Physiology of Red Cell Lineage: From Erythroblast Progenitors to Mature Red Blood Cell

Dear Colleagues,

Red blood cells (RBC) are the most abundant human cells, playing crucial physiological functions as O₂ and CO₂ transport and exchange and pH homeostasis. Bone marrow produces 2.10⁶ reticulocytes/sec, which will be released to the circulation and become mature RBC, having an average lifespan of 120 days before being cleared. Dysfunctions on the red cell production, red cell function or red cell elimination have deep consequences to health, and are responsible for several types of anemia, an emergent public health challenge.

This special issue aims to include different topics of the research on non-malignant hematology, including both basic and applied research investigating the mechanisms involved in physiology of erythroid differentiation as well as mature and senescent red blood cells.Unraveling these mechanisms will contribute to better understanding the pathophysiology of non-malignant hematological disease.

Research areas may include (but are not limited to) the following: erythrocyte function, erythropoiesis, organelle clearance, non-malignant hematological disease, and appropriate models and experimental approaches to study red blood cells and their production. Both original research articles and reviews on these topics are welcome.

Prof. Dr. Mariano Ostuni
Dr. Sarah Ducamp
Guest Editors

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