and therapeutic strategies.

This Special Issue will be dedicated to the “Liver–Gut Axis”; it welcomes submissions, including original papers and reviews, on these widely discussed topics.

Dr. Takemi Akahane
Guest Editor

Manuscript Submission Information

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