FGF/FGFR Signaling Pathway in Development and Human Diseases

Dear Colleagues,

Due to their pleiotropic nature, FGFs and FGFRs play important roles in different physiological and pathological settings, and contribute to cancer progression not only by triggering a pro-angiogenic response but also by acting directly on tumor cells via paracrine and autocrine loops of stimulation. Recently, new roles have been attributed to the FGF/FGFR system in the complex cross-talk existing among different cell populations that are present in the tumor microenvironment. Moreover, FGF/FGFR signaling has been associated with other cancer hallmarks such as stemness, invasiveness, metabolic rewiring, and resistance to therapies.

Even though the characterization of the biological function of the FGF/FGFR system in cancer is proceeding, its diagnostic and therapeutic exploitation is ongoing in preclinical and clinical studies with some promising and other contradictory results.

In an attempt to add new hints and make a “state of the art” point, this Special Issue “FGF/FGFR Signaling Pathway in Development and Human Diseases” will cover a selection of recent research topics and current review articles in the field of FGF/FGFR biology applied to development and diseases research.

Prof. Dr. Roberto Ronca
Guest Editor

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