Advanced Research of Skin Inflammation and Related Diseases

Dear Colleagues,

Skin inflammation has many possible causes, including infections, allergies, and autoimmune diseases. During inflammation, the skin undergoes substantial changes: immune cells infiltrate the dermis and epidermis; keratinocytes, fibroblasts, and immune cells release a large amount of pro-inflammatory cytokines; and fibroblasts and myofibroblasts synthetize and deposit excessive components of the extracellular matrix, leading to fibrosis or scarring. In the last decades, numerous signalling proteins and microRNAs have been associated with chronic inflammatory conditions. Future studies should provide a systematic picture of the molecular mechanisms underlying skin inflammation; in particular, the evaluation of crosstalk between different cell types in the epidermis, dermis, and subcutaneous layers during inflammation should be performed.

In this Special Issue for IJMS, we will focus on molecular studies in biology and medicine as a promising approach to identify new therapeutic targets, as well as novel biomarkers with diagnostic significance in skin pathologies. In vitro data, human studies, and clinical observations in all fields of basic immune and skin inflammation research are welcome.

Dr. Filomena Napolitano
Dr. Valentina Giudice
Guest Editors

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