ERG Factor and Its Multiple Functions: New Insights

Dear Colleagues,

Among the 28 mammalian ETS (for E-26 transformation specific) transcription factors, the transcription factor ERG has emerged in the recent years as essential regulator of differentiation and maintenance of the endothelial lineage, and, therefore, for the development and maintenance of healthy vasculature. In addition, it also shows the role of promoter of oncogenesis, when ectopically expressed. Such multiple ERG actions are related to its binding to several ERG-dependent gene targets and pathways in the endothelium, including VEGF, Notch, Wnt/β-catenin signaling pathways. Recently, other physiological and pathological non-vasculature roles of ERG have been identified. For example, ERG is required for the physiological functions of primitive and adult hematopoiesis, as well as for bone and cartilage development, but also in pathogenesis of multiple cancers with ectopic expression (as above mentioned).

Although substantial progresses in understanding the functions of ERG have been made, much remains to be discovered. Thus, in this Special Issue, we widely recruit original articles that describe new discoveries on ERG factor in any relevant topics, such as physiological functions, regulation of new gene targets and signaling pathways, activation or inhibition of crucial human tissue mechanisms, as well as its roles in human diseases, such as multiple cancers. The identification of binding partners regulating ERG activity, the regulation of ERG function by post-translational modifications and by upstream signals, might provide insight into novel approaches to promote vascular health, as well as possible therapeutic options to selectively target the oncogenic function of ERG in cancer or other human pathologies. We also welcome review articles and commentaries.

Prof. Dr. Carmela Rita Balistreri
Dr. Beatrice Belmonte
Dr. Valeria Cancila
Guest Editors

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