Mechanisms of Inflammation in Degenerative Cardiovascular Conditions 2.0

Dear Colleagues,

The burden of cardiovascular disease in Western societies keeps growing and continues to be the main cause of death. Research in the field for the investigation of new molecular mechanisms triggers the development of modern therapeutics. In the last few decades, multiple lines of evidence have suggested that inflammation is a key player in the development of cardiovascular diseases, accompanying this condition along its continuum. Indeed, inflamation coexists with many of the cardiovascular risk factors (smoke, obesity, dyslipidemia, hypertension, aging). Additionally, chronic inflammatory diseases, such as rheumatoid arthritis, also present increased cartdiovascular risk. The very mechanisms of target organ damage include inflammatory responses and inflamation cell infiltration. Moreover, targeting mechanisms of inflamation, such as pro-inflammatory cytokines (IL1β, TNFα), effectively affect the clinical outcomes of heart disease, supporting the entangled role of inflamation in cardiovascular events. In this context, the transcription factor NF-kB is emerging as a potential therapeutic target since it regulates the expression of inflammatory cytokines, but it is also associated with the development of heart diseases. Drug-dependent cardiotoxicity is also included in this field since Doxorubicin increases proinflammatory cytokines levels (TNF-α and IL-6) with a concomitant reduction of anti-inflammatory ones (IL-10) that could be responsible for the later onset of heart remodeling that leads to doxorubicin-dependent cardiomyopathy.

This Special Issue is a call for publication for all those researchers who have paved the way with their findings, but also an opportunity for cross-fertilization of the scenario by engaging scientists and clinicians to confront their ideas and their views, for the progression of the field. Authors are welcome to contribute original research articles, current review articles, and commentaries.

Prof. Dr. Guido Iaccarino
Dr. Daniela Sorriento
Dr. Jessica Gambardella
Guest Editors

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